Results 21 to 30 of about 14,471 (229)

Identification of Mre11 as a Target for Heat Radiosensitization [PDF]

, 2011
Thermal radiosensitization is believed to be mediated by an inhibition of double-strand break (DSB) repair, but the exact mechanism of radiosensitization remains to be elucidated. Previously, we demonstrated that proteins of the Mre11/Rad50/Nbs1 complex (
Batuello, Christopher N., Kim, Kyung Keun, John J. Turchi, Christopher N. Batuello, Kyung Keun Kim, Turchi, John J., Jennifer T. Lopez, Joseph R. Dynlacht, Lopez, Jennifer T., Dynlacht, Joseph R.   +9 more
core   +1 more source

Radiosensitization & Hyperthermia as Cancer Therapy [PDF]

, 2017
Kshitij Kolhatkar, Prabir Patra, and Alicia Petryk's poster on the use of radiosensitization and hyperthermia in the treatment of ...
Kolhatkar, Kshitij, Patra, Prabir, Petryk, Alicia   +2 more
core   +1 more source

Translation Initiation Machinery as a Tumor Selective Target for Radiosensitization

, 2021
Towards improving the efficacy of radiotherapy, one approach is to target the molecules and processes mediating cellular radioresponse. Along these lines, translational control of gene expression has been established as a fundamental component of ...
Evan D. Wilson, Stacey L. Lehman, Kevin Camphausen, Philip J. Tofilon   +3 more
core   +1 more source

Advances in the Application of Living Cells in Tumor Radiosensitization

BIO Integration
Radiation therapy (RT) has a critical role in cancer treatment, yet the efficacy is often limited by tumor resistance mechanisms, such as cellular DNA repair activation, heterogeneous cell cycle, hypoxia, and an immunosuppressive microenvironment ...
Haonan Xu, Renjie Feng, Hengrui Liu
doaj   +1 more source

Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond

Frontiers in Oncology, 2021
Radiotherapy is an essential component of multi-modality treatment of glioblastoma (GBM). However, treatment failure and recurrence are frequent and give rise to the dismal prognosis of this aggressive type of primary brain tumor.
Michael Orth, Valerie Albrecht, Karin Seidl, Linda Kinzel, Kristian Unger, Julia Hess, Lisa Kreutzer, Na Sun, Benjamin Stegen, Benjamin Stegen, Benjamin Stegen, Alexander Nieto, Jessica Maas, Nicolas Winssinger, Anna A. Friedl, Axel K. Walch, Claus Belka, Claus Belka, Claus Belka, Horst Zitzelsberger, Horst Zitzelsberger, Maximilian Niyazi, Kirsten Lauber, Kirsten Lauber, Kirsten Lauber   +24 more
doaj   +1 more source

Heat-induced Intranuclear Protein Aggregation and Thermal Radiosensitization

, 1995
In the current study, the hypothesis that thermal radiosensitization is (indirectly) caused by heat-induced denaturation and aggregation of nuclear proteins is further investigated.
Stege, G. J. J., Konings, A. W. T., Kampinga, H. H.; id_orcid   +2 more
core   +1 more source

Synergistic Radiosensitization by Gold Nanoparticles and the Histone Deacetylase Inhibitor SAHA in 2D and 3D Cancer Cell Cultures

Nanomaterials, 2020
Radiosensitizing agents are capable of augmenting the damage of ionizing radiation preferentially on cancer cells, thereby increasing the potency and the specificity of radiotherapy.
Nóra Igaz, Krisztina Szőke, Dávid Kovács, Andrea Buhala, Zoltán Varga, Péter Bélteky, Zsolt Rázga, László Tiszlavicz, Csaba Vizler, Katalin Hideghéty, Zoltán Kónya, Mónika Kiricsi   +11 more
doaj   +1 more source

Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451

Molecules, 2022
A tetrahydroisoquinoline (THIQ) core is able to mimic the A and B rings of 2-methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising anticancer properties primarily by disrupting microtubule dynamic instability parameters ...
Scott D. Hargrave, Anna M. Joubert, Barry V. L. Potter, Wolfgang Dohle, Sumari Marais, Anne E. Mercier   +5 more
doaj   +1 more source

Cell line-specific efficacy of thermoradiotherapy in human and canine cancer cells in vitro.

PLoS ONE, 2019
ObjectiveAims were to investigate sensitivity of various human and canine cancer cell lines to hyperthermia and the influence of particular treatment conditions, and to analyze the DNA-damage response and mode of cell death in cell line radiosensitized ...
Katarzyna J Nytko, Pauline Thumser-Henner, Mathias S Weyland, Stephan Scheidegger, Carla Rohrer Bley   +4 more
doaj   +1 more source

p53-Mediated Radiosensitization of ¹⁷⁷Lu-DOTATATE in Neuroblastoma Tumor Spheroids

Biomolecules, 2021
p53 is involved in DNA damage response and is an exciting target for radiosensitization in cancer. Targeted radionuclide therapy against somatostatin receptors with 177Lu-DOTATATE is currently being explored as a treatment for neuroblastoma.
Sara Lundsten, Hanna Berglund, Preeti Jha, Cecilia Krona, Mehran Hariri, Sven Nelander, David P. Lane, Marika Nestor   +7 more
doaj   +1 more source