Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect [PDF]
Nanomaterials, 2019 Gold nanoparticles (GNPs) have been shown to be effective contrast agents for imaging and emerge as powerful radiosensitizers, constituting a promising theranostic agent for cancer.
Sébastien Penninckx +2 more
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Radiosensitization by Gold Nanoparticles: Impact of the Size, Dose Rate, and Photon Energy
Nanomaterials, 2020 Gold nanoparticles (GNPs) emerged as promising antitumor radiosensitizers. However, the complex dependence of GNPs radiosensitization on the irradiation conditions remains unclear.
Kirill V. Morozov +11 more
doaj +2 more sources
Comparing and combining xevinapant with ATR and PARP inhibition for the radiosensitization of HPV-negative HNSCC cells [PDF]
Scientific ReportsRadiochemotherapy with the apoptosis stimulator xevinapant demonstrated superiority over radiochemotherapy in a randomized phase 2 trial in head and neck squamous cell carcinoma (HNSCC) but the subsequent phase 3 trial failed.
Julius Roehrle +9 more
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Gold Nanoparticle Radiosensitization for High-Dose-Rate Brachytherapy: Differential Efficacy of PEG- and RGD-Functionalized Gold Nanoparticles Across 2-Dimensional, 3-Dimensional, and in vivo Prostate Cancer Models [PDF]
International Journal of NanomedicineDaniel Cecchi,1 Nolan Jackson,1 Dmitri Karaman,2,3 Wayne Beckham,1 Chris D Johnstone,4 Samantha AM Lloyd,4,5 Devika Chithrani1,6,7 1Department of Physics and Astronomy, University of Victoria, Victoria, BC, Canada; 2Department of Mechanical Engineering ...
Cecchi D +6 more
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Frontiers in Bioengineering and Biotechnology, 2021 Radiotherapy is recommended as a modality for cancer treatment in clinic. However, cancerous cells were resistant to therapeutic irradiation due to its DNA repair.
Shengnan Yang +8 more
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Journal of International Medical Research, 2021 Objective Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has shown potential as a candidate radiosensitizer for many types of cancers.
Kan Wu +6 more
doaj +1 more source
Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells. [PDF]
PLoS ONE, 2016 Inhibition of mammalian target of rapamycin-complex 1 (mTORC1) induces activation of Akt. Because Akt activity mediates the repair of ionizing radiation-induced DNA double-strand breaks (DNA-DSBs) and consequently the radioresistance of solid tumors, we ...
Marina Holler +6 more
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Nature Communications, 2023 Gadolinium (Gd3+)-coordinated texaphyrin (Gd-Tex) is a promising radiosensitizer that entered clinical trials, but temporarily fails largely due to insufficient radiosensitization efficacy. Little attention has been given to using nanovesicles to improve
Xiaotu Ma +12 more
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Nanomaterials, 2022 Gold nanoparticles (AuNPs) can be used with megavolt (MV) X-rays to exert radiosensitization effects, as demonstrated in cell survival assays and mouse experiments.
Katsunori Yogo +8 more
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Evaluating the Radiosensitization Effect of Hydroxyapatite Nanoparticles on Human Breast Adenocarcinoma Cell Line and Fibroblast [PDF]
Iranian Journal of Medical Sciences, 2020 Background: Nanohydroxyapatite (nHAP) exhibit anti-proliferative effects on various cancer cells. However, to date, there are only a few studies on the radiosensitization effect of nHAP.
Mitra Soleimani +3 more
doaj +1 more source