Results 71 to 80 of about 10,413 (156)

Losartan Enhances Radiosensitivity by Reversing Immunosuppressive Tumor Microenvironment Induced by Radiotherapy in TNBC

Cancer Science, EarlyView.
Our study demonstrates that the angiotensin receptor blocker losartan enhances the efficacy of radiotherapy in triple‐negative breast cancer by reversing the immunosuppressive tumor microenvironment. Losartan reprograms tumor‐associated macrophages, inhibits myeloid‐derived suppressor cell function, and boosts CD8+ T‐cell activity.
Xu Wang, Cuiwei Liu, Zihan Xia, Ting Hu, Yuting Li, Dan Han, Yunjie Song, Yuxi Ma, Yanxia Zhao   +8 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Synergistic Effects of IMP‐1700, Ciprofloxacin, and X‐Ray Radiation in Bacteria and Mammalian Cell Lines: Implications for Use in Antimicrobial‐Resistant Bacteria

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
IMP‐1700 enhances the cytotoxic effect on bacteria in combination with either ciprofloxacin (CPX) or X‐ray. In noncancerous and tumor cells, combination treatments markedly reduce viability with radiosensitizing effects. Further studies are needed to clarify the mechanism underlying IMP‐1700s effects on mammalian cells. Created in BioRender. Kjaer, A. (
Ida Vang Andersen, Ane Beth Sloth, Emilie Caroline Skuladottir Bøgestad, Christian Bernard Matthijs Poulie, Anne Skovsbo Clausen, Umberto Maria Battisti, Matthias M. Herth, Andreas Kjaer   +7 more
wiley   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

Gadolinium-based nanoparticles for theranostic MRI-radiosensitization

, 2015
International audienceA rapid development of gadolinium-based nanoparticles is observed due to their attractive properties as MRI-positive contrast agents.
Bianchi, Andrea, Crémillieux, Yannick, Lux, François, Roux, Stéphane, Sancey, Lucie, Tillement, Olivier   +5 more
core   +3 more sources

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP‐00)

The Prostate, Volume 86, Issue 8, Page 891-899, June 2026.
ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
Liam D. King, David Christie, Daniel Cehic, Wendy Dare, Russ Chess‐Williams, Donna Sellers, Catherine McDermott, Alexandra McCarthy, Shailendra Anoopkumar‐Dukie   +8 more
wiley   +1 more source

Impact of Intraprostatic Simultaneous Integrated Boost on Long‐Term Outcomes in Unfavorable Intermediate‐Risk Prostate Cancer Treated With Dose‐Escalated Radiotherapy and Short‐Term Androgen Deprivation Therapy

The Prostate, Volume 86, Issue 8, Page 961-969, June 2026.
ABSTRACT Background Unfavorable intermediate‐risk prostate cancer (UIR‐PCa) represents a biologically heterogeneous subgroup with a higher risk of recurrence compared with favorable intermediate‐risk disease. Contemporary management frequently includes dose‐escalated radiotherapy (RT) combined with short‐term androgen deprivation therapy (ADT). Whether
Cem Onal, Aysenur Elmali, Birhan Demirhan, Ertugrul Senturk, Petek Erpolat, Ozan Cem Guler   +5 more
wiley   +1 more source

Synergistic Effects of DNA‐PKcs Inhibition and Radiotherapy in Esophageal Squamous Cell Carcinoma

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Radiotherapy induces double‐strand DNA breaks in esophageal squamous cell carcinoma, triggering DNA‐PKcs phosphorylation and activating the non‐homologous end joining (NHEJ) repair pathway, which contributes to radioresistance. Inhibiting DNA‐PKcs disrupts this repair mechanism, enhancing radiosensitivity by blocking NHEJ, amplifying DNA damage, and ...
Jiekun Qian, Guoliang Liao, Jianting Du, Maojie Pan, Maohui Chen, Long Wu, Xin Yan, Chun Chen, Bin Zheng, Zhang Yang   +9 more
wiley   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source