Results 91 to 100 of about 14,471 (229)

Laser‐Synthesized Carbon‐Coated Elemental Bismuth Nanoparticles for Sustained Reactive Oxygen Species Generation Under Visible‐Light Irradiation

Small, EarlyView.
Femtosecond laser ablation of bismuth in acetone yields carbon‐coated nanoparticles with a metallic Bi0 core and an amorphous carbon shell. The core‐shell architecture preserves visible‐light‐driven redox activity and enables sustained hydroxyl‐radical generation.
Pavel Bezrukov, Sravan Sangeeth Surendran, Andrey Machnev, Andrei Pastukhov, Alexander Gumennik, Andrei Kabashin, Pavel Ginzburg   +6 more
wiley   +1 more source

PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors

, 2018
KRAS mutations in non–small cell lung cancer (NSCLC) cause increased levels of DNA damage and replication stress, suggesting that inhibition of the DNA damage response (DDR) is a promising strategy for radiosensitization of NSCLC. This study investigates
David Karnak, Jonathan Maybaum, Qiang Zhang, Daniel R. Wahl, Joshua D. Parsels, Leslie A. Parsels, Theodore S. Lawrence, Jonathan Vélez-Padilla, Meredith A. Morgan, Zachery R. Reichert, Mark J. O'Connor   +10 more
core   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition.

, 2014
BACKGROUND AND PURPOSE Cisplatin activates ataxia-telangiectasia-mutated (ATM), a protein with roles in DNA repair, cell cycle progression and autophagy.
Toulany M, Holler M, Mihatsch J, Chaachouay H, Rodemann HP   +4 more
core   +1 more source

Replication Stress in Cancer: Mechanistic Insights and Therapeutic Opportunities for Radiosensitization

Current Issues in Molecular Biology
Replication stress (RS) is a hallmark of cancer, largely driven by oncogene activation. Due to high levels of RS, cancer cells depend heavily on the RS response mechanisms to avoid DNA damage. This dependency creates a therapeutic opportunity that can be
Spyridon N. Vasilopoulos, Ioanna Tremi, Ioly Kotta-Loizou, Angeliki Gkikoudi, Ourania E. Tsitsilonis, Sophia Havaki, Alexandros G. Georgakilas   +6 more
doaj   +1 more source

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53

, 2006
Histone deacetylase inhibitors (HDI) are emerging as potentially useful components of the anticancer armamentarium and as useful tools to dissect mechanistic pathways.
Wu, Hong Gyun, Kao, Gary D, Park, Charn Il, Kim, Jae Sung, Kim, In Ah, Kim, Jin Ho, Kim, Il Han, Chie, Eui Kyu, Ha, Sung Whan, Shin, Jin Hee   +9 more
core   +1 more source

Radiosensitization of FM3A Cells by 5-Fluorouracil Plus Cisplatin [PDF]

The effects of radiation in combination with either 5-fluorouracil (5-FU), cisplatin (CDDP), or both on FM3A cell survival were evaluated in vitro. Cell survival following treatment with the drugs and/or radiation was determined by colony formation ...
Sakai, Kunio, 52862, 52865, Fujita, Shozo, Sueyama, Hiroo, 52866, 52863, 52864, Ohkubo, Masaki, Higuchi, Shoichi   +9 more
core   +1 more source