Results 101 to 110 of about 14,471 (229)

Nimotuzumab Combined With Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma and Nasopharyngeal Carcinoma: A Systematic Review and Meta‐Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This meta‐analysis of 18 studies (3962 patients) demonstrates that nimotuzumab combined with chemoradiotherapy significantly improves overall survival and progression‐free survival in locally advanced head and neck squamous cell carcinoma, without increasing severe toxicity.
Chengzheng Bao, Yue Zhang, Xiang Fei, Kaifeng Ji, Ming Jia, Zhijun Li, Chao Bian   +6 more
wiley   +1 more source

Supplementary Figure 5 from Inhibition of DNA Double-Strand Break Repair by the Dual PI3K/mTOR Inhibitor NVP-BEZ235 as a Strategy for Radiosensitization of Glioblastoma

, 2014
PDF file - 23K, Radiosensitization of normal human astrocytes (NHA) with NVP-BEZ235.
Carlos Rodrigo Gil del Alcazar (14990084), Jingsheng Yan (292464), Xiaohuan Gao (14990090), Molly Catherine Hardebeck (14990087), Bipasha Mukherjee (2317201), Xian-Jin Xie (214672), Sandeep Burma (122515), Nozomi Tomimatsu (14898302), Amyn A. Habib (14879630), Robert Bachoo (11426939), Li Li (14993)   +10 more
core   +1 more source

Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer

Cancer Science, EarlyView.
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang, Puyuan Chen, Yawen Zheng, Feiyue Shi, Min Wang, Luwei Xu, Xiaowei Wei, Xiumei Wang   +7 more
wiley   +1 more source

Musashi‐1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model

Cancer Science, EarlyView.
Fractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park   +5 more
wiley   +1 more source

CELL-SPECIFIC RADIOSENSITIZATION BY GOLD NANOPARTICLES AT MEGAVOLTAGE RADIATION ENERGIES

, 2011
PurposeGold nanoparticles (GNPs) have been shown to cause sensitization with kilovoltage (kV) radiation. Differences in the absorption coefficient between gold and soft tissue, as a function of photon energy, predict that maximum enhancement should occur
Wendy B. Hyland, Jain, Suneil, Prise, Kevin M., Hirst, David G., Butterworth, Karl T., Hounsell, Alan R., McMahon, Stephen J., Glenn R. Dickson, Stephen J. McMahon, Kevin M. Prise, Jonathan A. Coulter, Mark F. Muir, Fred J. Currell, Hyland, Wendy B., Suneil Jain, David G. Hirst, Joe M. O’Sullivan, Dickson, Glenn R., O'Sullivan, Joe M., Muir, Mark F., Alan R. Hounsell, Coulter, Jonathan A., Karl T. Butterworth, Currell, Fred J.; id_orcid   +23 more
core   +1 more source

Gemcitabine-mediated radiosensitization: The effects of p53 expression and mismatch repair.

, 2003
Gemcitabine (dFdCyd) is a nucleoside analog that has demonstrated synergistic cell killing with ionizing radiation (termed radiosensitization) in a variety of solid tumor cells. The diphosphate derivative, dFdCDP, inhibits ribonucleotide reductase, which
Robinson, Blaine Walker
core   +2 more sources

Avian Eggshell Evolutionary Adaptations Inform Biomimetic Strategies for Next‑Generation Precision Cancer Theranostics

Advanced Oncology, Volume 1, Issue 1, December 2026.
ABSTRACT The avian eggshell is a sophisticated, multi‐functional biocomposite and, more importantly, an autonomous life‐support system evolved to safeguard embryonic development across dynamic and hostile environments. Discussing eggshell‐inspired biomaterials beyond simple structural imitation, this review translates these evolutionary survival ...
Zhiqiang Liu, Sida Ling, Mengqi Zhao, Chunyan Zhu, Yaoye Zhou, Hengquan Hou, Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Zuyong Wang, Swee Hin Teoh   +11 more
wiley   +1 more source

Supplementary Figures S1-S4 from Molecularly Targeted Radiosensitization of Human Prostate Cancer by Modulating Inhibitor of Apoptosis

, 2008
Supplementary Figures S1-S4 from Molecularly Targeted Radiosensitization of Human Prostate Cancer by Modulating Inhibitor of ...
Liang Xu (102656), Wenhua Tang (235444), Meilan Liu (739272), Jeffrey DeSano (235443), Ezra Burstein (235454), Kenneth Pienta (4176607), Theodore Lawrence (14973694), Mary Davis (530294), Yao Dai (235442)   +8 more
core   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Ultrasmall Gold Nanoclusters Inhibit Colon Cancer Cell Growth

Aggregate, Volume 7, Issue 11, November 2026.
Ultrasmall Au25(p‐MBA)18 nanoclusters and larger gold nanoparticles functionalized with the same ligands exhibit contrasting cytotoxic effects across multiple colorectal cancer (CRC) cell lines. Scanning transmission electron microscopy enables visualization of the intracellular localization of Au25(p‐MBA)18 nanoclusters.
Qing Wang, Wenya Li, Qingyuan Li, Yingying Li, Yixia Chai, Changhua Wang, Xitong Zhang, Yitao Cao, Side Liu, Peng Zhang   +9 more
wiley   +1 more source