Results 81 to 90 of about 14,471 (229)

Synergistic Cemof Nanoplatform For Oscc Radiosensitization And Immune Microenvironment Remodeling

International Dental Journal
Aim or purpose: To address the dual challenges of radiotherapy resistance and immunosuppressive microenvironments in oral squamous cell carcinoma (OSCC), this study developed a cerium-based metal-organic framework (CeMOF) nanoplatform integrating ...
Baihui Miao, He Wang, Qing Li
doaj   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

The Choice Between Definitive Radiotherapy and Surgery for Cervical Cancer With Different Histology in Current Clinical Practice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT For cervical cancer, the choice between definitive radiotherapy (RT) and surgery has long been a topic of debate. Clinical factors, including histology and tumor burden, have been examined in prior studies. Given recent advances in RT and the incorporation of concurrent chemotherapy, our study seeks to assess the optimal treatment modality for
Yu‐Lun Wu, Chen‐Wei Ho, Wen‐Shiung Liou, Chun‐Hao Yin, Jin‐Shuen Chen, Yao‐Shen Chen, Yu‐Wei Lin, Ju‐Chun Chien   +7 more
wiley   +1 more source

Radiobiological perspective on metrics for quantifying dose enhancement effects of High-Z nanoparticles

Frontiers in Nanotechnology
High atomic number (high-Z) metal nanoparticles (NPs) have emerged as transformative radiosensitizers in cancer radiotherapy, offering the potential to amplify tumor-specific radiation effects while sparing healthy tissues.
Yan Luo
doaj   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

The combination of rosuvastatin and meloxicam enhances the radiotherapy efficacy of MCF7, T-47D, and MDA-MB-231 breast cancer cell lines

Research in Pharmaceutical Sciences
Background and purpose: Radiotherapy is an essential treatment for breast cancer, but radioresistance remains a major obstacle. Studies suggest that statins and cyclooxygenase-2 (COX-2) inhibitors can enhance radiotherapy, yet few have examined their ...
Arvin Naeimi, Hamid Saeidi Saedi, Amir Mohsen Bakhtiyari, Kimia Shabani, Zahra Babajani, Mona Haddad Zahmatkesh   +5 more
doaj   +1 more source

Anti-Tumor and Radiosensitization Effects of N-Butylidenephthalide on Human Breast Cancer Cells

Molecules, 2018
N-Butylidenephthalide (BP), which is extracted from a traditional Chinese medicine, Radix Angelica Sinensis (danggui), displays antitumor activity against various cancer cell lines.
Yi-Ju Su, Sung-Ying Huang, Yu-Hui Ni, Kuan-Fu Liao, Sheng-Chun Chiu   +4 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source

Differences in Heat-induced Cell Killing as Determined in Three Mammalian Cell Lines Do Not Correspond with the Extent of Heat Radiosensitization

, 1986
Three different cell lines, Ehrlich ascites tumour (EAT) cells, HeLa S3 cells and LM mouse fibroblasts, were used to investigate whether or not the extent of heat killing (44°C) and heat radio-sensitization (44°C before 0–6 Gy X-irradiation) are related.
Jorritsma, J. B. M., Konings, A. W. T., Kampinga, H. H.; id_orcid, Burgman, P.   +3 more
core   +1 more source

Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat modelCentral MessagePerspective

JTCVS Open
Objective: To test the safety and efficacy of combination treatment for pleural mesothelioma (PM) with intracavitary cisplatin-fibrin (cis-fib) plus hemithoracic irradiation (IR) applied after lung-sparing surgery in an orthotopic immunocompetent rat ...
Michaela B. Kirschner, PhD, Mayura Meerang, PhD, Vanessa Orlowski, Katarzyna Furrer, MD, Fabienne Tschanz, PhD, Ivo Grgic, PhD, Virginia Cecconi, PhD, Maries van den Broek, PhD, Matthias Guckenberger, MD, Martin Pruschy, MD, Olivia Lauk, MD, Isabelle Opitz, MD   +11 more
doaj   +1 more source