Results 131 to 140 of about 10,067 (250)

11CO2 Fixation: A Renaissance in PET Radiochemistry [PDF]

, 2013
Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide.
Collier, Thomas L, Holland, Jason P, Hooker, Jacob M, Liang, Steven, Rotstein, Benjamin H, Vasdev, Neil, Wilson, Alan A.   +6 more
core   +1 more source

PET imaging of steroid hormone receptor expression [PDF]

, 2015
Steroid hormone receptor (SHR) expression and changes in SHR expression compared to basal levels, whether upregulated, down-regulated, or mutated, form a distinguishing feature of some breast, ovarian, and prostate cancers.
Aboagye, EO, Allott, L, Carroll, L, Smith, G   +3 more
core   +2 more sources

Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel

Scientific Reports
The design and radiosynthesis of [18F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step radiochemical approach that led to the radiosynthesis of [18F]NT376 in a good radiochemical yield, (17.0 ±
Sulan Xu, Chun-Han Huang, Christopher Eyermann, Georgios V. Georgakis, Nashaat Turkman   +4 more
doaj   +1 more source

[18F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model. [PDF]

, 2014
International audienceINTRODUCTION: Rheumatoid arthritis (RA) is a chronic disease, affecting 0.5-1% of adults in industrialized countries, in which systemic inflammation and synovitis drive joint destruction.
Bernards, Nicholas, Boisgard, Raphael, Dollé, Frédéric, Pottier, Géraldine   +3 more
core   +4 more sources

Radiosynthesis and evaluation of a fluorine-18 radiotracer [¹⁸F]FS1P1 for imaging sphingosine-1-phosphate receptor 1

, 2021
Lin Qiu, Hao Jiang, Yanbo Yu, Jiwei Gu, Jinzhi Wang, Haiyang Zhao, Tianyu Huang, Robert J. Gropler, Robyn S. Klein, Joel S. Perlmutter, Zhude Tu   +10 more
openalex   +2 more sources

In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999. [PDF]

, 2013
INTRODUCTION: We examined whether [(18)F]LBT-999 ((E)-N-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4'-tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine transporter (DAT) in the healthy rat ...
Chalon, Sylvie, Deloye, Jean-Bernard, Galineau, Laurant, Garreau, Lucette, Guilloteau, Denis, Sérrière, Sophie, Tauber, Clovis, Vercouillie, Johnny   +7 more
core   +1 more source

Preparation of 18F-Labeled Styryl Nitrogenous Heterocycles

Journal of Isotopes, 2018
To synthesize ［18F］Florbetapir, 18F-SPy5, 18F-SPm2 and 18F-SPm5, 18F was labeled by nucleophilic substitution taking p-tosyloxy (OTs) as a leaving group to radiosynthesis ［18F］Florbetapir for represent.
LIU Yinli1;LI Zhongyong1,2
doaj   +1 more source

(−)‐[ 18 F]Flubatine: evaluation in rhesus monkeys and a report of the first fully automated radiosynthesis validated for clinical use [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/101867/1/jlcr3069 ...
Albin, Roger L., Hockley, Brian G., Kilbourn, Michael R., Quesada, Carole, Scott, Peter J. H., Sherman, Phillip, Stewart, Megan N.   +6 more
core   +1 more source

GMP compliant simplified fast and high yielding automated synthesis of [18F]fallypride without the need of HPLC purification

EJNMMI Radiopharmacy and Chemistry
Background [18F]Fallypride PET has been used to study D2/3 receptor occupancy and density in neuropsychiatric disorders including Huntington’s disease (HD) and aging in humans.
Ammar Alfteimi, Yi Zhao, Ulf Lützen, Alexander Helm, Michael Jüptner, Maaz Zuhayra   +5 more
doaj   +1 more source

Radiosynthesis and Evaluation of Talazoparib and Its Derivatives as PARP-1-Targeting Agents [PDF]

, 2021
Dong Zhou, Huaping Chen, Cedric Mpoy, Sadia Afrin, Buck E. Rogers, Joel R. Garbow, John A. Katzenellenbogen, Jinbin Xu   +7 more
openalex   +1 more source