Results 111 to 120 of about 8,638 (225)

Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel

Scientific Reports
The design and radiosynthesis of [18F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step radiochemical approach that led to the radiosynthesis of [18F]NT376 in a good radiochemical yield, (17.0 ±
Sulan Xu, Chun-Han Huang, Christopher Eyermann, Georgios V. Georgakis, Nashaat Turkman   +4 more
doaj   +1 more source

In vivo characterisation of a therapeutically relevant self-assembling 18 F-labelled β-sheet forming peptide and its hydrogel using positron emission tomography [PDF]

, 2017
Positron emission tomography (PET) and fluorescence labelling have been used to assess the pharmacokinetics, biodistribution and eventual fate of a hydrogel-forming nonapeptide, FEFKFEFKK (F9) in healthy mice, using 18F-labelled and ...
Castillo Diaz, Castillo Diaz, Chen, Dasgupta, Di, Elsawy, Hall, Jonker, Katsila, Kharasch, Morris, Mujeeb, Roberts, Szkolar, Tang, Wan   +15 more
core   +1 more source

Synthesis, in vitro evaluation, and radiolabeling of fluorinated puromycin analogues: potential candidates for PET imaging of protein synthesis [PDF]

, 2016
There is currently no ideal radiotracer for imaging protein synthesis rate (PSR) by positron emission tomography (PET). Existing fluorine-18 labelled amino acid-based radiotracers predominantly visualize amino acid transporter processes, and in many ...
Alan C. Perkins, Carmen Tong, Franklin I. Aigbirhio, Helen M. Betts, Ishiwata K., Lampinen J., Philip J. Hill, Ramla O. Awais, Selena Milicevic Sephton   +8 more
core   +3 more sources

Preparation of 18F-Labeled Styryl Nitrogenous Heterocycles

Journal of Isotopes, 2018
To synthesize ［18F］Florbetapir, 18F-SPy5, 18F-SPm2 and 18F-SPm5, 18F was labeled by nucleophilic substitution taking p-tosyloxy (OTs) as a leaving group to radiosynthesis ［18F］Florbetapir for represent.
LIU Yinli1;LI Zhongyong1,2
doaj   +1 more source

GMP compliant simplified fast and high yielding automated synthesis of [18F]fallypride without the need of HPLC purification

EJNMMI Radiopharmacy and Chemistry
Background [18F]Fallypride PET has been used to study D2/3 receptor occupancy and density in neuropsychiatric disorders including Huntington’s disease (HD) and aging in humans.
Ammar Alfteimi, Yi Zhao, Ulf Lützen, Alexander Helm, Michael Jüptner, Maaz Zuhayra   +5 more
doaj   +1 more source

Untersuchungen zur Darstellung trägerarm 73,75Se-markierter Tracer für in vivo Untersuchungen [PDF]

, 2013
With the growing importance of positron emission tomography (PET) for in vivo imaging in diagnostic medicine there is great interest of developing new labelling methods for the positron emitter selenium-73.
Helfer, Andreas
core  

In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography [PDF]

, 2003
Background and aims: Positron emission tomography (PET) using 18F labelled 2-fluoro-2-deoxy-D-glucose (18FDG) is an established imaging tool, although the recent development of a biologically stable thymidine analogue [18F] 3'-deoxy-3-fluorothymidine ...
Costa, D.C., Ell, P.J., Francis, D.L., Freeman, A., Luthra, S.K., Novelli, M., Taylor, I., Visvikis, D.   +7 more
core  

Business Sphere, Vol. 19, no.1 [PDF]

, 2007
Ethanol, the clean-burning, high octane fuel distilled from Iowa’s corn fields, has the potential to free the U.S. from its foreign oil dependence. Transforming corn into ethanol, however, takes energy, usually in the form of natural gas or coal.

core  

Automation of 4-[18F]fluorogabapentin radiosynthesis

Nuclear Medicine and Biology, 2021
Yu-Peng Zhou, Pedro Brugarolas
openaire   +1 more source

Fully Automated Production of (((S)-1-Carboxy-5-(6-([¹⁸F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-l-glutamic Acid ([¹⁸F]JK-PSMA-7)

Pharmaceuticals
Background: The radiotracer [18F]JK-PSMA-7, a prostate cancer imaging agent for positron emission tomography (PET), was previously synthesized by indirect radiofluorination using an 18F-labeled active ester as a prosthetic group, which had to be isolated
Philipp Krapf, Thomas Wicher, Boris D. Zlatopolskiy, Johannes Ermert, Bernd Neumaier   +4 more
doaj   +1 more source