Results 111 to 120 of about 6,098 (221)

GMP compliant simplified fast and high yielding automated synthesis of [18F]fallypride without the need of HPLC purification

EJNMMI Radiopharmacy and Chemistry
Background [18F]Fallypride PET has been used to study D2/3 receptor occupancy and density in neuropsychiatric disorders including Huntington’s disease (HD) and aging in humans.
Ammar Alfteimi, Yi Zhao, Ulf Lützen, Alexander Helm, Michael Jüptner, Maaz Zuhayra   +5 more
doaj   +1 more source

Cyclotron production of short-lived radionuclides and labelled compounds for use in biomedical research and clinical diagnosis [PDF]

, 1994
The works submitted in this thesis cover the development of methods for the production in a cyclotron of a variety of radionuclides and their incorporation in radio-labelled compounds for use in biomedical research. In addition, papers are included which
Clark, John Charles
core  

Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate.

, 2022
Background/Aims: [18F]Fluoroalkyl groups are essential labeling units because they are considered as surrogates for [11C]methyl moieties, and are coupled to the same functional units as the [11C]methyl group.
Wakana, Mori, 1054109, Masanao, Ogawa, 1054106, 1054105, 1054108, 1054107, 1054102, 1054101, 1054104, 1054103, 1054100, Kazunori, Kawamura, Nobuki, Nengaki, Zhang, Ming-Rong, Ohkubo, Takayuki, Hiroki, Hashimoto, 1054112, Masayuki, Fujinaga, 1054098, 1054097, Kurihara, Yusuke, 1054111, 1054099, 1054110, 1054094, 1054093, 1054096, 1054095, Kaito, Tsukagoe   +29 more
core  

Radiosynthesis and Validation of 18F-FP-CMT, a Phenyltropane with Superior Properties for Imaging the Dopamine Transporter in Living Brain

, 2014
To date there is no validated, 18F-labeled dopamine transporter (DAT) radiotracer with a rapid kinetic profile suitable for preclinical small-animal positron emission tomography (PET) studies in rodent models of human basal ganglia disease.
Tschammer, Nuska, Heinrich, Markus R, Prante, Olaf, Maschauer, Simone, Fehler, Stefanie K, Riss, Patrick J, Cumming, Paul, Kuwert, Torsten   +7 more
core   +1 more source

Radiosynthesis of [18F]-flumazenil Using an Isotopic Approach

Indian Journal of Nuclear Medicine
Background: Fluorine-18 ( 18 F) flumazenil (FMZ) has been synthesized using various precursors, and its role has been explored in imaging Gamma-aminobutyric acid-A receptors.
Thakur, Riptee, Kumar, Aishwarya, Joshi, Raman Kumar, Kumar, Pardeep   +3 more
openaire   +2 more sources

Radiochemical yield of [¹⁸F]SFB by one-pot radiosynthesis under different water content conditions (data are the mean ± S.D., n = 3).

, 2016
Radiochemical yield of [18F]SFB by one-pot radiosynthesis under different water content conditions (data are the mean ± S.D., n = 3).
Ren Iwata (812734), Hiroyuki Kimura (261126), Yuji Kuge (458337), Kenji Arimitsu (180751), Masahiro Ono (106488), Hiroaki Nakanishi (2727712), Eiichi Ozeki (1765183), Hidekazu Saiki (3154818), Kenji Tomatsu (3154821), Hidekazu Kawashima (2259781), Hideo Saji (458369)   +10 more
core   +1 more source

Design, Radiosynthesis, and Biodistribution of a New Potent and Selective Ligand for in Vivo Imaging of the Adenosine A_2A Receptor System Using Positron Emission Tomography

, 2016
Design, Radiosynthesis, and Biodistribution of a New Potent and Selective Ligand for in Vivo Imaging of the Adenosine A2A Receptor System Using Positron Emission ...
Barbara Cacciari (832354), Sergio Todde (3011961), Marzia Galli Kienle (3011958), Pasquale Simonelli (3011952), Katia Varani (289338), Mario Matarrese (2434324), Pier Giovanni Baraldi (1570153), Angela Monopoli (125880), Assunta Carpinelli (3011955), Ferruccio Fazio (2434306), Rosa Maria Moresco (2434318), Fulvio Magni (627391), Giampiero Spalluto (832355)   +12 more
core   +1 more source

Automated and manual synthesis of [68Ga]Ga-DOTA-4AH29 intended for PET-imaging of FAP-expression

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein is a well-established target for tumour imaging, and single-domain antibodies (sdAb) offer favourable pharmacokinetic properties for PET applications.
Marion Berdal, Surasa Nagachinta, Ximena Langsberg, Vaiva Gaspariunaite, Sam Massa, Ana Rita Pombo Antunes, Dimitrios Mantzilas, Matthias D’Huyvetter, Laurent Navarro   +8 more
doaj   +1 more source

Radiosynthesis and biological evaluation of L- and D-S-(3-[ 18F]fluoropropyl)homocysteine for tumor imaging using positron emission tomography

, 2011
Radiosynthesis and biological evaluation of L- and D-S-(3-[ 18F]fluoropropyl)homocysteine for tumor imaging using positron emission ...
T Jackson (13328955), R Hicks (9869540), R Shepherd (9858140), P Berghofer (13681072), Delphine Denoyer (13066626), C Fookes (13460562), I Greguric (13681099), D Dorow (13704913), M C Gregoire (13681096), T Bourdier (13706701), A Katsifis (13279986)   +10 more
core  

Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation.

, 2012
The histamine H(3) receptor (H(3)R) plays a role in cognition and memory processes and is implicated in different neurological disorders, including Alzheimer's disease, schizophrenia, and narcolepsy.
Selivanova SV, Isensee K, Stark H, Combe F, Krämer SD, Honer M, Ametamey SM, Schubiger PA   +7 more
core   +1 more source