Results 1 to 10 of about 1,937 (104)

Fully automated radiosynthesis of [18F]mG4P027 for mGluR4 imaging [PDF]

iRADIOLOGY, 2023
Background Fluorine‐18 labeled N‐(4‐chloro‐3‐(((fluoro‐18F)methyl‐d2)thio)phenyl)picolinamide, [18F]mG4P027, is a potent positron emission tomography (PET) radiotracer for mGluR4.
Sung‐Hyun Moon, Georges El Fakhri, Zhaoda Zhang, Anna‐Liisa Brownell, Junfeng Wang   +4 more
doaj   +3 more sources

Automated Radiosynthesis, Preliminary In Vitro/In Vivo Characterization of OncoFAP-Based Radiopharmaceuticals for Cancer Imaging and Therapy [PDF]

Pharmaceuticals, 2022
FAP-targeted radiopharmaceuticals represent a breakthrough in cancer imaging and a viable option for therapeutic applications. OncoFAP is an ultra-high-affinity ligand of FAP with a dissociation constant of 680 pM.
Francesco Bartoli, Philip Elsinga, Luiza Reali Nazario, Aureliano Zana, Andrea Galbiati, Jacopo Millul, Francesca Migliorini, Samuele Cazzamalli, Dario Neri, Riemer H. J. A. Slart, Paola Anna Erba   +10 more
doaj   +4 more sources

Automated radiosynthesis and biodistribution of [18F]fluoroflutamide [PDF]

EJNMMI Radiopharmacy and Chemistry
Background The androgen receptor (AR) is upregulated in multiple cancers, such as salivary gland cancer, glioblastoma, triple-negative breast cancer, and, most commonly, prostate cancer.
Gina Kaup, Jason Anthony Witek, Shelbie Jaylene Cingoranelli, Jenelle Stauff, David Raffel, Allen Frederick Brooks, Peter James Henry Scott, Jay Samuel Wright   +7 more
doaj   +2 more sources

Fully automated radiosynthesis of [68Ga]Ga-FAPI-46 with cyclotron produced gallium [PDF]

EJNMMI Radiopharmacy and Chemistry, 2023
Background Radiopharmaceuticals capable of targeting the fibroblast activation protein have become widely utilized in the research realm as well as show great promise to be commercialized; with [68Ga]Ga-FAPI-46 being one of the most widely utilized ...
Adam J. Rosenberg, Yiu-Yin Cheung, Fei Liu, Carina Sollert, Todd E. Peterson, Jonathan A. Kropski   +5 more
doaj   +2 more sources

Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats [PDF]

Frontiers in Pharmacology
ObjectiveTo optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent 18F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats.MethodsA more electron-deficient nitropyridine was ...
Yingtong Lu, Yan Cui, Lu Hou, Yuanfang Jiang, Jingjie Shang, Lu Wang, Hao Xu, Weijian Ye, Yang Qiu, Bin Guo   +9 more
doaj   +2 more sources

Automated radiosynthesis of 2-[18F]BPA for PET-based planning of boron neutron capture therapy (BNCT): rational precursor design, radiofluorination, and characterization of methodology [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Boron neutron capture therapy relies on the selective accumulation of boron-containing compounds in tumor tissue, making accurate quantification of boron distribution essential for effective treatment planning.
Vincenzo Paolillo, Cong-Dat Pham, Robert Ta, Dimitra K. Georgiou, Henry Charles Manning   +4 more
doaj   +2 more sources

Automated radiosynthesis and clinical experience of [18F]SMBT-1 PET imaging for in vivo evaluation of reactive astrocyte in Parkinson's disease: a pilot study [PDF]

Frontiers in Nuclear Medicine
BackgroundNeuroinflammation plays an important role in progression of Parkinson disease (PD). [18F]SMBT-1 is a promising novel radiotracer for in vivo evaluation of reactive astrogliosis.MethodsThe automated radiosynthesis of [18F]SMBT-1 was optimized ...
Peerapon Kiatkittikul, Pradith Lerdsirisuk, Laksika Bhuthathorn, Arthita Choolam, Attapon Jantarato, Pattanapong Kongsakorn, Wisakha Chintawan, Thanapon Sringam, Nirawan Fonghoi, Saiphet Vanprom, Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Chetsadaporn Promteangtrong   +13 more
doaj   +2 more sources

Development of an automated radiosynthesis for [68Ga]Ga-NODAGA[40Lys]-Exendin-4 in sodium acetate buffer [PDF]

EJNMMI Radiopharmacy and Chemistry
Background [68Ga]Ga-NODAGA[40Lys]-Exendin-4 (68Ga-Ex-4) is a new PET radiopharmaceutical targeting GLP-1-R that showed great specificity and sensitivity in the topographic diagnosis of benign insulinoma.
Maïlys Ragot, Pauline Reynaud-Orhon, Alban Revy, Marie Batisse-Lignier, Valentin Brusseau, Antony Kelly, Hosameldin Otman, Florent Cachin, Marion Chanchou, Sophie Levesque, Marion Tempier   +10 more
doaj   +2 more sources

High-yield, standardised automated radiosynthesis process for routine clinical insulinoma PET with [⁶⁸Ga]Ga-NODAGA-exendin-4 [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Insulinoma is a rare pancreatic neuroendocrine tumour characterised by inappropriate insulin secretion and recurrent hypoglycaemia. Owing to their small size and intrapancreatic localisation, insulinomas are frequently difficult to detect ...
Elodie Duray, Matthieu Sacrez, Marine Hawotte, Charlotte Collet, Christian Vanasschen, Nicolas Veran, Corentin Warnier   +6 more
doaj   +2 more sources

Production of 211At and automated radiosynthesis of [211At]MABG via electrophilic astatodesilylation [PDF]

EJNMMI Radiopharmacy and Chemistry
Background [211At]m-Astatobenzylguanidine ([211At]MABG) has demonstrated potent antitumor efficacy in preclinical models of malignant neuroendocrine tumours including neuroblastoma and pheochromocytoma/paraganglioma.
Yuto Kondo, Taiki Joho, Shigenori Sasaki, Kazumasa Mochizuki, Naoko Hasegawa, Naoyuki Ukon, Ken-ichi Nishijima, Kohshin Washiyama, Hiroshi Tanaka, Tatsuya Higashi, Noriko S. Ishioka, Kazuhiro Takahashi   +11 more
doaj   +2 more sources