Results 1 to 10 of about 6,098 (221)

Fully Automated, High-Dose Radiosynthesis of [¹⁸F]PARPi

Pharmaceuticals, 2022
[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit ...
Anna Pacelli, Fadi Zarrad, Corentin Warnier, Thibault Gendron, Muhammad Otabashi, Charles Vriamont, Alex Jackson, Wolfgang P. Fendler, Ken Herrmann, Michael Nader   +9 more
doaj   +2 more sources

Fully automated radiosynthesis of [18F]mG4P027 for mGluR4 imaging

iRADIOLOGY, 2023
Background Fluorine‐18 labeled N‐(4‐chloro‐3‐(((fluoro‐18F)methyl‐d2)thio)phenyl)picolinamide, [18F]mG4P027, is a potent positron emission tomography (PET) radiotracer for mGluR4.
Junfeng Wang
exaly   +2 more sources

Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein

Applied Sciences (Switzerland), 2014
Two α-synuclein ligands, 3-methoxy-7-nitro-10H-phenothiazine (2a, Ki = 32.1 ± 1.3 nM) and 3-(2-fluoroethoxy)-7-nitro-10H-phenothiazine (2b, Ki = 49.0 ± 4.9 nM), were radiolabeled as potential PET imaging agents by respectively introducing 11C and 18F ...
Paul Kotzbauer, Robert Mach, Zhude Tu
exaly   +3 more sources

Radiosynthesis of [¹⁸F]-Labelled Pro-Nucleotides (ProTides) [PDF]

Molecules, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success.
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell   +7 more
doaj   +5 more sources

Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist

Molecules, 2015
In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. Desmethyl isradipine (4-(benzo[c][1,
Benjamin H Rotstein, Neil Vasdev, Vasily Belov   +2 more
exaly   +3 more sources

Automated radiosynthesis of [11C]morphine for clinical investigation [PDF]

Applied Radiation and Isotopes, 2011
To meet a multiple-dose clinical evaluation of the P-gp modulation of [(11)C]morphine delivery into the human brain, radiosynthesis of [(11)C]morphine was accomplished on an automated system by N-methylation of normorphine with [(11)C]CH(3)I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed.
Evan Kharasch, Robert Mach, Zhude Tu
exaly   +3 more sources

Development and characterization of a novel TDP-43 positron emission tomography tracer: [¹⁸F]JNJ-TDP43-1. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), limbic‐predominant age‐related TDP‐43 encephalopathy (LATE), and Alzheimer's disease (AD) are associated with TAR DNA‐binding protein 43 (TDP‐43) pathology.
Xia CA, Salarian M, Gartshore CJ, Scaglione A, Hayes T, Liu S, Tsai HM, Echavarren J, Cid JM, Matzeu A, Szardenings AK.   +10 more
europepmc   +2 more sources

Efficient one-pot radiosynthesis of the 11C-labeled aquaporin-4 inhibitor TGN-020 [PDF]

EJNMMI Radiopharmacy and Chemistry
Background [11C]TGN-020 has been developed as a positron emission tomography (PET) tracer for imaging aquaporin-4 (AQP4) in the brain and used in clinical studies.
Kazunori Kawamura, Katsushi Kumata, Tomoteru Yamasaki, Masanao Ogawa, Yusuke Kurihara, Nobuki Nengaki, Yukimi Nakamura, Maiko Ono, Yuhei Takado, Hironaka Igarashi, Ming-Rong Zhang   +10 more
doaj   +2 more sources

Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene [PDF]

EJNMMI Radiopharmacy and Chemistry
Background In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18F]10) prosthetic groups, has paved
Catherine G. F. Dickmann, Andrew D. Bond, Selena Milicevic Sephton, Franklin I. Aigbirhio   +3 more
doaj   +2 more sources

Automatic Production of [¹⁸F]F-DOPA Using the Raytest SynChrom R&D Module

Pharmaceuticals, 2022
[18F]F-DOPA is widely used in PET diagnostics. Diseases diagnosed with this tracer are schizophrenia, Parkinson’s disease, gliomas, neuroendocrine tumors, pheochromocytomas, and pancreatic adenocarcinoma.
Paweł Waśniowski, Jolanta Czuczejko, Michał Chuchra, Mateusz Wędrowski, Dawid Marciniak, Stanisław Sobiak, Bogdan Małkowski   +6 more
doaj   +1 more source