Results 1 to 10 of about 8,569 (164)

Efficient one-pot radiosynthesis of the 11C-labeled aquaporin-4 inhibitor TGN-020 [PDF]

EJNMMI Radiopharmacy and Chemistry
Background [11C]TGN-020 has been developed as a positron emission tomography (PET) tracer for imaging aquaporin-4 (AQP4) in the brain and used in clinical studies.
Kazunori Kawamura, Katsushi Kumata, Tomoteru Yamasaki, Masanao Ogawa, Yusuke Kurihara, Nobuki Nengaki, Yukimi Nakamura, Maiko Ono, Yuhei Takado, Hironaka Igarashi, Ming-Rong Zhang   +10 more
doaj   +2 more sources

Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene [PDF]

EJNMMI Radiopharmacy and Chemistry
Background In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18F]10) prosthetic groups, has paved
Catherine G. F. Dickmann, Andrew D. Bond, Selena Milicevic Sephton, Franklin I. Aigbirhio   +3 more
doaj   +2 more sources

Fully Automated, High-Dose Radiosynthesis of [¹⁸F]PARPi

Pharmaceuticals, 2022
[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit ...
Anna Pacelli, Fadi Zarrad, Corentin Warnier, Thibault Gendron, Muhammad Otabashi, Charles Vriamont, Alex Jackson, Wolfgang P. Fendler, Ken Herrmann, Michael Nader   +9 more
doaj   +1 more source

Automatic Production of [¹⁸F]F-DOPA Using the Raytest SynChrom R&D Module

Pharmaceuticals, 2022
[18F]F-DOPA is widely used in PET diagnostics. Diseases diagnosed with this tracer are schizophrenia, Parkinson’s disease, gliomas, neuroendocrine tumors, pheochromocytomas, and pancreatic adenocarcinoma.
Paweł Waśniowski, Jolanta Czuczejko, Michał Chuchra, Mateusz Wędrowski, Dawid Marciniak, Stanisław Sobiak, Bogdan Małkowski   +6 more
doaj   +1 more source

Production of [¹¹C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer

Molecules, 2022
In the last decade, microfluidic techniques have been explored in radiochemistry, and some of them have been implemented in preclinical production. However, these are not suitable and reliable for preparing different types of radiotracers or dose-on ...
Hemantha Mallapura, Laurent Tanguy, Bengt Långström, Ludovic Le Meunier, Christer Halldin, Sangram Nag   +5 more
doaj   +1 more source

Potentials of Alginates as Capping Agent for Oral Colon Delivery of Radiosynthesized Silver Nanoparticles: A Review

Atom Indonesia, 2022
Radiosynthesized silver nanoparticles (AgNPs) offer benefits for treatment of chronic colon inflammation due to their anti-inflammatory activity. Targeted delivery of AgNPs to the colon allows topical treatment at high concentration but at reduced ...
D. P. Perkasa, W. Arozal, M. Suhaeri
doaj   +1 more source

Radiosynthesis and Tumor MicroPET/CT Imaging of 18F-Fluoro­ethoxylerianin, an 18F-Labeled Erianin Analogue

SynOpen, 2022
Erianin is an active constituent of Dendrobium candidum. In this work, 18F-fluoroethoxylerianin ([18F]FEE), a 18F-Labeled erianin analogue, was designed and synthesized to evaluate the properties of erianin and related analogues by in vivo PET imaging ...
Hui Nie, Nian Wang, Jinwen Huang, Zhuang Ni, Kangyan Xue, Lixing Song, Mingwei Wang, Fanhong Wu   +7 more
doaj   +1 more source

Fully automated radiosynthesis of [18F]mG4P027 for mGluR4 imaging

iRADIOLOGY, 2023
Background Fluorine‐18 labeled N‐(4‐chloro‐3‐(((fluoro‐18F)methyl‐d2)thio)phenyl)picolinamide, [18F]mG4P027, is a potent positron emission tomography (PET) radiotracer for mGluR4.
Sung‐Hyun Moon, Georges El Fakhri, Zhaoda Zhang, Anna‐Liisa Brownell, Junfeng Wang   +4 more
doaj   +1 more source

Optimization of the Automated Synthesis of [11C]mHED—Administered and Apparent Molar Activities

Pharmaceuticals, 2019
The tracer [[11C]meta-Hydroxyephedrine ([[11C]mHED) is one of the most applied PET tracers for cardiac imaging, whose radiosynthesis was already reported in 1990.
Chrysoula Vraka, Verena Pichler, Neydher Berroterán-Infante, Tim Wollenweber, Anna Pillinger, Maximilian Hohensinner, Lukas Fetty, Dietrich Beitzke, Xiang Li, Cecile Philippe, Katharina Pallitsch, Markus Mitterhauser, Marcus Hacker, Wolfgang Wadsak   +13 more
doaj   +1 more source

One-pot radioiodination of aryl amines via stable diazonium salts: preparation of 125I-imaging agents [PDF]

, 2017
An operationally simple, one-pot, two-step tandem procedure that allows the incorporation of radioactive iodine into aryl amines via stable diazonium salts is described.
Luthra, Sajinder K., McRobbie, Graeme, Pimlott, Sally L., Sloan, Nikki L., Sutherland, Andrew   +4 more
core   +2 more sources