Results 11 to 20 of about 6,098 (221)

Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide

EJNMMI Radiopharmacy and Chemistry, 2019
Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopramide or other ...
Verena Pichler, Marius Ozenil, Karsten Bamminger, Chrysoula Vraka, Marcus Hacker, Oliver Langer, Wolfgang Wadsak   +6 more
doaj   +2 more sources

Optimization of Automated Radiosynthesis of Gallium-68-Labeled PSMA11 with Two [⁶⁸Ge]Ge/[⁶⁸Ga]Ga Generators: Fractional Elution or Prepurification?

Pharmaceuticals, 2023
Prostate cancer is one of the most common forms of cancer in men. An imaging technique for its diagnosis is [68Ga]-prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) positron emission tomography (PET).
Flore Durieux, Bérengère Dekyndt, Jean-François Legrand, Antoine Rogeau, Emmanuel Malek, Franck Semah, Pascal Odou   +6 more
doaj   +2 more sources

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

EJNMMI Radiopharmacy and Chemistry
Background (S)-[18F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism that plays a key role in several diseases including cancers.
Aurélie Maisonial-Besset, David Kryza, Klaus Kopka, Sophie Levesque, Emmanuel Moreau, Barbara Wenzel, Jean-Michel Chezal   +6 more
doaj   +2 more sources

Production of [¹¹C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer

Molecules, 2022
In the last decade, microfluidic techniques have been explored in radiochemistry, and some of them have been implemented in preclinical production. However, these are not suitable and reliable for preparing different types of radiotracers or dose-on ...
Hemantha Mallapura, Laurent Tanguy, Bengt Långström, Ludovic Le Meunier, Christer Halldin, Sangram Nag   +5 more
doaj   +1 more source

Copper-mediated radiosynthesis of 18F- and 123I-radiolabelled PARP inhibitors [PDF]

, 2022
This thesis aims to develop copper-mediated radiosynthesis to incorporate fluorine-18 and iodine-123 into FDA-approved poly(ADP-ribose) polymerase (PARP) inhibitors for cancer diagnosis and treatment, consisting the development of 18F-radiolabelled ...
Chen, Zijun
core   +1 more source

Radiosynthesis of antitumor spliceosome modulators [PDF]

Applied Radiation and Isotopes, 2011
A set of novel antitumor agents (the sudemycins) has recently been described that are analogs of the natural product FR901464. We report the radiosynthesis of two of these antitumor drug lead compounds, using a three step procedure: (1) ester hydrolysis, (2) Lindlar's catalyst/tritium gas to give a (S,Z)-4-acetoxypent-2-enoic acid derivative, and ...
Tinopiwa, Goronga, Vincent A, Boyd, Chandraiah, Lagisetti, Cynthia, Jeffries, Thomas R, Webb   +4 more
openaire   +2 more sources

Fully Automated, High-Dose Radiosynthesis of [18F]PARPi [PDF]

, 2023
peer reviewed[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the ...
Herrmann, Ken, Fendler, Wolfgang P, Michael Nader, Pacelli, Anna, Warnier, Corentin, Anna Pacelli, Vriamont, Charles, Thibault Gendron, Otabashi, Muhammad, Nader, Michael, Wolfgang P. Fendler, Fadi Zarrad, Alex Jackson, Ken Herrmann, Charles Vriamont, Gendron, Thibault, Zarrad, Fadi, Corentin Warnier, Jackson, Alex, Muhammad Otabashi   +19 more
core   +1 more source

Radiosynthesis and Tumor MicroPET/CT Imaging of 18F-Fluoro­ethoxylerianin, an 18F-Labeled Erianin Analogue

SynOpen, 2022
Erianin is an active constituent of Dendrobium candidum. In this work, 18F-fluoroethoxylerianin ([18F]FEE), a 18F-Labeled erianin analogue, was designed and synthesized to evaluate the properties of erianin and related analogues by in vivo PET imaging ...
Hui Nie, Nian Wang, Jinwen Huang, Zhuang Ni, Kangyan Xue, Lixing Song, Mingwei Wang, Fanhong Wu   +7 more
doaj   +1 more source

Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer

EJNMMI Radiopharmacy and Chemistry, 2023
Background The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga).
Emma Jussing, Mélodie Ferrat, Mohammad M. Moein, Henrik Alfredéen, Tetyana Tegnebratt, Klas Bratteby, Erik Samén, Joachim Feldwisch, Renske Altena, Rimma Axelsson, Thuy A. Tran   +10 more
doaj   +1 more source

Potentials of Alginates as Capping Agent for Oral Colon Delivery of Radiosynthesized Silver Nanoparticles: A Review

Atom Indonesia, 2022
Radiosynthesized silver nanoparticles (AgNPs) offer benefits for treatment of chronic colon inflammation due to their anti-inflammatory activity. Targeted delivery of AgNPs to the colon allows topical treatment at high concentration but at reduced ...
D. P. Perkasa, W. Arozal, M. Suhaeri
doaj   +1 more source