Results 11 to 20 of about 6,285 (179)
Pharmaceuticals, 2023 Prostate cancer is one of the most common forms of cancer in men. An imaging technique for its diagnosis is [68Ga]-prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) positron emission tomography (PET).
Flore Durieux +6 more
doaj +2 more sources
Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide
EJNMMI Radiopharmacy and Chemistry, 2019 Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopramide or other ...
Verena Pichler +6 more
doaj +2 more sources
Copper-Mediated Radiofluorination of the Excitatory Amino Acid Transporter 2 (EAAT2)-Targeted PET Tracer [<sup>18</sup>F]RP-115: Alternate Synthetic Method. [PDF]
J Labelled Comp RadiopharmAn efficient two‐step radiosynthesis of [18F]RP‐115 was developed using copper‐mediated radiofluorination (CMRF) followed by deprotection. In a total 70‐min synthesis time, this approach provided [18F]RP‐115 in high radiochemical yield (52.8% ± 2.1%, decay corrected from stating [18F]fluoride ion) with high molar activity (355 ± 61 GBq/μmol) and ...
Lee SH +9 more
europepmc +2 more sources
Chemoenzymatic Radiosynthesis of a Gluconate Transporter-Targeted In Vivo Bacterial Sensor From Clinical [<sup>18</sup>F]FDG. [PDF]
Angew Chem Int Ed EnglAn efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Lee SH +7 more
europepmc +2 more sources
Development of Radioiodinated Tetrahydropyrazolopyridine Inhibitors Targeting mIDH. [PDF]
J Labelled Comp RadiopharmIodinated tetrahydropyrazolopyridine ligands show enhanced potency and selectivity for mutant IDH1 compared with their fluorinated counterparts and can be efficiently radiolabeled with I‐125, supporting the basis for further evaluation as mIDH1‐targeting radiotheranostic candidates.
Kaur S +7 more
europepmc +2 more sources
Fully Automated, High-Dose Radiosynthesis of [18F]PARPi [PDF]
, 2023 peer reviewed[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the ...
Herrmann, Ken +19 more
core +1 more source
EJNMMI Radiopharmacy and Chemistry, 2023 Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess +5 more
doaj +1 more source
Copper-mediated radiosynthesis of 18F- and 123I-radiolabelled PARP inhibitors [PDF]
, 2022 This thesis aims to develop copper-mediated radiosynthesis to incorporate fluorine-18 and iodine-123 into FDA-approved poly(ADP-ribose) polymerase (PARP) inhibitors for cancer diagnosis and treatment, consisting the development of 18F-radiolabelled ...
core +1 more source
Molecules, 2015 In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. Desmethyl isradipine (4-(benzo[c][1,
Benjamin H. Rotstein +8 more
doaj +1 more source
Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein
Applied Sciences, 2014 Two α-synuclein ligands, 3-methoxy-7-nitro-10H-phenothiazine (2a, Ki = 32.1 ± 1.3 nM) and 3-(2-fluoroethoxy)-7-nitro-10H-phenothiazine (2b, Ki = 49.0 ± 4.9 nM), were radiolabeled as potential PET imaging agents by respectively introducing 11C and 18F ...
Xiang Zhang +8 more
doaj +1 more source