Results 11 to 20 of about 8,638 (225)

Radiosynthesis of [¹⁸F]-Labelled Pro-Nucleotides (ProTides) [PDF]

Molecules, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success.
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell   +7 more
doaj   +5 more sources

Copper-Mediated Radiosynthesis of [¹⁸F]Rucaparib

Organic Letters, 2021
The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation.
Chen, Z, Destro, G, Guibbal, F, Chan, CY, Cornelissen, B, Gouverneur, V   +5 more
openaire   +4 more sources

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism. [PDF]

Adv Sci (Weinh)
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Edwards RS, Hards EM, Dos Santos SN, Greenwood HE, George ME, Emanuelli A, Tanc M, Eykyn TR, Witney TH.   +8 more
europepmc   +2 more sources

Radiosynthesis of antitumor spliceosome modulators [PDF]

Applied Radiation and Isotopes, 2011
A set of novel antitumor agents (the sudemycins) has recently been described that are analogs of the natural product FR901464. We report the radiosynthesis of two of these antitumor drug lead compounds, using a three step procedure: (1) ester hydrolysis, (2) Lindlar's catalyst/tritium gas to give a (S,Z)-4-acetoxypent-2-enoic acid derivative, and ...
Tinopiwa, Goronga, Vincent A, Boyd, Chandraiah, Lagisetti, Cynthia, Jeffries, Thomas R, Webb   +4 more
openaire   +2 more sources

Total Radiosynthesis: Thinking Outside ‘the Box' [PDF]

Australian Journal of Chemistry, 2015
The logic of total synthesis transformed a stagnant state of chemistry when there was a paucity of methods and reagents to synthesize pharmaceuticals. Molecular imaging by positron emission tomography (PET) is now experiencing a renaissance in the way radiopharmaceuticals are synthesized; however, a paradigm shift is desperately needed in the ...
Steven H, Liang, Neil, Vasdev
openaire   +2 more sources

Improved Automated Radiosynthesis of [11C]PBR28 [PDF]

Scientia Pharmaceutica, 2015
Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [(11)C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates.
SAI, Kiran Kumar SOLINGAPURAM, GAGE, Don, NADER, Mike, MACH, Robert H., MINTZ, Akiva   +4 more
openaire   +2 more sources

25 Years of "Loop" Radiochemistry for PET Imaging. [PDF]

J Labelled Comp Radiopharm
While conventional methods to 11C‐ and 18F‐labelled radiopharmaceuticals utilize a vial‐based approach, in the past quarter‐century, a modern, efficient, and cleaner “loop method” has been developed. The radiochemical diversity of reactions synthesized by the loop method are shown.
Murrell E, Khan S, Vasdev N.
europepmc   +2 more sources

A Digital Revolution in Radiosynthesis [PDF]

Journal of Nuclear Medicine, 2013
The rapid growth in the use of PET has led to a concomitant demand in the availability of imaging tracers and research directed toward more efficient and flexible radiosynthetic routes. The production of multiple PET tracers presents a challenge to radiopharmaceutical production facilities;
openaire   +2 more sources

Plug-and-play modules for flexible radiosynthesis [PDF]

Applied Radiation and Isotopes, 2013
We present a plug-and-play radiosynthesis platform and accompanying computer software based on modular subunits that can easily and flexibly be configured to implement a diverse range of radiosynthesis protocols. Modules were developed that perform: (i) reagent storage and delivery, (ii) evaporations and sealed reactions, and (iii) cartridge-based ...
Henry, Herman, Graciela, Flores, Kevin, Quinn, Mark, Eddings, Sebastian, Olma, Melissa D, Moore, Huijiang, Ding, Krzysztof P, Bobinski, Mingwei, Wang, Dirk, Williams, Darin, Wiliams, Clifton Kwang-Fu, Shen, Michael E, Phelps, R, Michael van Dam   +13 more
openaire   +2 more sources

Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. [PDF]

, 2017
Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes
Blecha, Joseph E, Flavell, Robert R, Kwak, Tiffany, Mutch, Christopher A, Neumann, Kiel D, Ohliger, Michael A, Rosenberg, Oren S, Sriram, Renuka, VanBrocklin, Henry F, Villanueva-Meyer, Javier E, Wilson, David M   +10 more
core   +1 more source