Results 21 to 30 of about 8,638 (225)

Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer

EJNMMI Radiopharmacy and Chemistry, 2023
Background The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga).
Emma Jussing, Mélodie Ferrat, Mohammad M. Moein, Henrik Alfredéen, Tetyana Tegnebratt, Klas Bratteby, Erik Samén, Joachim Feldwisch, Renske Altena, Rimma Axelsson, Thuy A. Tran   +10 more
doaj   +1 more source

Rapid iododeboronation with and without gold catalysis: application to radiolabelling of arenes [PDF]

, 2017
Radiopharmaceuticals incorporating radioactive iodine in combination with SPECT imaging play a key role in nuclear medicine, with applications in drug development and disease diagnosis.
Fletcher, Conor, Lee, Ai-Lan, O'Rourke, Kerry M., Pimlott, Sally L., Sutherland, Andrew, Webster, Stacey   +5 more
core   +2 more sources

Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip. [PDF]

PLoS ONE, 2016
In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a ...
Hiroyuki Kimura, Kenji Tomatsu, Hidekazu Saiki, Kenji Arimitsu, Masahiro Ono, Hidekazu Kawashima, Ren Iwata, Hiroaki Nakanishi, Eiichi Ozeki, Yuji Kuge, Hideo Saji   +10 more
doaj   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

Photocatalyzed radiosynthesis of ¹¹C‐phenylacetic acids

Journal of Labelled Compounds and Radiopharmaceuticals, 2023
Fast and straightforward incorporation of radionuclides into pharmaceutically relevant molecules is one of the main barriers to preclinical and clinical tracer research. Late‐stage direct incorporation of cyclotron‐produced [11C]CO2 to afford carbon‐11‐labeled radiopharmaceuticals has the potential to provide ready‐to‐inject positron emission ...
Maxime Munch, Braeden A. Mair, Myriam Adi, Benjamin H. Rotstein   +3 more
openaire   +2 more sources

Automated radiosynthesis of Al[18F]PSMA-11 for large scale routine use. [PDF]

, 2018
Objectives: We report a reproducible automated radiosynthesis for large scale batch production of clinical grade Al[F-18]PSMA-11. Methods: A SynthraFCHOL module was optimized to synthesize Al[F-18]PSMA-11 by Al[F-18]-chelation.
Brans, Boudewijn, Courtyn, Jan, De Man, Kathia, De Vos, Filip, Kersemans, Ken, Moerman, Lieselotte, Piron, Sarah, Van Royen, Tessa   +7 more
core   +1 more source

Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist

Molecules, 2015
In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. Desmethyl isradipine (4-(benzo[c][1,
Benjamin H. Rotstein, Steven H. Liang, Vasily V. Belov, Eli Livni, Dylan B. Levine, Ali A. Bonab, Mikhail I. Papisov, Roy H. Perlis, Neil Vasdev   +8 more
doaj   +1 more source

Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist’s perspective

EJNMMI Radiopharmacy and Chemistry, 2023
Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess, Jörg Zessin, Peter Mäding, Manuela Kuchar, Oliver Kiss, Klaus Kopka   +5 more
doaj   +1 more source

Optimization of Automated Radiosynthesis of Gallium-68-Labeled PSMA11 with Two [⁶⁸Ge]Ge/[⁶⁸Ga]Ga Generators: Fractional Elution or Prepurification?

Pharmaceuticals, 2023
Prostate cancer is one of the most common forms of cancer in men. An imaging technique for its diagnosis is [68Ga]-prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) positron emission tomography (PET).
Flore Durieux, Bérengère Dekyndt, Jean-François Legrand, Antoine Rogeau, Emmanuel Malek, Franck Semah, Pascal Odou   +6 more
doaj   +1 more source

Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography [PDF]

, 2012
Preliminary investigation of the radioiodinated (S,S)-reboxetine analogue, 123I-INER, in baboons showed this tracer to have promise for imaging the noradrenaline transporter (NAT) using single photon emission computed tomography (SPECT).
Baldwin, Baldwin, Chang, Ding, Gandelman, Grandoso, Jobson, Jobson, Jobson, Kanegawa, Kiyono, Kung, Lakshmi, McConathy, Schou, Schou, Schou, Seibyl, Seneca, Smith, Stoddart, Tamagnan, Tavares, Tavares, Tejani-Butt, Zeng, Zoghbi   +26 more
core   +1 more source