Results 21 to 30 of about 6,098 (221)
Copper-Mediated Radiosynthesis of [18F]Rucaparib
Organic Letters, 2021 The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation.
Chen, Z +5 more
openaire +4 more sources
Optimization of the Automated Synthesis of [11C]mHED—Administered and Apparent Molar Activities
Pharmaceuticals, 2019 The tracer [[11C]meta-Hydroxyephedrine ([[11C]mHED) is one of the most applied PET tracers for cardiac imaging, whose radiosynthesis was already reported in 1990.
Chrysoula Vraka +13 more
doaj +1 more source
Plug-and-play modules for flexible radiosynthesis [PDF]
Applied Radiation and Isotopes, 2013 We present a plug-and-play radiosynthesis platform and accompanying computer software based on modular subunits that can easily and flexibly be configured to implement a diverse range of radiosynthesis protocols. Modules were developed that perform: (i) reagent storage and delivery, (ii) evaporations and sealed reactions, and (iii) cartridge-based ...
Henry, Herman +13 more
openaire +2 more sources
Total Radiosynthesis: Thinking Outside ‘the Box’ [PDF]
Australian Journal of Chemistry, 2015 The logic of total synthesis transformed a stagnant state of chemistry when there was a paucity of methods and reagents to synthesize pharmaceuticals. Molecular imaging by positron emission tomography (PET) is now experiencing a renaissance in the way radiopharmaceuticals are synthesized; however, a paradigm shift is desperately needed in the ...
Steven H, Liang, Neil, Vasdev
openaire +2 more sources
A Digital Revolution in Radiosynthesis [PDF]
Journal of Nuclear Medicine, 2013 The rapid growth in the use of PET has led to a concomitant demand in the availability of imaging tracers and research directed toward more efficient and flexible radiosynthetic routes. The production of multiple PET tracers presents a challenge to radiopharmaceutical production facilities;
openaire +2 more sources
Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip. [PDF]
PLoS ONE, 2016 In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a ...
Hiroyuki Kimura +10 more
doaj +1 more source
EJNMMI Radiopharmacy and Chemistry, 2023 Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess +5 more
doaj +1 more source
Improved Automated Radiosynthesis of [11C]PBR28 [PDF]
Scientia Pharmaceutica, 2015 Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [(11)C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates.
SAI, Kiran Kumar SOLINGAPURAM +4 more
openaire +2 more sources
[<sup>11</sup>C]Fentanyl: radiosynthesis and preclinical pet imaging for its pharmacokinetics. [PDF]
EJNMMI Radiopharm ChemBackground Fentanyl is a potent synthetic opioid widely used for pain management and anesthesia, but the high prevalence of its misuse and its key contribution to overdose fatalities in the United States have made it a major drug of concern.
Kim W +11 more
europepmc +2 more sources
An Efficient and Practical Radiosynthesis of [11C]Temozolomide [PDF]
Organic Letters, 2012 Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [(11)C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ. Challenges in [(11)C]TMZ synthesis and reformulation make it difficult for routine production.
Moseley, Christian K. +3 more
openaire +4 more sources