Results 41 to 50 of about 8,638 (225)

Synthesis of [11C]HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson’s disease [PDF]

, 2017
The reference standard (4-((5-chloro-4-(methylamino)pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone (HG-10-102-01) and its precursor (4-((5-chloro-4-(methylamino)pyrimidin-2-yl)amino)-3-hydroxyphenyl)(morpholino)methanone (desmethyl-HG-10-102-
Gao, Mingzhang, Wang, Min, Xu, Zhidong, Zheng, Qi-Huang   +3 more
core   +1 more source

Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression

Molecules, 2013
With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3 ...
Simon M. Ametamey, Silvana Raić-Malić, Stjepko Čermak, Roger Slavik, Adrienne Müller, Thomas Betzel, Andrijana Meščić   +6 more
doaj   +1 more source

Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA

EJNMMI Radiopharmacy and Chemistry, 2021
The neurotracer 6-[18F] FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies.
Ângela C. B. Neves, Ivanna Hrynchak, Inês Fonseca, Vítor H. P. Alves, Mariette M. Pereira, Amílcar Falcão, Antero J. Abrunhosa   +6 more
doaj   +1 more source

τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging [PDF]

, 2011
The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D-2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron ...
Bartenstein, Peter, Höfner, Georg, Iovkova-Berends, Ljuba, Jurkschat, Klaus, Kostikov, Alexey, Rensch, Christian, Schirrmacher, Ralf, Wanner, Klaus Theodor, Wängler, Björn, Wängler, Carmen, Zöller, Thomas   +10 more
core   +2 more sources

Synthesis of No-Carrier-Added 4-[18F]Fluorophenol from 4-Benzyloxyphenyl-(2-thienyl)iodonium Bromide

Molecules, 2011
4-[18F]Fluorophenol is a versatile synthon for the synthesis of more complex radiopharmaceuticals bearing a 4-[18F]fluorophenoxy moiety. In order to prepare 4-[18F]fluorophenol in no-carrier-added (n.c.a.) form only a nucleophilic labelling method ...
Tobias L. Ross, Johannes Ermert, Heinz H. Coenen   +2 more
doaj   +1 more source

Microliter-scale reaction arrays for economical high-throughput experimentation in radiochemistry

Scientific Reports, 2022
The increasing number of positron-emission tomography (PET) tracers being developed to aid drug development and create new diagnostics has led to an increased need for radiosynthesis development and optimization.
Alejandra Rios, Travis S. Holloway, Philip H. Chao, Christian De Caro, Chelsea C. Okoro, R. Michael van Dam   +5 more
doaj   +1 more source

Gamma Radiosynthesis of Colloidal Silver Nanoparticles Stabilized in ι-Carrageenan Under Atmospheric Gases: A Surface Plasmon Resonance Based Study

Atom Indonesia, 2021
ι-Carrageenan is a biodegradable and biocompatible biomaterial which potentially stabilizes colloidal silver nanoparticles (AgNPs). The present study explored gamma radiosynthesis of AgNPs at varied concentration of ι-carrageenan solutions.
D. P. Perkasa, M. Y. Yunus, Y. Warastuti, B. Abbas   +3 more
doaj   +1 more source

Aryl and Alkyl Radiotrifluoromethylation via Metallaphotoredox‐Mediated Radical Cross‐Coupling

Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.
The metallaphotoredox‐mediated radiotrifluoromethylation of arenes and alkanes is described. The operationally simple protocols make use of substrates bearing thianthrenium salts (TT) or N‐hydroxyphthalimide (NHPI) esters and CF218FI. The reaction proceeds through a Ru‐mediated radical formation followed by a Cu‐mediated radical cross‐coupling step and
Lukas Veth, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +2 more sources

A closer look at the synthesis of 2-[18F]fluoroethyl tosylate to minimize the formation of volatile side-products

EJNMMI Radiopharmacy and Chemistry, 2022
Background 2-[18F]Fluoroethyltosylate ([18F]FEtOTs) is a well-known 18F-fluoroalkylating agent widely used to synthesize radiotracers for positron emission tomography.
Martha Sahylí Ortega Pijeira, Sofia Nascimento dos Santos, Yasniel Babi Araujo, André Luis Lapolli, Marcio Nardelli Wandermuren, Zalua Rodríguez Riera, Ivone Carvalho, Philip H. Elsinga, Emerson Soares Bernardes   +8 more
doaj   +1 more source

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis [PDF]

, 2010
An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The unique architecture of the device is centered around a 5-µL coin-shaped
Daridon, Antoine, Elizarov, Arkadij M., Heath, James R., Huang, Jiang, Kolb, Hartmuth C., Padgett, Henry C., Shin, Young Shik, Shu, Jenny, Stout, David, van Dam, R. Michael   +9 more
core   +1 more source