Results 41 to 50 of about 6,098 (221)

[¹⁸F]AB5186 radiosynthesis.

, 2019
[18F]AB5186 radiosynthesis.
Gillian A. Gray (6786209), Sally L. Pimlott (1366506), Christophe Lucatelli (3033765), Lewis Williams (5811791), Mark G. MacAskill (6786194), David E. Newby (411328), Andrew Sutherland (1298325), Timaeus E. F. Morgan (6786200), Carlos José Alcaide-Corral (6786203), Adriana A. S. Tavares (6786212), Tashfeen Walton (6786197), Marc R. Dweck (6786206)   +11 more
core   +1 more source

A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben [PDF]

EJNMMI Radiopharmacy and Chemistry, 2020
Abstract Background Current automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot be economically produced on a conventional
Ksenia Lisova, Jia Wang, Philip H. Chao, R. Michael van Dam   +3 more
openaire   +5 more sources

Radiosynthesis of 2-[¹⁸F]F-PZA.

, 2017
Radiosynthesis of 2-[18F]F-PZA.
Peter Smith-Jones (1339275), Alvaro A. Ordonez (2880218), Fereidoon Daryaee (2566246), Sanjay K. Jain (318001), Hui Wang (30400), Yong S. Chang (3712957), Kayla R. Gogarty (3712960), Lauren E. Bambarger (3712963), Zhuo Zhang (72795), Peter J. Tonge (262325)   +9 more
core   +1 more source

Radiosynthesis of racemic and enantiomerically pure (−)-[18F]flubatine—A promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors

, 2013
(−)-[18F]flubatine is a promising agent for visualization by PET of cerebral α4β2 nicotinic acetylcholine receptors (nAChRs), which are implicated in psychiatric and neurodegenerative disorders.
Fischer, Steffen, Smits, René, Wenzel, Barbara, Funke, Uta, Steinbach, Jörg, Hiller, Achim, Sabri, Osama, Brust, Peter, Hoepping, Alexander, Cumming, Paul   +9 more
core   +1 more source

Multicenter Experience with Good Manufacturing Practice Production of [¹¹C]PiB for Amyloid Positron Emission Tomography Imaging

Pharmaceuticals
Alzheimer’s disease (AD) is a neurodegenerative disorder with increasing global prevalence and accounts for over half of all dementia cases. Early diagnosis is paramount for not only the management of the disease, but also for the development of new AD ...
Anders Bruhn Arndal Andersen, Szabolcs Lehel, Ebbe Klit Grove, Niels Langkjaer, Dan Fuglø, Tri Hien Viet Huynh   +5 more
doaj   +1 more source

Photocatalyzed radiosynthesis of ¹¹C‐phenylacetic acids

Journal of Labelled Compounds and Radiopharmaceuticals, 2023
Fast and straightforward incorporation of radionuclides into pharmaceutically relevant molecules is one of the main barriers to preclinical and clinical tracer research. Late‐stage direct incorporation of cyclotron‐produced [11C]CO2 to afford carbon‐11‐labeled radiopharmaceuticals has the potential to provide ready‐to‐inject positron emission ...
Maxime Munch, Braeden A. Mair, Myriam Adi, Benjamin H. Rotstein   +3 more
openaire   +2 more sources

Scheme 2. Radiosynthesis of iodinated pyridyl benzofuran derivatives.

, 2013
Scheme 2. Radiosynthesis of iodinated pyridyl benzofuran derivatives.
Kenji Matsumura (458367), Yoko Okamoto (350661), Hiroyuki Kimura (261126), Hiroyuki Watanabe (312793), Yan Cheng (149222), Masashi Yoshimura (328061), Masafumi Ihara (302200), Masahiro Ono (106488), Shimpei Iikuni (458368), Ryosuke Takahashi (108123), Hideo Saji (458369)   +10 more
core   +1 more source

Toward Multi(radio)metalated DNA: Enzymatic Polymerization of Metal‐Chelate‐Modified Deoxyribonucleoside Triphosphates

Angewandte Chemie, Volume 138, Issue 27, 1 July 2026.
This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong, François Bénard, David M. Perrin   +2 more
wiley   +2 more sources

Advancements in Microfluidic Cassette-Based iMiDEV™ Technology for Production of L-[¹¹C]Methionine and [¹¹C]Choline

Pharmaceuticals
Microfluidic technology is a highly efficient technique used in positron emission tomography (PET) radiochemical synthesis. This approach enables the precise control of reactant flows and reaction conditions, leading to improved yields and reduced ...
Hemantha Mallapura, Laurent Tanguy, Samin Mahfuz, Lovisa Bylund, Bengt Långström, Christer Halldin, Sangram Nag   +6 more
doaj   +1 more source

Fully automated 18F-fluorination of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) for indirect labelling of nanobodies

Scientific Reports, 2022
N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB), a widely used labeling agent to introduce the 4-[18F]fluorobenzoyl-prosthetic group, is normally obtained in three consecutive steps from [18F]fluoride ion. Here, we describe an efficient one-step labeling
Surasa Nagachinta, Paolo Novelli, Yoann Joyard, Nicolas Maindron, Patrick Riss, Sylvestre Dammicco   +5 more
doaj   +1 more source