Results 41 to 50 of about 6,285 (179)

Toward Multi(radio)metalated DNA: Enzymatic Polymerization of Metal‐Chelate‐Modified Deoxyribonucleoside Triphosphates

Angewandte Chemie, Volume 138, Issue 27, 1 July 2026.
This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong, François Bénard, David M. Perrin   +2 more
wiley   +2 more sources

A Fully Automated Synthesis of 14-(R,S)-[¹⁸F]fluoro-6-thia-heptadecanoic Acid ([¹⁸F]FTHA) on the Elixys Radiosynthesizer

Pharmaceuticals
14-(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA) is a radiocompound for imaging the fatty acid circulation by positron emission tomography.
Usevalad Ustsinau, Lukas Nics, Marcus Hacker, Cecile Philippe   +3 more
doaj   +1 more source

Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R. Flavell, Michael A. Ohliger, Joanne Engel, Youngho Seo, David M. Wilson   +7 more
wiley   +1 more source

Modified TRACERLab FX_FN module for [¹⁸F]T807 radiosynthesis.

, 2019
Modified TRACERLab FXFN module for [18F]T807 radiosynthesis.
Ling-Wei Hsin (1912123), Chyng-Yann Shiue (823852), Chia-Ling Tsai (3111771), Ming-Jang Chiu (173124), Kuo-Hsing Ma (616060), Ya-Yao Huang (3111768), Chi-Han Wu (6900368), Ruoh-Fang Yen (778232), Hao-Yu Hsieh (6900362), Cheng-Yi Cheng (796895), Ching-Hung Chiu (6900365), Kai-Yuan Tzen (436050)   +11 more
core   +1 more source

Radiosynthesis of [¹⁸F]-Labelled Pro-Nucleotides (ProTides)

Molecules, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success.
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell   +7 more
doaj   +1 more source

One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

EJNMMI Radiopharmacy and Chemistry, 2021
Background Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high accumulation within human tumors ...
Sadahiro Naka, Tadashi Watabe, Thomas Lindner, Jens Cardinale, Kenta Kurimoto, Melissa Moore, Mitsuaki Tatsumi, Yuriko Mori, Eku Shimosegawa, Frank Valla, Hiroki Kato, Frederik L. Giesel   +11 more
doaj   +1 more source

Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

Pharmaceuticals, 2022
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitors ...
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann   +12 more
doaj   +1 more source

Improvement of Radiosynthesis Yield of [11C]acetate [PDF]

, 2018
Purpose [11C] acetate has been proved useful in detecting the myocardial oxygen metabolism and various malignancies including prostate cancer, hepatocellular carcinoma, renal cell carcinoma and brain tumors.
박준영
core  

Synthesis of [¹¹C]BIIB104, an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic-Acid-Positive Allosteric Modulator, and Evaluation of the Bio-Distribution in Non-Human Primate Brains Using Positron Emission Tomography

Molecules
The aim of this study was to measure the brain penetrance and kinetics of BIIB104, a first-in-class AMPA receptor potentiator developed for cognitive impairment associated with schizophrenia.
Sangram Nag, Kevin Jia, Ryosuke Arakawa, Prodip Datta, Daniel Scott, Christopher Shaffer, Mohammad Mahdi Moein, Matthew Hutchison, Maciej Kaliszczak, Christer Halldin   +9 more
doaj   +1 more source

Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2018
Objective(s): Phenytoin is an antiepileptic drug that is used worldwide.The whole-body pharmacokinetics of this drug have been extensivelystudied using 11C-phenytoin in small animals.
Yasukazu Kanai, Yoshinori Miyake, Jun Hatazawa   +2 more
doaj   +1 more source