Results 51 to 60 of about 8,638 (225)

Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole [PDF]

Journal of Radioanalytical and Nuclear Chemistry, 2018
N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research.
Kadirvel, Manikandan, Cardoso, Déborah, Freeman, Sally, Brown, Gavin   +3 more
openaire   +4 more sources

Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer’s disease [PDF]

, 2017
The authentic standards 2-(cyclopropanecarboxamido)-N-(4-methoxypyridin-3-yl)isonicotinamide (4a) and 2-(cyclopropanecarboxamido)-N-(4-(4-methoxyphenyl)pyridin-3-yl)isonicotinamide (7a), and their corresponding precursors 2-(cyclopropanecarboxamido)-N-(4-
Gao, Mingzhang, Wang, Min, Zheng, Qi-Huang   +2 more
core   +2 more sources

Synthesis of carbon-11-labeled CK1 inhibitors as new potential PET radiotracers for imaging of Alzheimer’s disease [PDF]

, 2018
The reference standards methyl 3-((2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)carbamoyl)benzoate (5a) and N-(2,2-difluoro-5H-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-d]imidazol-6-yl)-3-methoxybenzamide (5c), and their corresponding ...
Gao, Mingzhang, Wang, Min, Zheng, Qi-Huang   +2 more
core   +2 more sources

Multicenter Experience with Good Manufacturing Practice Production of [¹¹C]PiB for Amyloid Positron Emission Tomography Imaging

Pharmaceuticals
Alzheimer’s disease (AD) is a neurodegenerative disorder with increasing global prevalence and accounts for over half of all dementia cases. Early diagnosis is paramount for not only the management of the disease, but also for the development of new AD ...
Anders Bruhn Arndal Andersen, Szabolcs Lehel, Ebbe Klit Grove, Niels Langkjaer, Dan Fuglø, Tri Hien Viet Huynh   +5 more
doaj   +1 more source

Radiosynthesis, in vitro and preliminary in vivo evaluation of the novel glutamine derived PET tracers [18F]fluorophenylglutamine and [18F]fluorobiphenylglutamine

, 2020
INTRODUCTION: Glucose has been deemed the driving force of tumor growth for decades. However, research has shown that several tumors metabolically shift towards glutaminolysis.
Baguet, Tristan, Beyzavi, M. Hassan, De Lombaerde, Stef, De Vos, Filip, Descamps, Benedicte, Donche, Sam, Goethals, Ingeborg, Hu, Jiyun, Lambe, Patricia, Pauwelyn, Glenn, Piron, Sarah, Vanhove, Christian, Verhoeven, Jeroen   +12 more
core   +1 more source

Fully automated synthesis of [18F]T807, a PET tau tracer for Alzheimer’s disease [PDF]

, 2015
The authentic standard T807 and its nitro-precursor T807P as well as t-Boc-protected T807P precursor for radiolabeling were synthesized from (4-bromophenyl)boronic acid, 3-bromo-4-nitropyridine and 3-bromo-6-nitropyridine with overall chemical yield 27 ...
Gao, Mingzhang, Wang, Min, Zheng, Qi-Huang   +2 more
core   +1 more source

In Vivo Imaging of the Innate Immune System in the Pancreas in New‐Onset and Long‐Standing Type 1 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Type 1 diabetes (T1D) is an autoimmune disease, but knowledge of immune cell infiltration in the human pancreas is limited due to the risks associated with pancreatic biopsies. This study aimed to evaluate the feasibility of imaging innate immune cells in vivo using positron emission tomography (PET).
Ebrahim Anvari, Hongchao Zhang, Henrik Hill, Nathalia Guarienti Missima, Per Liss, Irina Velikyan, Gunnar Antoni, Olle Korsgren, Daniel Espes, Olof Eriksson   +9 more
wiley   +1 more source

Advancements in Microfluidic Cassette-Based iMiDEV™ Technology for Production of L-[¹¹C]Methionine and [¹¹C]Choline

Pharmaceuticals
Microfluidic technology is a highly efficient technique used in positron emission tomography (PET) radiochemical synthesis. This approach enables the precise control of reactant flows and reaction conditions, leading to improved yields and reduced ...
Hemantha Mallapura, Laurent Tanguy, Samin Mahfuz, Lovisa Bylund, Bengt Långström, Christer Halldin, Sangram Nag   +6 more
doaj   +1 more source

[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model

Molecules, 2018
[18F]FEPPA is a specific ligand for the translocator protein of 18 kDa (TSPO) used as a positron emission tomography (PET) biomarker for glial activation and neuroinflammation.
Nicolas Vignal, Salvatore Cisternino, Nathalie Rizzo-Padoin, Carine San, Fortune Hontonnou, Thibaut Gelé, Xavier Declèves, Laure Sarda-Mantel, Benoît Hosten   +8 more
doaj   +1 more source

Fully automated 18F-fluorination of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) for indirect labelling of nanobodies

Scientific Reports, 2022
N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB), a widely used labeling agent to introduce the 4-[18F]fluorobenzoyl-prosthetic group, is normally obtained in three consecutive steps from [18F]fluoride ion. Here, we describe an efficient one-step labeling
Surasa Nagachinta, Paolo Novelli, Yoann Joyard, Nicolas Maindron, Patrick Riss, Sylvestre Dammicco   +5 more
doaj   +1 more source