Results 51 to 60 of about 6,285 (179)

Optimization of Precursor Preparation in PSMA-11 Radiolabeling to Obtain a Highly Reproducible Radiochemical Yield

Pharmaceuticals, 2022
[68Ga]Ga-PSMA-11 PET/CT plays a pivotal role in the diagnosis and staging of prostate cancer because of its higher sensitivity and detection rate compared with traditional choline PET/CT.
Antonella Iudicello, Stefano Boschi, Pietro Ghedini, Frank Lohr, Stefano Panareo   +4 more
doaj   +1 more source

GMP‐compliant production, validation and dosimetry of clinical grade [18F]3‐(3‐fluoropropyl)‐2‐phenyl‐2,3‐dihydrobenzo[d]thiazole ([18F]FPBT) for oxidative stress PET imaging

British Journal of Pharmacology, Volume 183, Issue 20, Page 6028-6045, October 2026.
Background and Purpose Oxidative stress plays a critical role in the pathophysiology of various diseases, yet current methods for its non‐invasive detection remain limited. This study aimed to systematically validate a superoxide‐selective PET tracer, [18F]FPBT, for the early diagnosis and therapeutic monitoring of oxidative stress‐related conditions ...
Hua Zhang, Fangfang Sun, Chun Li, Xin Wang, Yuexuan Song, Lu Jiang, Paul Gape, Samantha Y. A. Terry, Shujun He, Ran Yan, Zhi Lu   +10 more
wiley   +1 more source

Original one-step radiosynthesis of [¹⁸F]T807(1).

, 2019
Original one-step radiosynthesis of [18F]T807(1).
Ling-Wei Hsin (1912123), Chyng-Yann Shiue (823852), Chia-Ling Tsai (3111771), Ming-Jang Chiu (173124), Kuo-Hsing Ma (616060), Ya-Yao Huang (3111768), Chi-Han Wu (6900368), Ruoh-Fang Yen (778232), Hao-Yu Hsieh (6900362), Cheng-Yi Cheng (796895), Ching-Hung Chiu (6900365), Kai-Yuan Tzen (436050)   +11 more
core   +1 more source

Theranostic π Electron‐Stabilized Polymeric Micelles for PET Imaging‐Guided Drug Delivery to Tumors

Small, Volume 22, Issue 49, 1 September 2026.
Cancer nanomedicine efficacy is limited by heterogeneous nanoparticle accumulation in tumors. Nuclear imaging offers non‐invasive, patient‐ and lesion‐specific visualization and quantification of nanoparticle uptake. We present a positron emission tomography (PET)‐imageable micelle platform for direct quantification of nanoparticle accumulation and ...
Alec Wang, Alexandru Florea, Jan‐Niklas May, Zaheer Ahmed, Karolin Roemhild, Thomas Hansen, Rahaf Mihyar, Armin Azadkhah Shalmani, Laura Schäfer, Karolin Becker, Masoud Sadeghzadeh, Eva M. Buhl, Sven Thoröe‐Boveleth, Susanne Lütje, Agnieszka Morgenroth, Fabian Kiessling, Jochen Maurer, Josbert M. Metselaar, Yang Shi, Felix M. Mottaghy, Quim Peña, Twan Lammers   +21 more
wiley   +1 more source

Radiosynthesis of [^99mTc]BT2 and [^99mTc]MBT2.

, 2016
Radiosynthesis of [99mTc]BT2 and [99mTc]MBT2.
Hiroyuki Watanabe (312793), Masashi Yoshimura (328061), Masafumi Ihara (302200), Masahiro Ono (106488), Shimpei Iikuni (458368), Hatsue Ishibashi-Ueda (781355), Hideo Saji (458369)   +6 more
core   +1 more source

Increased Binding of [18F]Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Parkinson's Disease Brain

Synapse, Volume 80, Issue 5, September 2026.
[18F]Nifene, a PET imaging probe for α4β2* nicotinic acetylcholine receptors, was used to discretely measure changes in hippocampus (HP) and subiculum (SUB) of postmortem Parkinson's disease (PD) cases compared to cognitively normal (CN) cases. Significant increased [18F]nifene binding in PD was observed.
Jogeshwar Mukherjee, Fariha Karim, Allyson Ngo, Christopher Liang, Geidy E. Serrano, Thomas G. Beach   +5 more
wiley   +1 more source

Improved two-step radiosynthesis of [¹⁸F]T807(1).

, 2019
Improved two-step radiosynthesis of [18F]T807(1).
Ling-Wei Hsin (1912123), Chyng-Yann Shiue (823852), Chia-Ling Tsai (3111771), Ming-Jang Chiu (173124), Kuo-Hsing Ma (616060), Ya-Yao Huang (3111768), Chi-Han Wu (6900368), Ruoh-Fang Yen (778232), Hao-Yu Hsieh (6900362), Cheng-Yi Cheng (796895), Ching-Hung Chiu (6900365), Kai-Yuan Tzen (436050)   +11 more
core   +1 more source

Sugar Amino Acid Linkers for the Design of [18F]SiFA‐PSMA Radioligands

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Sugar amino acid (SAA) linkers were incorporated into silicon‐fluoride‐acceptor (SiFA)‐prostate‐specific membrane antigen (PSMA) radioligands to modulate pharmacokinetic properties while preserving efficient 18F isotopic exchange radiolabeling. Furanose‐based SAAs outperformed pyranose analogues, enabling specific tumor visualization by PET despite ...
Narendar R. Gade, Melinda Wuest, Justin J. Bailey, Atul Bhardwaj, Ralf Schirrmacher, Frank Wuest   +5 more
wiley   +1 more source

Phenothiazine structures and radiosynthesis of [¹²⁵I]SIL23.

, 2013
Structures of SIL23 analogues are shown in A. The radiosynthesis of [125I]SIL23 is shown in B.
Zhude Tu (279779), Paul T. Kotzbauer (241155), Lihai Yu (279776), Joel S. Perlmutter (279777), Jinbin Xu (33400), Robert H. Mach (279778), Devika P. Bagchi (279775)   +6 more
core   +1 more source

Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine

Pharmaceuticals, 2023
The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications.
Jason Beaufrez, Stéphane Guillouet, Yann Seimbille, Cécile Perrio   +3 more
doaj   +1 more source