Results 71 to 80 of about 8,638 (225)

Evaluating hepatobiliary transport with 18F-labeled bile acids : the effect of radiolabel position and bile acid structure on radiosynthesis and in vitro and in vivo performance [PDF]

, 2018
Introduction. An in vivo determination of bile acid hepatobiliary transport efficiency can be of use in liver disease and preclinical drug development.
De Lombaerde, Stef, De Vos, Filip, Kersemans, Ken, Neyt, Sara, Vanhove, Christian, Verhoeven, Jeroen   +5 more
core   +3 more sources

Radiosynthesis of 11C-phenytoin Using a DEGDEE Solvent for Clinical PET Studies [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2018
Objective(s): Phenytoin is an antiepileptic drug that is used worldwide.The whole-body pharmacokinetics of this drug have been extensivelystudied using 11C-phenytoin in small animals.
Yasukazu Kanai, Yoshinori Miyake, Jun Hatazawa   +2 more
doaj   +1 more source

Synthesis of [¹¹C]BIIB104, an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic-Acid-Positive Allosteric Modulator, and Evaluation of the Bio-Distribution in Non-Human Primate Brains Using Positron Emission Tomography

Molecules
The aim of this study was to measure the brain penetrance and kinetics of BIIB104, a first-in-class AMPA receptor potentiator developed for cognitive impairment associated with schizophrenia.
Sangram Nag, Kevin Jia, Ryosuke Arakawa, Prodip Datta, Daniel Scott, Christopher Shaffer, Mohammad Mahdi Moein, Matthew Hutchison, Maciej Kaliszczak, Christer Halldin   +9 more
doaj   +1 more source

One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

EJNMMI Radiopharmacy and Chemistry, 2021
Background Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high accumulation within human tumors ...
Sadahiro Naka, Tadashi Watabe, Thomas Lindner, Jens Cardinale, Kenta Kurimoto, Melissa Moore, Mitsuaki Tatsumi, Yuriko Mori, Eku Shimosegawa, Frank Valla, Hiroki Kato, Frederik L. Giesel   +11 more
doaj   +1 more source

Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor [PDF]

, 2017
P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer’s disease. This study reports the first design, synthesis, radiolabeling and biological evaluation
Gao, Mingzhang, Hutchins, Gary D., Meyer, Jill A., Peters, Jonathan S., Territo, Paul R., Wang, Min, Zarrinmayeh, Hamideh, Zheng, Qi-Huang   +7 more
core   +2 more sources

Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine

Pharmaceuticals, 2023
The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications.
Jason Beaufrez, Stéphane Guillouet, Yann Seimbille, Cécile Perrio   +3 more
doaj   +1 more source

Methodological advancements in microfluidic and carbonylation PET radiochemistry [PDF]

, 2016
Along with the progress of PET as a powerful imaging tool in medicine, there has been increasing demand for new labeling methods. The main aim of this PhD dissertation was to develop novel labeling methodologies using the positron emitter carbon-11.
Dahl, Kenneth
core   +1 more source

Radioiodination of Two Carborane‐Based Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
Two dicarbadodecaborane(12)‐based dual cyclooxygenase‐2/5‐lipoxygenase (COX‐2/5‐LO) inhibitors were 123I‐labeled. Refinement of labeling and formulation conditions and extensive in vitro characterization are presented. Cell uptake studies in COX‐2‐ and 5‐LO‐overexpressing cell lines showed COX‐2‐independent and partly 5‐LO‐dependent uptake.
Jonas Schädlich, Martin Ullrich, Cathleen Haase‐Kohn, Robert Wodtke, Sebastian Braun, Maximilian Molitor, Bettina Hofmann, Dieter Steinhilber, Klaus Kopka, Evamarie Hey‐Hawkins, Jens Pietzsch, Markus Laube   +11 more
wiley   +1 more source

Automated One-pot Radiosynthesis of [11C]S-adenosyl Methionine [PDF]

Current Radiopharmaceuticals, 2017
Glycine N-methyltransferase is an enzyme overexpressed in some neoplastic tissues. It catalyses the methylation of glycine using S-adenosyl methionine (SAM or AdoMet) as substrate. SAM is involved in a great variety of biochemical processes, including transmethylation reactions.
Zoppolo, Florencia, Porcal, Williams, Oliver, Patricia, Savio, Eduardo, Engler, Henry   +4 more
openaire   +2 more sources

Olfactory decline tracks central‐to‐peripheral spread of tau pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Olfactory decline often precedes cognitive symptoms in Alzheimer's disease (AD) and is linked to tau pathology. Yet, whether tau aggregates start in peripheral olfactory structures or spread from central regions remains debated. METHODS We analyzed 34 post mortem human olfactory bulb (OB) and 2 neuroepithelium (ONE) samples across
Kamar Bouchoucha, Lisa Collin, Céline Coquette, Lise Colmant, Emilien Boyer, Lara Huyghe, Lisa Quenon, Thomas Gerard, Yasmine Salman, Valérie Hox, Pascal Kienlen‐Campard, Bernard Hanseeuw, Anabelle Decottignies, Caroline Huart   +13 more
wiley   +1 more source