Results 71 to 80 of about 6,098 (221)

Sugar Amino Acid Linkers for the Design of [18F]SiFA‐PSMA Radioligands

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Sugar amino acid (SAA) linkers were incorporated into silicon‐fluoride‐acceptor (SiFA)‐prostate‐specific membrane antigen (PSMA) radioligands to modulate pharmacokinetic properties while preserving efficient 18F isotopic exchange radiolabeling. Furanose‐based SAAs outperformed pyranose analogues, enabling specific tumor visualization by PET despite ...
Narendar R. Gade, Melinda Wuest, Justin J. Bailey, Atul Bhardwaj, Ralf Schirrmacher, Frank Wuest   +5 more
wiley   +1 more source

Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine

Pharmaceuticals, 2023
The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications.
Jason Beaufrez, Stéphane Guillouet, Yann Seimbille, Cécile Perrio   +3 more
doaj   +1 more source

[18F]PSMA‐1007 PET–Based Recurrence Site Distribution and Predictors of Metastatic Disease in Patients With Biochemical Recurrence of Prostate Cancer

International Journal of Urology, Volume 33, Issue 8, August 2026.
ABSTRACT Objectives Prostate‐specific membrane antigen positron emission tomography (PSMA‐PET) is a sensitive imaging modality for detecting recurrent prostate cancer following definitive local therapy. However, evidence on 18F‐labeled PSMA tracers in Japanese patients with biochemical recurrence (BCR) remains limited.
Koji Hatano, Tadashi Watabe, Takero Hirata, Masatoshi Konishi, Tomohiro Kanaki, Masaru Tani, Toshiki Oka, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Kazutoshi Fujita, Motohide Uemura, Frederik L. Giesel, Norio Nonomura   +15 more
wiley   +1 more source

Phenothiazine structures and radiosynthesis of [¹²⁵I]SIL23.

, 2013
Structures of SIL23 analogues are shown in A. The radiosynthesis of [125I]SIL23 is shown in B.
Zhude Tu (279779), Paul T. Kotzbauer (241155), Lihai Yu (279776), Joel S. Perlmutter (279777), Jinbin Xu (33400), Robert H. Mach (279778), Devika P. Bagchi (279775)   +6 more
core   +1 more source

Identification of Pyrazolidine‐3‐One Derivatives as a Novel Structural Scaffold for ATP Synthase Inhibitors

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
Following the discovery of oxadiazin‐5‐ones as partial inhibitors of the ATP synthase, we herein report the synthesis of a library of pyrazolidine‐3‐ones and pyrazol‐3‐ones, designed by reducing the six‐membered N–N heterocycles to five‐membered rings.
Lisa Reichert, Aro Delparente, Ida R. Hipfinger, Lukas Reininger, Ana Pinto Castro, Daniel J. Hubin, Roger Schibli, Amy E. Fraley, Linjing Mu   +8 more
wiley   +1 more source

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION A subset of Alzheimer's disease (AD) patients exhibits a procoagulant state that remains undiagnosed despite available treatments. We developed positron emission tomography (PET) strategies to in vivo detect cerebral microthrombi in TgCRND8 mice. METHODS PET was performed with a fibrin‐binding probe (FBP) in TgCRND8 and wild‐type
Carlos Ceron, Marta Casquero‐Veiga, Nicolás Lamanna‐Rama, Irene Fernández‐Nueda, Alberto Fernández‐Pena, Nancy Olazagoitia, Gorka Sobrino, Aitor Herraiz, María Isabel González, María Muñoz‐Hernando, Alejandro Ruperti‐Repilado, Eduardo Romero‐Sanz, Miguel Ángel Morcillo, Carlos Pérez‐Medina, Maria Angeles Moro, Gonzalo Villaverde, Jorge Rubio, Jose Fernandez‐Ferro, Manuel Desco, Fernando Herranz, Beatriz Salinas, Valentin Fuster, Marta Cortes‐Canteli   +22 more
wiley   +1 more source

Original one-step radiosynthesis of [¹⁸F]T807(1).

, 2019
Original one-step radiosynthesis of [18F]T807(1).
Ling-Wei Hsin (1912123), Chyng-Yann Shiue (823852), Chia-Ling Tsai (3111771), Ming-Jang Chiu (173124), Kuo-Hsing Ma (616060), Ya-Yao Huang (3111768), Chi-Han Wu (6900368), Ruoh-Fang Yen (778232), Hao-Yu Hsieh (6900362), Cheng-Yi Cheng (796895), Ching-Hung Chiu (6900365), Kai-Yuan Tzen (436050)   +11 more
core   +1 more source

Modified TRACERLab FX_FN module for [¹⁸F]T807 radiosynthesis.

, 2019
Modified TRACERLab FXFN module for [18F]T807 radiosynthesis.
Ling-Wei Hsin (1912123), Chyng-Yann Shiue (823852), Chia-Ling Tsai (3111771), Ming-Jang Chiu (173124), Kuo-Hsing Ma (616060), Ya-Yao Huang (3111768), Chi-Han Wu (6900368), Ruoh-Fang Yen (778232), Hao-Yu Hsieh (6900362), Cheng-Yi Cheng (796895), Ching-Hung Chiu (6900365), Kai-Yuan Tzen (436050)   +11 more
core   +1 more source

Automated radiosynthesis of [11C]MTP38—a phosphodiesterase 7 imaging tracer—using [11C]hydrogen cyanide for clinical applications

, 2022
We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3- a]pyrazine-5-[11C]carbonitrile ([11C]MTP38) as a PET tracer for the imaging of phosphodiesterase 7.
1046540, Takehiko, Matsumura, 1046541, 1046542, 1046543, 1046544, 1046545, 1046546, 1046547, 1046548, 1046549, Nobuki, Nengaki, Zhang, Ming-Rong, Ohkubo, Takayuki, Hiroki, Hashimoto, 1046530, 1046531, 1046532, 1046533, 1046534, 1046535, 1046536, 1046537, Hideki, Ishii, 1046538, 1046539, Togashi, Takahiro, Fujishiro, Tomoya, Masanao, Ogawa, Masayuki, Hanyu, 1046525, 1046526, Takeaki, Saijo, 1046527, 1046528, 1046529, Daisuke, Arashi, Kazunori, Kawamura, Masatoshi, Muto, 1046551, 1046552, 1046553, 1046554, 1046555, 1046556, Sakai, Toshiyuki, 1046557, Naoyuki, Obokata, 1046558, Kurihara, Yusuke, Makoto, Takei, 1046550   +51 more
core   +1 more source

Development of a versatile [68Ga]Ga-FAPI-46 automated synthesis suitable to multi-elutions of germanium-68/gallium-68 generators

Frontiers in Chemistry
Gallium-68-labeled FAPI-46 has recently been proposed as a novel positron emission tomography imaging probe to diagnose and monitor a wide variety of cancers.
Louis-Paul Paty, Simon Degueldre, Claire Provost, Claire Provost, Camille Schmitt, Laura Trump, Laura Trump, Julien Fouque, Julien Fouque, Charles Vriamont, Frank Valla, Thibault Gendron, Olivier Madar, Olivier Madar   +13 more
doaj   +1 more source