Results 81 to 90 of about 8,638 (225)
Radiosynthesis of [18F]Trifluoroalkyl Groups: Scope and Limitations [PDF]
BioMed Research International, 2014 The present paper is concerned with radiochemical methodology to furnish the trifluoromethyl motif labelled with18F. Literature spanning the last four decades is comprehensively reviewed and radiochemical yields and specific activities are discussed.
Lien, V. T., Riss, P. J.
openaire +2 more sources
Flow optimization study of a batch microfluidics PET tracer synthesizing device. [PDF]
, 2010 We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers.
Daridon, Antoine +7 more
core +4 more sources
Frontiers in ChemistryGallium-68-labeled FAPI-46 has recently been proposed as a novel positron emission tomography imaging probe to diagnose and monitor a wide variety of cancers.
Louis-Paul Paty +13 more
doaj +1 more source
Improved synthesis of [ 11 C]methylaminobenzovesamicol [PDF]
, 1992 An efficient two‐step synthesis of the potential cholinergic neuronal mapping tracer [ 11 C]methylaminobenzovesamicol (MABV) is described. A tert ‐butoxycarbonyl protecting group was used to activate the aniline nitrogen of aminobenzovesamicol toward ...
Ayyangar +16 more
core +1 more source
Astrocytes and neurons communicate via a monocarboxylic acid shuttle [PDF]
, 2020 Since formulation of the Astrocyte-Neuron Lactate Shuttle (ANLS) hypothesis in 1994, the hypothesis has provoked criticism and debate. Our review does not criticise, but rather integrates experimental data characterizing proton-linked monocarboxylate ...
Cottrell, Graeme S., Roosterman, Dirk
core +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 5, 7 February 2026.This study exploits the comparable binding tolerances between the fluorinase enzyme and the A2A adenosine receptor towards the development of novel C‐2 functionalised 5′‐fluorodeoxy‐adenosine (FDA)‐based agonists with enzymatic 18F‐labelling capability for positron emission tomography (PET).
Nicolas Charalambous +6 more
wiley +1 more source
Synthesis of [11C]MK-1064 as a new PET radioligand for imaging of orexin-2 receptor [PDF]
, 2016 The reference standard MK-1064 {5″-chloro-N-((5,6-dimethoxypyridin-2-yl)methyl)-[2,2′:5′,3″-terpyridine]-3′-carboxamide} was synthesized from methyl 2-chloro-5-iodonicotinate and 5-(chloropyridin-3-yl)boronic acid in 4 steps with 33% overall chemical ...
Gao, Mingzhang +2 more
core +1 more source
A one‐pot radiosynthesis of [18F]PARPi
Journal of Labelled Compounds and Radiopharmaceuticals, 2020 In this paper, we disclose a new strategy for the radiosynthesis of [18F]PARPi from the corresponding, boc‐protected, nitro‐precursor. Using a two‐step procedure, [18F]PARPi could be isolated in radiochemical yields up to 9.6%. The reaction proceeds via an efficient one‐pot, two‐step process, allowing for simplification over previous methods that ...
Thomas C. Wilson +2 more
openaire +3 more sources
Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes
Molecules, 2013 The polymer supported phosphazene bases PS-P2tBu and the novel PS-P2PEG allowed for efficient extraction of [18F]F− from proton irradiated [18O]H2O and subsequent radiofluorination of a broad range of substrates directly on the resin.
Bente Mathiessen, Fedor Zhuravlev
doaj +1 more source
Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI‐2620 PET
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Progressive supranuclear palsy (PSP), a 4‐repeat tauopathy, can be visualized using [18F]PI‐2620 tau positron emission tomography (PET). However, the value of sequential [18F]PI‐2620 imaging for tracking tau accumulation during the disease course has not yet been investigated.
Johannes Gnörich +29 more
wiley +1 more source