Results 101 to 110 of about 6,098 (221)

Adventures in radiosynthesis of clinical grade [⁶⁸Ga]Ga-DOTA-Siglec-9

, 2018
[68Ga]Ga-DOTA-Siglec-9 is the first vascular adhesion protein-1 targeting radiopharmaceutical for positron emission tomography imaging of inflammation, and here we present its long-awaited clinical grade radiosynthesis.
Anne Roivainen, Helena Virtanen, Xiang-Guo Li, Tapio Viljanen, Heidi Liljenbäck, Pauliina Luoto, Sirpa Jalkanen, Meeri Käkelä, Juhani Knuuti   +8 more
core   +1 more source

Procedures for the GMP-Compliant Production and Quality Control of [18F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer

Pharmaceuticals, 2017
Radiolabeled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer.
Jens Cardinale, René Martin, Yvonne Remde, Martin Schäfer, Antje Hienzsch, Sandra Hübner, Anna-Maria Zerges, Heike Marx, Ronny Hesse, Klaus Weber, Rene Smits, Alexander Hoepping, Marco Müller, Oliver C. Neels, Klaus Kopka   +14 more
doaj   +1 more source

Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [18F]FSW-100 for clinical applications

EJNMMI Radiopharmacy and Chemistry
Background Histone deacetylase 6 (HDAC6) is an emerging target for the treatment and diagnosis of proteinopathies. [18F]FSW-100 was recently developed as a promising brain-penetrating radioligand for HDAC6 PET imaging and the process validation of [18F ...
Tetsuro Tago, Jun Toyohara
doaj   +1 more source

Radiosynthesis of ¹⁸F-FP-PEG₂-β-Glu-RGD₂.

, 2015
Radiosynthesis of 18F-FP-PEG2-β-Glu-RGD2.
Hongliang Wang (440441), Caihua Tang (798924), Baoguo Yao (544685), Ganghua Tang (544683), Xiang Liang (363933), Shanzhen He (798925), Kongzhen Hu (544681), Xiaolan Tang (798922), Dahong Nie (798923), Shaobo Yao (544684)   +9 more
core   +1 more source

Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP

EJNMMI Research
Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination.
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas   +9 more
doaj   +1 more source

Criticsal analysis of claims of radiosynthesis by fungi

, 2015
'Radiosynthesis' had been described as the capture and metabolic use of energy from ionizing radiation. Past literature (Dadachova, E., Bryan, R. A., Huang, X., Moadel, T., Schweitzer, A. D., Aisen, P., Nosanchuk, J. D., Casadevall, A. (2007).
Walberg, Eric D.
core  

Radiosynthesis of L-[18F]fluorotryptophan by isotopic exchange on carbonyl-activated precursors [PDF]

, 2015
In the past a variety of 18F-labeled aromatic amino acids have been developed, primarily for tumor diagnostics with positron-emission-tomography.
Weiß, Philipp Sebastian
core   +1 more source

Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel

Scientific Reports
The design and radiosynthesis of [18F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step radiochemical approach that led to the radiosynthesis of [18F]NT376 in a good radiochemical yield, (17.0 ±
Sulan Xu, Chun-Han Huang, Christopher Eyermann, Georgios V. Georgakis, Nashaat Turkman   +4 more
doaj   +1 more source

Preparation of 18F-Labeled Styryl Nitrogenous Heterocycles

Journal of Isotopes, 2018
To synthesize ［18F］Florbetapir, 18F-SPy5, 18F-SPm2 and 18F-SPm5, 18F was labeled by nucleophilic substitution taking p-tosyloxy (OTs) as a leaving group to radiosynthesis ［18F］Florbetapir for represent.
LIU Yinli1;LI Zhongyong1,2
doaj   +1 more source

Iridium-Catalyzed Radiosynthesis of Branched Allylic [¹⁸F]Fluorides

, 2018
The rapid and operationally simple radiosynthesis of branched allylic [18F]­fluorides bearing a variety of functional groups, via iridium-catalyzed nucleophilic substitution reaction utilizing allylic trichloroacetimidates and [18F]­KF·Kryptofix­[2.2.2 ...
Jason C. Mixdorf (4724259), Alexandre M. Sorlin (4724256), David W. Dick (6110573), Hien M. Nguyen (1463050)   +3 more
core   +1 more source