Results 101 to 110 of about 6,285 (179)

GMP compliant simplified fast and high yielding automated synthesis of [18F]fallypride without the need of HPLC purification

EJNMMI Radiopharmacy and Chemistry
Background [18F]Fallypride PET has been used to study D2/3 receptor occupancy and density in neuropsychiatric disorders including Huntington’s disease (HD) and aging in humans.
Ammar Alfteimi, Yi Zhao, Ulf Lützen, Alexander Helm, Michael Jüptner, Maaz Zuhayra   +5 more
doaj   +1 more source

Criticsal analysis of claims of radiosynthesis by fungi

, 2015
'Radiosynthesis' had been described as the capture and metabolic use of energy from ionizing radiation. Past literature (Dadachova, E., Bryan, R. A., Huang, X., Moadel, T., Schweitzer, A. D., Aisen, P., Nosanchuk, J. D., Casadevall, A. (2007).
Walberg, Eric D.
core  

Radiosynthesis and biological evaluation of L- and D-S-(3-[ 18F]fluoropropyl)homocysteine for tumor imaging using positron emission tomography

, 2011
Radiosynthesis and biological evaluation of L- and D-S-(3-[ 18F]fluoropropyl)homocysteine for tumor imaging using positron emission ...
T Jackson (13328955), R Hicks (9869540), R Shepherd (9858140), P Berghofer (13681072), Delphine Denoyer (13066626), C Fookes (13460562), I Greguric (13681099), D Dorow (13704913), M C Gregoire (13681096), T Bourdier (13706701), A Katsifis (13279986)   +10 more
core  

Radiosynthesis of L-[18F]fluorotryptophan by isotopic exchange on carbonyl-activated precursors [PDF]

, 2015
In the past a variety of 18F-labeled aromatic amino acids have been developed, primarily for tumor diagnostics with positron-emission-tomography.
Weiß, Philipp Sebastian
core  

Radiosynthesis and Biological Evaluation of [¹⁸F]Triacoxib: A New Radiotracer for PET Imaging of COX‑2

, 2019
Inducible isozyme cyclooxygenase-2 (COX-2) is upregulated under acute and chronic inflammatory conditions, including cancer, wherein it promotes angiogenesis, tissue invasion, and resistance to apoptosis.
Melinda Wuest, Melinda Wuest (1653253), Marcus Litchfield (8174688), Marcus Litchfield, Frank Wuest (1589737), Darryl Glubrecht, Frank Wuest, Darryl Glubrecht (3438854)   +7 more
core   +1 more source

Automated and manual synthesis of [68Ga]Ga-DOTA-4AH29 intended for PET-imaging of FAP-expression

EJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein is a well-established target for tumour imaging, and single-domain antibodies (sdAb) offer favourable pharmacokinetic properties for PET applications.
Marion Berdal, Surasa Nagachinta, Ximena Langsberg, Vaiva Gaspariunaite, Sam Massa, Ana Rita Pombo Antunes, Dimitrios Mantzilas, Matthias D’Huyvetter, Laurent Navarro   +8 more
doaj   +1 more source

Poly(ADP-ribose) Polymerase in Neurodegeneration: Radiosynthesis and Radioligand Binding in ARC-SWE tg Mice

, 2018
We report the synthesis, radiosynthesis, and characterization of a radioligand for poly­(ADP-ribose) polymerase (PARP). PARP is of central importance in cell homeostasis, neuroplasticity, and neurodegeneration in the brain.
Santosh R. Alluri (4972225), Patrick J. Riss (1547701)   +1 more
core   +1 more source

Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene

EJNMMI Radiopharmacy and Chemistry
Background In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18F]10) prosthetic groups, has paved
Catherine G. F. Dickmann, Andrew D. Bond, Selena Milicevic Sephton, Franklin I. Aigbirhio   +3 more
doaj   +1 more source

Radiosynthesis and Animal Studies of 111In-DTPA-bis-alendronate Complex

Frontiers in Biomedical Technologies, 2015
Purpose- In order to develop new bone imaging agent based on bisphosphonate moiety, an alendronate based complex was designed and prepared in this study.
Ashraf Fakhari, Amir R. Jalilian, Mahdi Shafiee Ardestani, Fariba Johari Deha, Mohammad Mirzaie, Sedigheh Moradkhan, Ali Khalaj   +6 more
doaj  

Reliable One-Pot Automated Preparation of [¹¹C]SL25.1188 for Use in Clinical Imaging Studies. [PDF]

J Labelled Comp Radiopharm
Hashimoto H, Ohkubo T, Tsukagoe K, Fujishiro T, Arashi D, Sato T, Seki T, Kurihara Y, Ogawa M, Muto M, Nengaki N, Mori W, Fujinaga M, Kawamura K, Zhang MR.   +14 more
europepmc   +1 more source