Results 91 to 100 of about 6,285 (179)

Radiosynthesis and Optimization of 18F-Fluorinated GW2580 Derivatives as A Dual Trk/CSF-1R Radiotracer for Potential Use in PET Imaging [PDF]

, 2018
As one of the medical imaging modalities applied in clinical diagnosis of various diseases, positron emission tomography (PET) is used to non-invasively visualize cellular and molecular changes that are occurring in the human body.
Sang Ho Choi
core   +1 more source

Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [18F]FSW-100 for clinical applications

EJNMMI Radiopharmacy and Chemistry
Background Histone deacetylase 6 (HDAC6) is an emerging target for the treatment and diagnosis of proteinopathies. [18F]FSW-100 was recently developed as a promising brain-penetrating radioligand for HDAC6 PET imaging and the process validation of [18F ...
Tetsuro Tago, Jun Toyohara
doaj   +1 more source

Stereoselective radiosynthesis of l- and d-3-[18F]fluoro-α-methyltyrosine

, 2015
A three-step radiosynthesis is described which allows for the first time the preparation of l- and d-3-[18F]fluoro-α-methyltyrosine starting from [18F]fluoride.
Coenen, Heinz H., Humpert, Sven, Ermert, Johannes, Castillo Meleán, Johnny   +3 more
core   +1 more source

Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP

EJNMMI Research
Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination.
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas   +9 more
doaj   +1 more source

An Efficient and Practical Radiosynthesis of [11C] Temozolomide

, 2012
Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [11C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ.
Neelamegam, Ramesh, Hooker, Jacob, Moseley, Christian K., Carlin, Stephen M.   +3 more
core   +1 more source

Iridium-Catalyzed Radiosynthesis of Branched Allylic [¹⁸F]Fluorides

, 2018
The rapid and operationally simple radiosynthesis of branched allylic [18F]­fluorides bearing a variety of functional groups, via iridium-catalyzed nucleophilic substitution reaction utilizing allylic trichloroacetimidates and [18F]­KF·Kryptofix­[2.2.2 ...
Jason C. Mixdorf (4724259), Alexandre M. Sorlin (4724256), David W. Dick (6110573), Hien M. Nguyen (1463050)   +3 more
core   +1 more source

Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel

Scientific Reports
The design and radiosynthesis of [18F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step radiochemical approach that led to the radiosynthesis of [18F]NT376 in a good radiochemical yield, (17.0 ±
Sulan Xu, Chun-Han Huang, Christopher Eyermann, Georgios V. Georgakis, Nashaat Turkman   +4 more
doaj   +1 more source

Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate.

, 2022
Background/Aims: [18F]Fluoroalkyl groups are essential labeling units because they are considered as surrogates for [11C]methyl moieties, and are coupled to the same functional units as the [11C]methyl group.
Wakana, Mori, 1054109, Masanao, Ogawa, 1054106, 1054105, 1054108, 1054107, 1054102, 1054101, 1054104, 1054103, 1054100, Kazunori, Kawamura, Nobuki, Nengaki, Zhang, Ming-Rong, Ohkubo, Takayuki, Hiroki, Hashimoto, 1054112, Masayuki, Fujinaga, 1054098, 1054097, Kurihara, Yusuke, 1054111, 1054099, 1054110, 1054094, 1054093, 1054096, 1054095, Kaito, Tsukagoe   +29 more
core  

Synthesis, Radiosynthesis, and Biological Evaluation of New Proteasome Inhibitors in a Tumor Targeting Approach

, 2016
Proteasome inhibition is a new strategy in cancer therapy. We synthesized three new peptide aldehyde inhibitors linked to the benzamide derivative structure to use their cytotoxic activity against malignant melanoma cells.
Janine Papon (2204626), Jacques Sauzière (2452270), Magali Vivier (2452276), Marie-Josephe Galmier (2435053), Pierre Labarre (2435056), Jean-Claude Madelmont (2204635), Maryse Rapp (2452273)   +6 more
core   +1 more source

[18F]fluoro-benziodoxole : a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

, 2018
Operationally simple radiosynthesis and purification of [F-18]fluoro-benziodoxole was developed starting from a cyclotron produced [F-18]F- precursor, [F-18]TBAF, and tosyl-benziodoxole. The synthetic utility of [F-18]fluoro-benziodoxole was demonstrated
Meyer, Denise N., Gunnar Antoni, Schou, Magnus,, Nordeman, Patrik, Gonzalez, MAC, Miguel A. Cortés González, Bermejo Gómez, Antonio,, Magnus Schou, Antoni, Gunnar,, Cortés González, Miguel A.,, Kálmán J. Szabó, Szabó, Kálmán J.,, Schou, Magnus, Gonzalez, Miguel A. Cortes,, Denise N. Meyer, Antoni, Gunnar, Gonzalez, Miguel A. Cortes, Meyer, DN, Szabo, Kalman J., Gomez, Antonio Bermejo, Nordeman, P, Nordeman, Patrik,, Meyer, Denise N.,, Gomez, AB, Schou, M,, Antoni, G, Antonio Bermejo Gómez, Patrik Nordeman, Szabo, KJ, Gomez, Antonio Bermejo,   +29 more
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