Results 91 to 100 of about 6,098 (221)

In Vivo Imaging of the Innate Immune System in the Pancreas in New‐Onset and Long‐Standing Type 1 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4876-4883, June 2026.
ABSTRACT Objective Type 1 diabetes (T1D) is an autoimmune disease, but knowledge of immune cell infiltration in the human pancreas is limited due to the risks associated with pancreatic biopsies. This study aimed to evaluate the feasibility of imaging innate immune cells in vivo using positron emission tomography (PET).
Ebrahim Anvari, Hongchao Zhang, Henrik Hill, Nathalia Guarienti Missima, Per Liss, Irina Velikyan, Gunnar Antoni, Olle Korsgren, Daniel Espes, Olof Eriksson   +9 more
wiley   +1 more source

Integrating Artificial Intelligence With Droplet‐Based Microfluidics: Advances, Challenges, and Emerging Opportunities

Advanced Intelligent Systems, Volume 8, Issue 5, May 2026.
Droplet‐based microfluidics enables precise, high‐throughput microscale reactions but continues to face challenges in scalability, reproducibility, and data complexity. This review examines how artificial intelligence enhances droplet generation, detection, sorting, and adaptive control and discusses emerging opportunities for clinical and industrial ...
Junyan Lai, Sukrit Gaira, Rongfeng Wang, Qingtian Zhang, Ming Li, Liao Wu, Diangeng Li, Yi Li, Chengchen Zhang, Jinhong Guo, Shi‐Yang Tang   +10 more
wiley   +1 more source

Radiosynthesis of [¹¹C]A-582941 and [¹¹C]A-844606.

, 2013
Radiosynthesis of [11C]A-582941 and [11C]A-844606.
Jin Wu (216487), Muneyuki Sakata (355354), Jun Toyohara (216488), Kenji Hashimoto (36400), Kiichi Ishiwata (354966), Shingo Nishiyama (54233), Hideo Tsukada (54239)   +6 more
core   +1 more source

Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography

Molecules, 2016
Reactive oxygen species (ROS) play important roles in cell signaling and homeostasis. However, an abnormally high level of ROS is toxic, and is implicated in a number of diseases.
Wenjie Zhang, Zhengxin Cai, Lin Li, Jim Ropchan, Keunpoong Lim, Nabil E. Boutagy, Jing Wu, John C. Stendahl, Wenhua Chu, Robert Gropler, Albert J. Sinusas, Chi Liu, Yiyun Huang   +12 more
doaj   +1 more source

Safety of [68Ga]Ga‐FAPI‐46 PET/CT including hemodynamic measurements and patient‐reported outcomes in cancer patients

Clinical Physiology and Functional Imaging, Volume 46, Issue 3, May 2026.
Abstract Introduction Aim Fibroblast activation protein inhibitor (FAPI) has demonstrated promising oncological diagnostic performance. Although no adverse events (AEs) have been previously reported, a formal safety evaluation of FAPI PET/CT is lacking.
Morten Bentestuen, Camilla Sylvest, Svend B. Jensen, Lara R. Soro, Aage Knudsen, Morten Ladekarl, Ole Thorlacius‐Ussing, Wolfgang P. Fendler, Helle D. Zacho   +8 more
wiley   +1 more source

Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated ¹⁸F-trifluoromethylation procedure

, 2018
Automated 18F-trifluoromethylation provided the first radiosynthesis of [18F]Trifluridine, which shows potential as a PET probe of drug mechanism of action.
Chung, Y-L, Chiara Da Pieve, Da Pieve, C, Ciobota, DM, King, A, Turton, D, Gabriela Kramer-Marek, David Turton, Andreas Doepner, Daniela M. Ciobota, Graham Smith, Wong Te Fong, A-C, Kramer-Marek, G, Smith, G, Anne-Christine Wong Te Fong, Yuen-Li Chung, Alice King, Doepner, A   +17 more
core   +1 more source

Development of an automated, GMP compliant FASTlabTM radiosynthesis of [18 F]GE-179 for the clinical study of activated NMDA receptors

, 2020
N-(2-chloro-5-(S-2-[F-18]fluoroethyl)thiophenyl)-N'-(3-thiomethylphenyl)-N'-methylguanidine, ([F-18]GE-179), has been identified as a promising positron emission tomography (PET) ligand for the intra-channel phencyclidine (PCP) binding site of the N ...
Trigg, William, Khan, Imtiaz, McRobbie, Graeme, Brown, Jane, Nairne, James, Black, Andrew, Wilson, Anthony, Berg, Tom Christian, Bhalla, Rajiv, Olsson, Andreas   +9 more
core   +1 more source

Stereoselective radiosynthesis of l- and d-3-[18F]fluoro-α-methyltyrosine

, 2015
A three-step radiosynthesis is described which allows for the first time the preparation of l- and d-3-[18F]fluoro-α-methyltyrosine starting from [18F]fluoride.
Coenen, Heinz H., Humpert, Sven, Ermert, Johannes, Castillo Meleán, Johnny   +3 more
core   +1 more source

Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats

Frontiers in Pharmacology
ObjectiveTo optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent 18F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats.MethodsA more electron-deficient nitropyridine was ...
Yingtong Lu, Yan Cui, Lu Hou, Yuanfang Jiang, Jingjie Shang, Lu Wang, Hao Xu, Weijian Ye, Yang Qiu, Bin Guo   +9 more
doaj   +1 more source

An Efficient and Practical Radiosynthesis of [11C] Temozolomide

, 2012
Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [11C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ.
Neelamegam, Ramesh, Hooker, Jacob, Moseley, Christian K., Carlin, Stephen M.   +3 more
core   +1 more source