Results 41 to 50 of about 774,197 (183)

Automated synthesis of [68Ga]Ga-FAPI-46 without pre-purification of the generator eluate on three common synthesis modules and two generator types

EJNMMI Radiopharmacy and Chemistry, 2022
Background The recent development of quinoline-based radiotracers, which act as fibroblast activation protein inhibitors (FAPIs), has shown promising preclinical and clinical advantages.
Ammar Alfteimi, Ulf Lützen, Alexander Helm, Michael Jüptner, Marlies Marx, Yi Zhao, Maaz Zuhayra   +6 more
doaj   +1 more source

Automated radiosynthesis of [¹⁸F]fluoromannitol on the Sofie Biosciences ELIXYS FLEX/CHEM system. [PDF]

Appl Radiat Isot
Bacterial infections remain a significant global health concern, exacerbated by rising antimicrobial resistance and a growing immunocompromised population. Improved diagnostic tools are essential to accurately detect infections, distinguish them from sterile inflammation, and reduce unnecessary antibiotic use that drives resistance.
Simpson SR, Jouad K, Clay AJ, Ghosh A, Wilde JH, Dickie DA, Vavere AL, Neumann KD.   +7 more
europepmc   +4 more sources

Fully Automated Radiosynthesis of [¹¹C]Guanidines for Cardiac PET Imaging. [PDF]

ACS Med Chem Lett, 2020
Radiolabeled guanidines such as meta-iodobenzylguanidine (MIBG) find utility in nuclear medicine as both diagnostic imaging agents and radiotherapeutics and, over the years, numerous methods for incorporating radionuclides into guanidines have been developed.
Zhao AY, Brooks AF, Raffel DM, Stauff J, Arteaga J, Scott PJH, Shao X.   +6 more
europepmc   +4 more sources

Automated radiosynthesis of [18 F]CETO, a PET radiotracer for imaging adrenal glands, on Synthra RNplus. [PDF]

, 2023
Primary aldosteronism (PA) is the leading secondary cause of hypertension. Determining whether one (unilateral) or both (bilateral) adrenal glands are the source of PA in a patient remains challenging, and yet it is a critical step in the decision ...

core   +2 more sources

Fully-automated synthesis of 177Lu labelled FAPI derivatives on the module modular lab-Eazy

EJNMMI Radiopharmacy and Chemistry, 2021
Background To the best of our knowledge, manually production of [177Lu]Lu-FAPI radiopharmaceutical derivatives has been only described in literature. In this work, a fully-automated [177Lu]Lu-FAPI synthesis has been well designed for the first time using
Kurtulus Eryilmaz, Benan Kilbas
doaj   +1 more source

Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R. Flavell, Michael A. Ohliger, Joanne Engel, Youngho Seo, David M. Wilson   +7 more
wiley   +2 more sources

Automated Synthesis of 18F-AV45 for Aβ-Amyloid Imaging and its Preliminary Clinical Application

Journal of Isotopes, 2021
Aβ-Amyloid positron imaging agent 18F-AV45 was synthesized automatically using TRACERlab FX2 N radiosynthesis module and the clinical imaging of 18F-AV45 was evaluated.
HUANG Zhenghai;REN Chao;ZHU Shikun;WANG Xuezhu;WU Meiqi;HUO Li
doaj   +1 more source

New Fully Automated Preparation of High Apparent Molar Activity ⁶⁸Ga-FAPI-46 on a Trasis AiO Platform

Molecules, 2022
A large number of applications for fibroblast activation protein inhibitors (FAPI)-based PET agents have been evaluated in conditions ranging from cancer to non-malignant diseases such as myocardial infarction. In particular, 68Ga-FAPI-46 was reported to
Chiara Da Pieve, Marta Costa Braga, David R. Turton, Frank A. Valla, Pinar Cakmak, Karl-Heinz Plate, Gabriela Kramer-Marek   +6 more
doaj   +1 more source

An improved automated radiosynthesis of [F-18]FET-beta AG-TOCA [PDF]

, 2018
The fluorine-18 radiolabelled octreotide derivative [18F]FET-βAG-TOCA targeting somatostatin receptor type 2, has been evaluated clinically for positron emission tomography (PET) imaging of neuroendocrine tumours (NETs).
Brickute, Diana, Barnes, Chris, Aboagye, Eric O, Allott, Louis   +3 more
core   +1 more source

Fully Automated Macro- and Microfluidic Production of [⁶⁸Ga]Ga-Citrate on mAIO^® and iMiDEV^TM Modules

Molecules, 2022
68Ga-radionuclide has gained importance due to its availability via 68Ge/68Ga generator or cyclotron production, therefore increasing the number of 68Ga-based PET radiopharmaceuticals available in clinical practice. [68Ga]Ga-citrate PET has been shown to
Olga Ovdiichuk, Emilie Roeder, Sébastien Billotte, Nicolas Veran, Charlotte Collet   +4 more
doaj   +1 more source