Results 21 to 30 of about 774,197 (183)

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

EJNMMI Radiopharmacy and Chemistry
Background (S)-[18F]FETrp is a promising PET radiotracer for imaging IDO1 activity, one of the main enzymes involved in the tryptophan metabolism that plays a key role in several diseases including cancers.
Aurélie Maisonial-Besset, David Kryza, Klaus Kopka, Sophie Levesque, Emmanuel Moreau, Barbara Wenzel, Jean-Michel Chezal   +6 more
doaj   +2 more sources

Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography

Molecules, 2016
Reactive oxygen species (ROS) play important roles in cell signaling and homeostasis. However, an abnormally high level of ROS is toxic, and is implicated in a number of diseases.
Wenjie Zhang, Zhengxin Cai, Lin Li, Jim Ropchan, Keunpoong Lim, Nabil E. Boutagy, Jing Wu, John C. Stendahl, Wenhua Chu, Robert Gropler, Albert J. Sinusas, Chi Liu, Yiyun Huang   +12 more
doaj   +2 more sources

Automated Radiosynthesis and Bio-distribution of ［18F］Fluoromethyl Choline

Journal of Isotopes, 2017
To develop a rapid and automated synthetic method for making ［18F］Fluoromethyl choline （18F-FCH）, the automatic synthesis module from Sumitomo corporation was used to synthesize 18F-FCH, the bio-distribution in normal mice and the PET/CT imaging on ...
LI Yan-peng;WEN Xin;CHENG Bin;XIE Xin-li;DU Xiao-guang;HAN Xing-min
doaj   +2 more sources

A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate

Molecules, 2013
We have developed a new method for automated production of 2-[18F]fluoroethyl tosylate ([18F]FETos) that enables 18F-alkylation to provide PET tracers with high chemical purity.
Gjermund Henriksen, Frode Willoch, János Marton, Bent W. Schoultz, Brian J. Reed   +4 more
doaj   +2 more sources

Increasing the activity output and optimization of automated radiosynthesis [68Ga]Ga-DOTATATE, [68Ga]Ga-Pentixafor, and [68Ga]Ga-FAPI-64 using two [68Ge]Ge/[68Ga]Ga iThemba generators in series [PDF]

EJNMMI Radiopharmacy and Chemistry
Background The rapidly increasing clinical demand for 68Ga-labelled radiopharmaceuticals continues to challenge current production capacities, particularly in high-throughput nuclear medicine departments.
Ammar Alfteimi, Ulf Lützen, Alexander Helm, Michael Jüptner, Yi Zhao, Maaz Zuhayra   +5 more
doaj   +2 more sources

Robust and Facile Automated Radiosynthesis of [¹⁸F]FSPG on the GE FASTlab. [PDF]

Mol Imaging Biol, 2021
Abstract Purpose (S)-4-(3- 18 F-Fluoropropyl)-ʟ-Glutamic Acid ([ 18 F]FSPG) is a radiolabeled non-natural amino acid that is used for positron emission tomography (PET) imaging of the ...
Edwards R, Greenwood HE, McRobbie G, Khan I, Witney TH.   +4 more
europepmc   +4 more sources

Fully Automated, High-Dose Radiosynthesis of [18F]PARPi [PDF]

, 2023
peer reviewed[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the ...
Herrmann, Ken, Fendler, Wolfgang P, Michael Nader, Pacelli, Anna, Warnier, Corentin, Anna Pacelli, Vriamont, Charles, Thibault Gendron, Otabashi, Muhammad, Nader, Michael, Wolfgang P. Fendler, Fadi Zarrad, Alex Jackson, Ken Herrmann, Charles Vriamont, Gendron, Thibault, Zarrad, Fadi, Corentin Warnier, Jackson, Alex, Muhammad Otabashi   +19 more
core   +1 more source

Fully automated radiosynthesis of [¹⁸F]FCPPC for imaging microglia with PET. [PDF]

Am J Nucl Med Mol Imaging
Colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed on microglia in the human brain and thus, has promise as a biomarker for imaging microglia density as a proxy for neuroinflammation. [11C]CPPC is a radiotracer with selective affinity to CSF1R, and has been evaluated for in-human microglia PET imaging.
Roy P, Guo Y, Muzik O, Woodcock EA, Jiang H.   +4 more
europepmc   +3 more sources

Optimized, automated and cGMP-compliant synthesis of the HER2 targeting [68Ga]Ga-ABY-025 tracer

EJNMMI Radiopharmacy and Chemistry, 2023
Background The Affibody molecule, ABY-025, has demonstrated utility to detect human epidermal growth factor receptor 2 (HER2) in vivo, either radiolabelled with indium-111 (111In) or gallium-68 (68Ga).
Emma Jussing, Mélodie Ferrat, Mohammad M. Moein, Henrik Alfredéen, Tetyana Tegnebratt, Klas Bratteby, Erik Samén, Joachim Feldwisch, Renske Altena, Rimma Axelsson, Thuy A. Tran   +10 more
doaj   +1 more source

Improved Automated Radiosynthesis of [11C]PBR28 [PDF]

Scientia Pharmaceutica, 2015
Microglial activation is commonly identified by elevated levels of the 18 kDa translocator protein (TSPO) in response to several inflammatory processes. [(11)C]PBR28 is one of the most promising PET tracers to image TSPO in both human and non-human primates.
SAI, Kiran Kumar SOLINGAPURAM, GAGE, Don, NADER, Mike, MACH, Robert H., MINTZ, Akiva   +4 more
openaire   +2 more sources