Results 11 to 20 of about 774,197 (183)

Fully Automated, High-Dose Radiosynthesis of [¹⁸F]PARPi [PDF]

Pharmaceuticals, 2022
[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications. However, only manual radiosynthesis was reported; this has several drawbacks, including an increased risk of contamination from the operator, and the need to limit ...
Anna Pacelli, Fadi Zarrad, Corentin Warnier, Thibault Gendron, Muhammad Otabashi, Charles Vriamont, Alex Jackson, Wolfgang P. Fendler, Ken Herrmann, Michael Nader   +9 more
doaj   +7 more sources

Automated radiosynthesis of [18F]fluoromannitol for clinical research on a commercially available trasis allinone radiosynthesizer [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Infections pose a significant risk to immunocompromised individuals, and accurate, efficient diagnosis remain challenging. Current imaging methods like MRI and FDG PET lack pathogen specificity which complicate diagnosis and lead to overuse of
Amy L. Vāvere, Allison J. Clay, Arijit Ghosh, Joana Marie Almazan, Melissa J. Brown, Spenser Simpson, Kiel D. Neumann   +6 more
doaj   +7 more sources

An efficient preparation of labelling precursor of [11C]L-deprenyl-D2 and automated radiosynthesis [PDF]

EJNMMI Radiopharmacy and Chemistry, 2017
Background The synthesis of [11C]L-deprenyl-D2 for imaging of astrocytosis with positron emission tomography (PET) in neurodegenerative diseases has been previously reported. [11C]L-deprenyl-D2 radiosynthesis requires a precursor, L-nordeprenyl-D2, which
Kevin Zirbesegger, Pablo Buccino, Ingrid Kreimerman, Henry Engler, Williams Porcal, Eduardo Savio   +5 more
doaj   +4 more sources

Pitfalls and solutions of the fully-automated radiosynthesis of [11C]metoclopramide [PDF]

EJNMMI Radiopharmacy and Chemistry, 2019
Background [11C]Metoclopramide is a new radiotracer for investigating the activity of P-glycoprotein at the blood-brain barrier. A highly stable and reproducible radiosynthesis is a prerequisite for clinical studies applying [11C]metoclopramide or other ...
Verena Pichler, Marius Ozenil, Karsten Bamminger, Chrysoula Vraka, Marcus Hacker, Oliver Langer, Wolfgang Wadsak   +6 more
doaj   +5 more sources

Improved Automated Radiosynthesis of [18F]Dolutegravir: Toward Clinical Applications [PDF]

ACS Omega
Positron emission tomography imaging using radiolabeled dolutegravir (DTG) is an interesting approach to understand the biodistribution of this antiretroviral drug at HIV-1 sanctuary sites. In the course of clinical translation, we depict herein an improved and pharmaceutically compliant radiosynthesis of [18F]DTG from an original tin precursor.
Steve Huvelle, Antoine Pinon, Christine Coulon, Thomas Bonasera, Catherine Chapon, Thibaut Naninck, Roger Le Grand, Chris M. Parry, Bertrand Kuhnast, Fabien Caillé   +9 more
doaj   +4 more sources

A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben [PDF]

EJNMMI Radiopharmacy and Chemistry, 2020
Background Current automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot be economically produced on a ...
Ksenia Lisova, Jia Wang, Philip H. Chao, R. Michael van Dam   +3 more
doaj   +5 more sources

Automated Radiosynthesis of [11C]UCB-J for Imaging Synpatic Density by PET [PDF]

Journal of Labelled Compounds and Radiopharmaceuticals, 2020
An automated radiosynthesis of carbon-11 PET radiotracer [11C]UCB-J for imaging the synaptic density biomarker synaptic vesicle glycoprotein SV2A was established using Synthra RNPlus synthesizer.
Ofer Shamni, Bruno Nebeling, Hilbert Grievink, Eyal Mishani   +3 more
core   +5 more sources

Manual and automated Cu-mediated radiosynthesis of the PARP inhibitor [18F]olaparib [PDF]

Nature Protocols, 2020
Positron emission tomography (PET) is a diagnostic nuclear imaging modality that relies on automated protocols to prepare agents labeled with a positron-emitting radionuclide (e.g., 18F).
Hueting, Rebekka, Rebekka Hueting, Bart Cornelissen, Sean Preshlock, Sap, Jeroen, Guibbal, Florian, Wilson, Thomas C., Thomas C. Wilson, Verhoog, Stefan, Stefan Verhoog, Damien Mahaut, Jeroen B. I. Sap, Taylor, Nichloas J., Véronique Gouverneur, Preshlock, Sean, Pacelli, Anna, Cornelissen, Bart, Patrick G. Isenegger, Anna Pacelli, Nicholas J. Taylor, Mahaut, Damien, Florian Guibbal, Gouverneur, Véronique, Isenegger, Patrick G.   +23 more
core   +3 more sources

Robust and Facile Automated Radiosynthesis of [18F]FSPG on the GE FASTlab [PDF]

, 2020
Purpose: (S)-4-(3-18F-Fluoropropyl)-ʟ-Glutamic Acid ([18F]FSPG) is a radiolabeled non-natural amino acid that is used for positron emission tomography (PET) imaging of the glutamate/cystine antiporter, system xC-, whose expression is upregulated in many ...
Timothy, Witney, Richard, Edwards, Hannah, Greenwood   +2 more
core   +2 more sources

An improved fully-automated GMP radiosynthesis of [18F]fluoro-pivalic acid with solid-phase extraction purification [PDF]

EJNMMI Radiopharmacy and Chemistry
Background We previously reported the first-in-human evaluation of 3-[18F]-fluoro-2,2-dimethylpropionic acid ([18F]FPIA) for imaging aberrant lipid metabolism and cancer detection.
Chris Barnes, Frazer Twyman, Ramla O. Awais, Dylan Pritchard, Matthias Glaser, David R. Turton, Diana Brickute, Graham Smith, Erik Årstad, Louis Allott, Eric O. Aboagye   +10 more
doaj   +5 more sources