Results 31 to 40 of about 774,197 (183)

Automated radiosynthesis of [¹¹C]CPPC for in-human PET imaging applications. [PDF]

Am J Nucl Med Mol Imaging
The macrophage colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed in microglia, representing a biomarker target for imaging of microglia availability. [11C]CPPC has specific binding affinity to CSF1R and suitable kinetic properties for in vivo PET imaging of microglia.
Jiang H, Roy P, Guo Y, Muzik O, Woodcock EA.   +4 more
europepmc   +3 more sources

Synthesis of [18F]FMISO, a hypoxia-specific imaging probe for PET, an overview from a radiochemist’s perspective

EJNMMI Radiopharmacy and Chemistry, 2023
Background [18F]fluoromisonidazole ([18F]FMISO, 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole) is a commonly used radiotracer for imaging hypoxic conditions in cells.
Torsten Kniess, Jörg Zessin, Peter Mäding, Manuela Kuchar, Oliver Kiss, Klaus Kopka   +5 more
doaj   +1 more source

One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

EJNMMI Radiopharmacy and Chemistry, 2021
Background Fibroblast activation protein (FAP) is overexpressed in the stroma of many types of cancer. [18F]AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for FAP, which has already shown high accumulation within human tumors ...
Sadahiro Naka, Tadashi Watabe, Thomas Lindner, Jens Cardinale, Kenta Kurimoto, Melissa Moore, Mitsuaki Tatsumi, Yuriko Mori, Eku Shimosegawa, Frank Valla, Hiroki Kato, Frederik L. Giesel   +11 more
doaj   +1 more source

Automated Radiosynthesis and Micro PET/CT Imaging of 18F-FAPI-42

Journal of Isotopes, 2023
Fibroblast activation protein is highly expressed in most epithelial malignant tumors. FAP inhibitor (FAPI) has been used in the early diagnosis of tumors after radionuclide labeling.
WANG Hua;WANG Meng;HUANG Shun;SUN Penghui;HU Kongzheng;XIANG Xianhong;LIN Weiyuan;ZHI Shengfang;TANG Ganghua;HAN Yanjiang
doaj   +1 more source

Automated radiosynthesis of [18F]CETO, a PET radiotracer for imaging adrenal glands, on Synthra RNplus [PDF]

, 2023
Primary aldosteronism (PA) is the leading secondary cause of hypertension. Determining whether one (unilateral) or both (bilateral) adrenal glands are the source of PA in a patient remains challenging, and yet it is a critical step in the decision ...
Nordeman, Patrik,, Aigbirhio, Franklin I., Gurnell, Mark,, Boros, Istvan, Nordeman, Patrik, Russell, Joseph J.,, Russell, Joseph J., Li Corrigan, Lei,, Aigbirhio, Franklin I.,, Antoni, Gunnar,, Boros, Istvan,, Hird, Matthew,, Gurnell, Mark, Li Corrigan, Lei, Hird, Matthew, Antoni, Gunnar   +15 more
core   +4 more sources

Automated Radiosynthesis, Quality Control, and Biodistribution of Ga-68 Pentixafor: First Indian Experience. [PDF]

Indian J Nucl Med, 2021
Background: Chemokine receptor CXCR4 is overexpressed in more than 27 different human tumors that make it a promising target in oncology. Ga-68 Pentixafor is the most promising positron emission tomography tracer for imaging CXCR4 receptors; hence, the present study was carried out to optimize the radiosynthesis
Watts A, Chutani S, Arora D, Madivanane V, Thakur S, Kamboj M, Singh B.   +6 more
europepmc   +4 more sources

Copper-Mediated Radiofluorination of the Excitatory Amino Acid Transporter 2 (EAAT2)-Targeted PET Tracer [¹⁸F]RP-115: Alternate Synthetic Method. [PDF]

J Labelled Comp Radiopharm
An efficient two‐step radiosynthesis of [18F]RP‐115 was developed using copper‐mediated radiofluorination (CMRF) followed by deprotection. In a total 70‐min synthesis time, this approach provided [18F]RP‐115 in high radiochemical yield (52.8% ± 2.1%, decay corrected from stating [18F]fluoride ion) with high molar activity (355 ± 61 GBq/μmol) and ...
Lee SH, Blecha J, Kim JM, Nillo RM, Flavell RR, Chao CK, Forsayeth JR, Gerdes JM, VanBrocklin HF, Wilson DM.   +9 more
europepmc   +2 more sources

Automation of the Radiosynthesis of Six Different 18F-labeled radiotracers on the AllinOne [PDF]

EJNMMI Radiopharmacy and Chemistry, 2016
Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these six 18F-labeled radiopharmaceuticals produced on a routine basis ...
Shihong Li, Alexander Schmitz, Hsiaoju Lee, Robert H. Mach   +3 more
openaire   +3 more sources

Automated One-pot Radiosynthesis of [11C]S-adenosyl Methionine [PDF]

Current Radiopharmaceuticals, 2017
Glycine N-methyltransferase is an enzyme overexpressed in some neoplastic tissues. It catalyses the methylation of glycine using S-adenosyl methionine (SAM or AdoMet) as substrate. SAM is involved in a great variety of biochemical processes, including transmethylation reactions.
Zoppolo, Florencia, Porcal, Williams, Oliver, Patricia, Savio, Eduardo, Engler, Henry   +4 more
openaire   +2 more sources

Automated microfluidic chip system for radiosynthesis of PET imaging probes [PDF]

Journal of Zhejiang University-SCIENCE B, 2019
Positron emission tomography (PET) is a powerful non-invasive molecular imaging technique for the early detection, characterization, and "real-time" monitoring of disease, and for investigating the efficacy of drugs (Phelps, 2000; Ametamey et al., 2008).
Ming Lei, Jian-zhang Pan, Guang-ming Xu, Pei-zhen Du, Mei Tian, Hong Zhang   +5 more
openaire   +2 more sources