Results 51 to 60 of about 774,197 (183)

A comparison of labelling characteristics of manual and automated synthesis methods for gallium-68 labelled ubiquicidin [PDF]

, 2021
Gallium-68 labelled 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) is currently investigated as a PET radiopharmaceutical for the imaging of infections.
Ebenhan, Thomas, Rubow, Sietske, Le Roux, Jannie   +2 more
core   +1 more source

Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated ¹⁸F-trifluoromethylation procedure

, 2018
Automated 18F-trifluoromethylation provided the first radiosynthesis of [18F]Trifluridine, which shows potential as a PET probe of drug mechanism of action.
Chung, Y-L, Chiara Da Pieve, Da Pieve, C, Ciobota, DM, King, A, Turton, D, Gabriela Kramer-Marek, David Turton, Andreas Doepner, Daniela M. Ciobota, Graham Smith, Wong Te Fong, A-C, Kramer-Marek, G, Smith, G, Anne-Christine Wong Te Fong, Yuen-Li Chung, Alice King, Doepner, A   +17 more
core   +1 more source

Automated Solid-Phase Radiofluorination Using Polymer-Supported Phosphazenes

Molecules, 2013
The polymer supported phosphazene bases PS-P2tBu and the novel PS-P2PEG allowed for efficient extraction of [18F]F− from proton irradiated [18O]H2O and subsequent radiofluorination of a broad range of substrates directly on the resin.
Bente Mathiessen, Fedor Zhuravlev
doaj   +1 more source

Fully automated 18F-fluorination of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) for indirect labelling of nanobodies

Scientific Reports, 2022
N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB), a widely used labeling agent to introduce the 4-[18F]fluorobenzoyl-prosthetic group, is normally obtained in three consecutive steps from [18F]fluoride ion. Here, we describe an efficient one-step labeling
Surasa Nagachinta, Paolo Novelli, Yoann Joyard, Nicolas Maindron, Patrick Riss, Sylvestre Dammicco   +5 more
doaj   +1 more source

Design and Synthesis of an 18F-Labeled Version of Phenylethyl Orvinol ([18F]FE-PEO) for PET-Imaging of Opioid Receptors

Molecules, 2012
The semisynthetic oripavine derivative phenethyl orvinol (PEO), a full agonist at opioid receptors (OR), is an attractive structural motif for developing 18F-labeled PET tracers with a high degree of sensitivity for competition between endogenous and ...
Gjermund Henriksen, János Marton
doaj   +1 more source

Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor. [PDF]

PLoS ONE, 2017
New radiochemistry techniques can yield novel PET tracers for COX-2 and address the shortcomings in in vivo stability and specificity, which have held back clinical translation of tracers to image COX-2 expression. Current techniques limit radiosynthesis
Artem Lebedev, Jing Jiao, Jason Lee, Fan Yang, Nathanael Allison, Harvey Herschman, Saman Sadeghi   +6 more
doaj   +1 more source

Automated radiosynthesis of [¹⁸F]DPA-714 on a commercially available IBA Synthera®. [PDF]

Appl Radiat Isot, 2023
The goal of this work was to develop a reliable method to produce the well-validated microglial activation PET tracer, [18F]DPA-714, routinely for clinical and preclinical research using an IBA Synthera®. Optimization of literature methods included reduced precursor mass and use of TBA HCO3 as the phase transfer agent in place of Kryptofix® 222 in a 65-
Vāvere AL, Ghosh A, Amador Diaz V, Clay AJ, Hall PM, Neumann KD.   +5 more
europepmc   +3 more sources

Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain

Pharmaceuticals, 2022
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitors ...
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann   +12 more
doaj   +1 more source

Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP

EJNMMI Research
Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination.
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas   +9 more
doaj   +1 more source

Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine

Pharmaceuticals, 2023
The development of 18F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications.
Jason Beaufrez, Stéphane Guillouet, Yann Seimbille, Cécile Perrio   +3 more
doaj   +1 more source