Results 61 to 70 of about 774,197 (183)

GMP‐compliant production, validation and dosimetry of clinical grade [18F]3‐(3‐fluoropropyl)‐2‐phenyl‐2,3‐dihydrobenzo[d]thiazole ([18F]FPBT) for oxidative stress PET imaging

British Journal of Pharmacology, Volume 183, Issue 20, Page 6028-6045, October 2026.
Background and Purpose Oxidative stress plays a critical role in the pathophysiology of various diseases, yet current methods for its non‐invasive detection remain limited. This study aimed to systematically validate a superoxide‐selective PET tracer, [18F]FPBT, for the early diagnosis and therapeutic monitoring of oxidative stress‐related conditions ...
Hua Zhang, Fangfang Sun, Chun Li, Xin Wang, Yuexuan Song, Lu Jiang, Paul Gape, Samantha Y. A. Terry, Shujun He, Ran Yan, Zhi Lu   +10 more
wiley   +1 more source

Improvement of Radiosynthesis Yield of [11C]acetate [PDF]

, 2018
Purpose [11C] acetate has been proved useful in detecting the myocardial oxygen metabolism and various malignancies including prostate cancer, hepatocellular carcinoma, renal cell carcinoma and brain tumors.
박준영
core  

Automated radiosynthesis of 18F-fluoromethylated tracers using the simplified one-pot 18F-fluoromethylation via [18F]fluoromethyl tosylate.

, 2022
Background/Aims: [18F]Fluoroalkyl groups are essential labeling units because they are considered as surrogates for [11C]methyl moieties, and are coupled to the same functional units as the [11C]methyl group.
Wakana, Mori, 1054109, Masanao, Ogawa, 1054106, 1054105, 1054108, 1054107, 1054102, 1054101, 1054104, 1054103, 1054100, Kazunori, Kawamura, Nobuki, Nengaki, Zhang, Ming-Rong, Ohkubo, Takayuki, Hiroki, Hashimoto, 1054112, Masayuki, Fujinaga, 1054098, 1054097, Kurihara, Yusuke, 1054111, 1054099, 1054110, 1054094, 1054093, 1054096, 1054095, Kaito, Tsukagoe   +29 more
core  

Sulfur [¹⁸F]Fluoride Exchange Reaction Enables Rapid Access to ¹⁸F-Labeled PET Tracers

Medical Sciences Forum, 2022
Efficient 18F-fluorination procedures for the production of radiopharmaceuticals are urgently needed to satisfy the increasing demand for clinical diagnostics using positron emission tomography (PET).
Austin Craig, Jürgen Kogler, Fabian Krutzek, Florian Brandt, Markus Laube, Martin Ullrich, Cornelius Kurt Donat, Klaus Kopka, Sven Stadlbauer   +8 more
doaj   +1 more source

Increased Binding of [18F]Nifene, a PET Imaging Probe for α4β2* Nicotinic Acetylcholinergic Receptors in Hippocampus–Subiculum of Postmortem Human Parkinson's Disease Brain

Synapse, Volume 80, Issue 5, September 2026.
[18F]Nifene, a PET imaging probe for α4β2* nicotinic acetylcholine receptors, was used to discretely measure changes in hippocampus (HP) and subiculum (SUB) of postmortem Parkinson's disease (PD) cases compared to cognitively normal (CN) cases. Significant increased [18F]nifene binding in PD was observed.
Jogeshwar Mukherjee, Fariha Karim, Allyson Ngo, Christopher Liang, Geidy E. Serrano, Thomas G. Beach   +5 more
wiley   +1 more source

Sugar Amino Acid Linkers for the Design of [18F]SiFA‐PSMA Radioligands

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Sugar amino acid (SAA) linkers were incorporated into silicon‐fluoride‐acceptor (SiFA)‐prostate‐specific membrane antigen (PSMA) radioligands to modulate pharmacokinetic properties while preserving efficient 18F isotopic exchange radiolabeling. Furanose‐based SAAs outperformed pyranose analogues, enabling specific tumor visualization by PET despite ...
Narendar R. Gade, Melinda Wuest, Justin J. Bailey, Atul Bhardwaj, Ralf Schirrmacher, Frank Wuest   +5 more
wiley   +1 more source

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +2 more sources

Efficient one-pot radiosynthesis of the 11C-labeled aquaporin-4 inhibitor TGN-020

EJNMMI Radiopharmacy and Chemistry
Background [11C]TGN-020 has been developed as a positron emission tomography (PET) tracer for imaging aquaporin-4 (AQP4) in the brain and used in clinical studies.
Kazunori Kawamura, Katsushi Kumata, Tomoteru Yamasaki, Masanao Ogawa, Yusuke Kurihara, Nobuki Nengaki, Yukimi Nakamura, Maiko Ono, Yuhei Takado, Hironaka Igarashi, Ming-Rong Zhang   +10 more
doaj   +1 more source

Biodistribution and Dosimetry Evaluation for a Novel Tau Tracer [18F]-S16 in Healthy Volunteers and Its Application in Assessment of Tau Pathology in Alzheimer’s Disease

Frontiers in Bioengineering and Biotechnology, 2022
Background: The goal of this study was to report a fully automated radiosynthetic procedure of a novel tau tracer [18F]-S16 and its safety, biodistribution, and dosimetry in healthy volunteers as well as the potential utility of [18F]-S16 positron ...
Ying Wang, Li Cai, Kaixiang Zhou, Mengchao Cui, Shaobo Yao, Shaobo Yao   +5 more
doaj   +1 more source

[18F]PSMA‐1007 PET–Based Recurrence Site Distribution and Predictors of Metastatic Disease in Patients With Biochemical Recurrence of Prostate Cancer

International Journal of Urology, Volume 33, Issue 8, August 2026.
ABSTRACT Objectives Prostate‐specific membrane antigen positron emission tomography (PSMA‐PET) is a sensitive imaging modality for detecting recurrent prostate cancer following definitive local therapy. However, evidence on 18F‐labeled PSMA tracers in Japanese patients with biochemical recurrence (BCR) remains limited.
Koji Hatano, Tadashi Watabe, Takero Hirata, Masatoshi Konishi, Tomohiro Kanaki, Masaru Tani, Toshiki Oka, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Kazutoshi Fujita, Motohide Uemura, Frederik L. Giesel, Norio Nonomura   +15 more
wiley   +1 more source