Results 71 to 80 of about 774,197 (183)

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION A subset of Alzheimer's disease (AD) patients exhibits a procoagulant state that remains undiagnosed despite available treatments. We developed positron emission tomography (PET) strategies to in vivo detect cerebral microthrombi in TgCRND8 mice. METHODS PET was performed with a fibrin‐binding probe (FBP) in TgCRND8 and wild‐type
Carlos Ceron, Marta Casquero‐Veiga, Nicolás Lamanna‐Rama, Irene Fernández‐Nueda, Alberto Fernández‐Pena, Nancy Olazagoitia, Gorka Sobrino, Aitor Herraiz, María Isabel González, María Muñoz‐Hernando, Alejandro Ruperti‐Repilado, Eduardo Romero‐Sanz, Miguel Ángel Morcillo, Carlos Pérez‐Medina, Maria Angeles Moro, Gonzalo Villaverde, Jorge Rubio, Jose Fernandez‐Ferro, Manuel Desco, Fernando Herranz, Beatriz Salinas, Valentin Fuster, Marta Cortes‐Canteli   +22 more
wiley   +1 more source

Automated radiosynthesis of the adenosine A_2A receptor‐targeting radiotracer [¹⁸F]FLUDA

Journal of Labelled Compounds and Radiopharmaceuticals, 2022
[18F]FLUDA is a selective radiotracer for in vivo imaging of the adenosine A2A receptor (A2AR) by positron emission tomography (PET). Promising preclinical results obtained by neuroimaging of mice and piglets suggest the translation of [18F]FLUDA to human PET studies.
Lai, T. H., Wenzel, B., Moldovan, R.-P., Brust, P., Kopka, K., Teodoro, R.   +5 more
openaire   +3 more sources

Development and characterization of a novel TDP‐43 positron emission tomography tracer: [18F]JNJ‐TDP43‐1

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), limbic‐predominant age‐related TDP‐43 encephalopathy (LATE), and Alzheimer's disease (AD) are associated with TAR DNA‐binding protein 43 (TDP‐43) pathology.
Chunfang A. Xia, Mani Salarian, Christopher J. Gartshore, Antonella Scaglione, Thomas Hayes, Shuanglong Liu, Hsiu‐Ming Tsai, Javier Echavarren, Jose Maria Cid, Alessandra Matzeu, A. Katrin Szardenings   +10 more
wiley   +1 more source

Fully Automated Production of (((S)-1-Carboxy-5-(6-([¹⁸F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-l-glutamic Acid ([¹⁸F]JK-PSMA-7)

Pharmaceuticals
Background: The radiotracer [18F]JK-PSMA-7, a prostate cancer imaging agent for positron emission tomography (PET), was previously synthesized by indirect radiofluorination using an 18F-labeled active ester as a prosthetic group, which had to be isolated
Philipp Krapf, Thomas Wicher, Boris D. Zlatopolskiy, Johannes Ermert, Bernd Neumaier   +4 more
doaj   +1 more source

Automated radiosynthesis of 5-[¹¹C]l-glutamine, an important tracer for glutamine utilization. [PDF]

Nucl Med Biol, 2018
The natural amino acid l-Glutamine (Gln) is essential for both cell growth and proliferation. In addition to glucose, cancer cells utilize Gln as a carbon source for ATP production, biosynthesis, and as a defense against reactive oxygen species. The utilization of [11C]Gln has been previously reported as a biomarker for tissues with an elevated demand ...
Rosenberg AJ, Nickels ML, Schulte ML, Manning HC.   +3 more
europepmc   +4 more sources

Integrating Artificial Intelligence With Droplet‐Based Microfluidics: Advances, Challenges, and Emerging Opportunities

Advanced Intelligent Systems, Volume 8, Issue 5, May 2026.
Droplet‐based microfluidics enables precise, high‐throughput microscale reactions but continues to face challenges in scalability, reproducibility, and data complexity. This review examines how artificial intelligence enhances droplet generation, detection, sorting, and adaptive control and discusses emerging opportunities for clinical and industrial ...
Junyan Lai, Sukrit Gaira, Rongfeng Wang, Qingtian Zhang, Ming Li, Liao Wu, Diangeng Li, Yi Li, Chengchen Zhang, Jinhong Guo, Shi‐Yang Tang   +10 more
wiley   +1 more source

Radiosynthesis of racemic and enantiomerically pure (−)-[18F]flubatine—A promising PET radiotracer for neuroimaging of α4β2 nicotinic acetylcholine receptors

, 2013
(−)-[18F]flubatine is a promising agent for visualization by PET of cerebral α4β2 nicotinic acetylcholine receptors (nAChRs), which are implicated in psychiatric and neurodegenerative disorders.
Fischer, Steffen, Smits, René, Wenzel, Barbara, Funke, Uta, Steinbach, Jörg, Hiller, Achim, Sabri, Osama, Brust, Peter, Hoepping, Alexander, Cumming, Paul   +9 more
core   +1 more source

Safety of [68Ga]Ga‐FAPI‐46 PET/CT including hemodynamic measurements and patient‐reported outcomes in cancer patients

Clinical Physiology and Functional Imaging, Volume 46, Issue 3, May 2026.
Abstract Introduction Aim Fibroblast activation protein inhibitor (FAPI) has demonstrated promising oncological diagnostic performance. Although no adverse events (AEs) have been previously reported, a formal safety evaluation of FAPI PET/CT is lacking.
Morten Bentestuen, Camilla Sylvest, Svend B. Jensen, Lara R. Soro, Aage Knudsen, Morten Ladekarl, Ole Thorlacius‐Ussing, Wolfgang P. Fendler, Helle D. Zacho   +8 more
wiley   +1 more source

Olfactory decline tracks central‐to‐peripheral spread of tau pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Olfactory decline often precedes cognitive symptoms in Alzheimer's disease (AD) and is linked to tau pathology. Yet, whether tau aggregates start in peripheral olfactory structures or spread from central regions remains debated. METHODS We analyzed 34 post mortem human olfactory bulb (OB) and 2 neuroepithelium (ONE) samples across
Kamar Bouchoucha, Lisa Collin, Céline Coquette, Lise Colmant, Emilien Boyer, Lara Huyghe, Lisa Quenon, Thomas Gerard, Yasmine Salman, Valérie Hox, Pascal Kienlen‐Campard, Bernard Hanseeuw, Anabelle Decottignies, Caroline Huart   +13 more
wiley   +1 more source

[¹⁸F]AB5186 radiosynthesis.

, 2019
[18F]AB5186 radiosynthesis.
Gillian A. Gray (6786209), Sally L. Pimlott (1366506), Christophe Lucatelli (3033765), Lewis Williams (5811791), Mark G. MacAskill (6786194), David E. Newby (411328), Andrew Sutherland (1298325), Timaeus E. F. Morgan (6786200), Carlos José Alcaide-Corral (6786203), Adriana A. S. Tavares (6786212), Tashfeen Walton (6786197), Marc R. Dweck (6786206)   +11 more
core   +1 more source