Results 81 to 90 of about 774,197 (183)

Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene

EJNMMI Radiopharmacy and Chemistry
Background In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18F]10) prosthetic groups, has paved
Catherine G. F. Dickmann, Andrew D. Bond, Selena Milicevic Sephton, Franklin I. Aigbirhio   +3 more
doaj   +1 more source

25 Years of “Loop” Radiochemistry for PET Imaging

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 4-6, April‐May 2026.
While conventional methods to 11C‐ and 18F‐labelled radiopharmaceuticals utilize a vial‐based approach, in the past quarter‐century, a modern, efficient, and cleaner “loop method” has been developed. The radiochemical diversity of reactions synthesized by the loop method are shown.
Emily Murrell, Sahil Khan, Neil Vasdev
wiley   +1 more source

Fluorinated Carnitine Derivatives as Tools to Visualise Carnitine Transport and Metabolism

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Fluorinated carnitines, fluoromethyl carnitine (FMC) and [18F]fluoromethyl carnitine ([18F]FMC), are synthesised and established as powerful probes to interrogate carnitine biology. The multimodal detection facilitated by fluorine labelling, including 19F NMR, mass spectrometry, and positron emission tomography imaging, allowed for visualisation of ...
Richard S. Edwards, Ella‐May Hards, Sofia N. dos Santos, Hannah E. Greenwood, Madeleine E. George, Andrea Emanuelli, Muhammet Tanc, Thomas R. Eykyn, Timothy H. Witney   +8 more
wiley   +1 more source

Automated light-induced synthesis of 89Zr-radiolabeled antibodies for immuno-positron emission tomography

Scientific Reports, 2022
Clinical production of 89Zr-radiolabeled antibodies (89Zr-mAbs) for positron emission tomography imaging relies on the pre-conjugation of desferrioxamine B (DFO) to the purified protein, followed by isolation and characterization of the functionalized ...
Simon Klingler, Jason P. Holland
doaj   +1 more source

Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI‐2620 PET

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Progressive supranuclear palsy (PSP), a 4‐repeat tauopathy, can be visualized using [18F]PI‐2620 tau positron emission tomography (PET). However, the value of sequential [18F]PI‐2620 imaging for tracking tau accumulation during the disease course has not yet been investigated.
Johannes Gnörich, Julia Kusche‐Palenga, Carla Palleis, Antonia Neubauer, Lukas Frontzkowski, Alexander Jäck, Agnes Kling, Theresa Bauer, Hannah Eyob, Katharina Probst, Sebastian N. Roemer‐Cassiano, Alexander M. Bernhardt, Sabrina Katzdobler, Lena Marth, Mirlind Zaganjori, Franziska Hopfner, Andreas Zwergal, Jan Häckert, Michael Rullmann, Osama Sabri, Henryk Barthel, Sophia Stöcklein, Rudolf A. Werner, Mikael Simons, Johannes Levin, Jochen Herms, Nicolai Franzmeier, Günter U. Höglinger, Matthias Brendel, for the German Imaging Initiative for Tauopathies (GII4T)   +29 more
wiley   +1 more source

Synthesis and Application of [18F]Togni Reagent I: An Electrophilic 18F‐Labeled Trifluoromethylating Reagent for Positron Emission Tomography Tracer Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 4, January 26, 2026.
Togni reagent I, one of the most used electrophilic trifluoromethylating reagents, has been radiolabeled with fluorine‐18 starting from the widely available fluoro‐benziodoxole and the [18F]Ruppert–Prakash reagent. To demonstrate the broad potential for late‐stage functionalization, aliphatic carboxylic acids were successfully converted into their 18F ...
Lizeth Y. F. Haveman, Albert D. Windhorst, Danielle J. Vugts   +2 more
wiley   +1 more source

Automated Synthesis of 5-HT1A Receptors Antagonists 11C-WAY-100635

Journal of Isotopes, 2017
A fully automated synthesis of 11C-labeled-N-［2-［4-(2-methoxyphenyl)-1-piperazinyl］ethyl］-N-2-pyridinylcyclohexanecarboxamide maleate (11C-WAY-100635) for imaging 5-HT1A receptors was performed on a module system.
LI Hui-qiang1,2;ZHEN Zhi-fei1;ZHANG Wei-feng1;LIAO Shu-guang1;LI Hong-li3;XU Jun-ling1,2
doaj   +1 more source

Fully-automated radiosynthesis of the amyloid tracer [11C] PiB via direct [11C]CO2 fixation-reduction

EJNMMI Radiopharmacy and Chemistry, 2019
Background The β-amyloid radiotracer [11C] PiB is extensively used for the Positron Emission Tomography (PET) diagnosis of Alzheimer’s Disease and related dementias.
Pablo Buccino, Eduardo Savio, Williams Porcal   +2 more
doaj   +1 more source

Liquid Chromatography‐Tandem Mass Spectrometry Methods for Rapid Measurement of the Molar Activity (Am) of Cyclotron‐Produced [18F]Fluoride and Derived Radiotracers

Chemistry–Methods, Volume 6, Issue 1, January 2026.
Accurate and simple liquid chromatography‐tandem mass spectrometry methods for measuring Am for [18F]fluoride on two rapidly derived surrogates, [18F]FAY and [18F]PCBSF, can serve as forensic tools for investigating the sources of carrier, Am determinations during routine tracer productions and be applied to radiotracers lacking a strong ultraviolet ...
Nicholas R. Ellin, Sean W. Costner, Cheryl L. Morse, Fatemak Ahmadi, Sanjay Telu, Fabrice G. Siméon, Shuiyu Lu, H. Umesha Shetty, Victor W. Pike   +8 more
wiley   +1 more source

Procedures for the GMP-Compliant Production and Quality Control of [18F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer

Pharmaceuticals, 2017
Radiolabeled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer.
Jens Cardinale, René Martin, Yvonne Remde, Martin Schäfer, Antje Hienzsch, Sandra Hübner, Anna-Maria Zerges, Heike Marx, Ronny Hesse, Klaus Weber, Rene Smits, Alexander Hoepping, Marco Müller, Oliver C. Neels, Klaus Kopka   +14 more
doaj   +1 more source