Results 181 to 190 of about 7,738 (197)

Automated Radiosynthesis of [18F]FluoFAPI and Its Dosimetry and Single Acute Dose Toxicological Evaluation

Jason A. Witek, Allen F. Brooks, Sahil M. Kapila, Wade P. Winton, Jenelle Stauff, Peter J. H. Scott, Benjamin L. Viglianti   +6 more
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One-Step Synthesis of [¹⁸F]Aromatic Electrophile Prosthetic Groups via Organic Photoredox Catalysis. [PDF]

ACS Cent Sci
Li M, Staton C, Ma X, Zhao W, Pan L, Giglio B, Berton HS, Wu Z, Nicewicz DA, Li Z.   +9 more
europepmc   +1 more source

Development of a Novel HIF-2α PET Tracer for Noninvasive Tumor Hypoxia Imaging. [PDF]

ACS Omega
Wang Y, Wang Y, Bai P, Cui J, Zhou Y, Li H, Wu L, Wang H, Bai S, Ya R, Bai X, Liu Z, Liu T.   +12 more
europepmc   +1 more source

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PET Imaging of P2X7 Receptor (P2X7R) for Neuroinflammation with Improved Radiosynthesis of Tracer [18F]4A in Mice and Non-human Primates.

ACS Chemical Neuroscience, 2022
The P2X7 receptor (P2X7R) is a key neuroinflammation target in a variety of neurodegenerative diseases. Improved radiosynthesis was developed according to the previously reported P2X7R antagonist GSK1482160.
Guolong Huang, Yifan Qiu, Lei Bi, Huiyi Wei, Guocong Li, Zhijun Li, Peizhen Ye, Min Yang, Yanfang Shen, H. Liu, Lu Wang, Hongjun Jin   +11 more
semanticscholar   +1 more source

Recent advances in microfluidic devices for radiosynthesis of PET-imaging probes.

Chemistry - An Asian Journal, 2022
In order to accommodate the growing demand for positron emission tomography (PET), it will be necessary to create innovative radiochemical and engineering technologies to optimize the manufacture and development of PET probes.
H. Elkawad, Yangyang Xu, M. Tian, Chenyang Jin, H. Zhang, Kaiwu Yu, Qinggang He   +6 more
semanticscholar   +1 more source

Automated radiosynthesis of [11 C]MTP38-a phosphodiesterase 7 imaging tracer-using [11 C]hydrogen cyanide for clinical applications.

Journal of labelled compounds & radiopharmaceuticals, 2022
We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-[11 C]carbonitrile ([11 C]MTP38) as a PET tracer for the imaging of phosphodiesterase 7. For the fully automated production of [11 C]MTP38 routinely and efficiently
K. Kawamura, Hiroki Hashimoto, Takayuki Ohkubo, Masayuki Hanyu, M. Ogawa, N. Nengaki, Daisuke Arashi, Yusuke Kurihara, Tomoya Fujishiro, Takahiro Togashi, Toshiyuki Sakai, Masatoshi Muto, M. Takei, Hideki Ishii, Takeaki Saijo, Takehiko Matsumura, Naoyuki Obokata, Ming-Rong Zhang   +17 more
semanticscholar   +1 more source

Radiosynthesis and in silico bioevaluation of 131I‐Sulfasalazine as a highly selective radiotracer for imaging of ulcerative colitis

Chemical Biology and Drug Design, 2021
This study demonstrated the tracking of ulcerative colitis, which is considered a stressful immune disease. Although there are many ways to test for this disease including dependence on gases, dyes, and painful anal endoscopy, these treatment modalities ...
M. Sanad, S. F. Rizvi, A. Farag
semanticscholar   +1 more source

Nucleophilic radiosynthesis of boron neutron capture therapy-oriented PET probe [18F]FBPA using aryldiboron precursors.

Chemical Communications, 2021
A reliable copper-mediated nucleophilic radiosynthesis of the PET imaging probe [18F]FBPA was developed using novel aryldiboron precursors. The carrier-free [18F]FBPA with radiochemical purity >99% was prepared routinely via the two-step synthesis with ...
Jing He, Heng Yan, Yan-rong Du, Yan Ji, Fei Cai, Wenbin Fan, L. Huo, Yuan‐hao Liu, Zheng Wang, Shihong Li   +9 more
semanticscholar   +1 more source

Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol.

Journal of Visualized Experiments, 2021
The kynurenine pathway (KP) is a primary route for tryptophan metabolism. Evidence strongly suggests that metabolites of the KP play a vital role in tumor proliferation, epilepsy, neurodegenerative diseases, and psychiatric illnesses due to their immune ...
Xuyi Yue, Rahul M. Nikam, H. Kecskemethy, V. Kandula, Stephen J Falchek, L. Averill, Sigrid A. Langhans   +6 more
semanticscholar   +1 more source

Radiosynthesis of a Bruton's Tyrosine Kinase Inhibitor, [11 C]Tolebrutinib, via Palladium-NiXantphos-Mediated Carbonylation.

Journal of labelled compounds & radiopharmaceuticals, 2020
Bruton's tyrosine kinase (BTK) is a key component in the B-cell receptor signaling pathway, and is consequently a target for in vivo imaging of B-cell malignancies as well as in multiple sclerosis (MS) with positron emission tomography (PET).
K. Dahl, T. Turner, N. Vasdev
semanticscholar   +1 more source