Results 171 to 180 of about 6,098 (221)

Automated production of radiotracer [¹⁸F]FZTA for imaging sphingosine-1-phosphate receptor 1 (S1PR1) in human. [PDF]

Appl Radiat Isot
Qiu L, Bognar C, Tangadanchu VKR, Moerlein SM, Gaehle GG, Gropler RJ, Perlmutter JS, Benzinger TLS, Tu Z.   +8 more
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Fully Automated Azeotropic Drying-Free Synthesis of [¹⁸F]SynVesT-1 via Copper-Mediated Fluorination Using the Trasis All-in-One Module. [PDF]

Molecules
Basuli F, Shi J, Zhang X, Swenson RE.
europepmc   +1 more source

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An efficient radiosynthesis of [18F]fluoromisonidazole

Applied Radiation and Isotopes, 1993
An efficient preparation of the hypoxic cell tracer [18F]3-fluoro-1-(2'-nitro-1'-imidazolyl)-2-propanol ([18F]fluoromisonidazole) is reported. This radiopharmaceutical is of interest to probe hypoxic tissue in infarcts and tumors. One-step radiolabeling and rapid protection group removal provided 55-80% yield in 50 min. The process is similar to common
J L, Lim, M S, Berridge
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Automated radiosynthesis of [18F]ciprofloxacin

Applied Radiation and Isotopes, 2015
We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass ...
Johann, Stanek, Severin, Mairinger, Thomas, Wanek, Claudia, Kuntner, Markus, Müller, Oliver, Langer   +5 more
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The radiosynthesis of [-methyl-11C]-sertraline

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1989
[N-methyl-11C]Sertraline, a potential agent for the study of the serotonergic system in vivo with positron emission tomography, was prepared by N-methylation of the corresponding norcompound with [11C]iodomethane, which was itself prepared from cyclotron-produced [11C]carbon dioxide.
M C, Lasne, V W, Pike, D R, Turton
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Rapid and reproducible radiosynthesis of [18F] FHBG

Nuclear Medicine and Biology, 2004
9-(4-[18F] Fluoro-3-hydroxymethylbutyl) guanine ([18F] FHBG), an imaging agent for gene therapy using PET, was prepared in a one-pot, two-step synthesis. Microwave (MW) mediated nucleophilic fluorination of N2, monomethoxytrityl-9-[4-(tosyl)-3-monomethoxytrityl-methylbutyl] guanine using no-carrier-added [18F] fluoride, followed by deprotection with ...
Datta E, Ponde, Carmen S, Dence, Daniel P, Schuster, Michael J, Welch   +3 more
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Radiosynthesis of 18F-labeled d-allose

Carbohydrate Research, 2019
Rare sugars are defined as monosaccharides that exist in nature but are only present in limited quantities. d-Allose is a rare sugar that has been reported to have some unique physiological effects. The present study describes suitable synthetic procedures for novel rare sugars of d-allose that are 18F-labeled at the C-3 and C-6 positions and the ...
Hiroyuki, Yamamoto, Kenji, Wada, Jun, Toyohara, Tetsuro, Tago, Masanobu, Ibaraki, Toshibumi, Kinoshita, Yuka, Yamamoto, Yoshihiro, Nishiyama, Nobuyuki, Kudomi   +8 more
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Microfluidic reactor for the radiosynthesis of PET radiotracers

Applied Radiation and Isotopes, 2006
Here we show the first application of a microfabricated reaction system to PET radiochemistry, we term "microfluidic PET". The short half-life of the positron emitting isotopes and the trace chemical quantities used in radiolabelling make PET radiochemistry amenable to miniaturisation.
J M, Gillies, C, Prenant, G N, Chimon, G J, Smethurst, W, Perrie, I, Hamblett, B, Dekker, J, Zweit   +7 more
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The automated radiosynthesis of [18F]FP-TZTP

Nuclear Medicine and Biology, 2003
[(18)F]FP-TZTP (3-(3-(3-[(18)F]fluoropropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine) is a muscarinic ligand that displays in vivo selectivity for the M2 subtype. We have developed a one-step radiosynthesis of [(18)F]FP-TZTP that can be conducted with an automated synthesis unit. A number of hardware and software modifications to
Dale O, Kiesewetter, Bik-kee, Vuong, Michael A, Channing   +2 more
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A new precursor for the radiosynthesis of [ 18 F]FLT

Nuclear Medicine and Biology, 2002
In order to improve the [18F]FLT production for nuclear medical purposes, the syntheses and labeling results obtained with six new thymidine derivatives involving an alternative protection group strategy are described. The syntheses of the FLT-labeling precursors were performed using the following protection groups at the 5'-O-position: trityl (Tr) and
S J, Martin, J A, Eisenbarth, U, Wagner-Utermann, W, Mier, M, Henze, H, Pritzkow, U, Haberkorn, M, Eisenhut   +7 more
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