Results 181 to 190 of about 6,098 (221)

Radiosynthesis of Dextroamphetamine-14C Sulfate

Journal of Pharmaceutical Sciences, 1965
A high yield radiosynthesis of dl -amphetamine-7- 14 C was developed using 0.5 c. of benzoic-7- 14 C acid as the starting material. The dl -amphetamine-7 14 C was resolved in 84 per cent yields by the successive crystallization of d -amphetamine- 14 C d -bitartrate and l -amphetamine- 14 C l -bitartrate salts.
Dale Blackburn, Garth Burghard
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Radiosynthesis of NCA [carbonyl-11C]6-fluoromelatonin

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1988
A method is described for the preparation of [carbonyl-11C]6-fluoromelatonin for intravenous injection and potential study of the melatonin system in vivo by positron emission tomography. The preparation is based on the acetylation of 6-fluoro-5-methoxytryptamine with NCA [1-11C]acetyl chloride (itself prepared from cyclotron-produced [11C]carbon ...
D, Le Bars, S K, Luthra, V W, Pike, K L, Kirk   +3 more
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Solid Phase Reagents in Radiosynthesis

1995
Radiochemists rely heavily upon functionalized polymers and chromatographic supports for rapid isolation of radiochemicals and labeled intermediates. Extending the use of solid phase reagents from separation steps to radiolabeling reactions and organic transformations has many potential benefits; solid phase methods can shorten overall synthesis times,
G. Keith Mulholland, Douglas M. Jewett
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Radiosynthesis of 6-[C-11]-d-glucose

Applied Radiation and Isotopes, 1993
Availability of 6-[C-11]-D-glucose will permit positron emission tomography (PET) investigations of glucose utilization derived from the pentose shunt which supports biosynthesis in tissues. The first radiosynthesis of 6-[C-11]-D-glucose is described.
J R, Grierson, J E, Biskupiak, J M, Link, K A, Krohn   +3 more
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Gamma-ray radiosynthesis of ozone from air

The International Journal of Applied Radiation and Isotopes, 1966
Abstract Ozone concentrations were measured in static and flowing systems of air during γ-irradiation in Mark II Research Irradiator. In a flowing system, the concentration of ozone varied from 1.68 to 1.74 ppm over a dose range 50—1000 krad; the G values were about 11. In a static system the concentration varied from 7.36 ppm to 58.09 ppm, depending
J, Shah, E C, Maxie
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Radiosynthesis of [14C]acarbose.

Arzneimittel-Forschung, 1990
Acarbose (O-4,6-dideoxy-4-[[(1S, 4R, 5S, 6S)-4,5,6-trihydroxy-3- (hydroxymethyl)-2-cyclohexen-1-yl]amino]-a-D-glucopyranosyl-(1---- 4)-O-a-D- glucopyranosyl-(1----4)-4-glucopyranose, Bay g 5421), an a-glucosidase inhibitor from Actinoplanes, has been developed for the treatment of diabetes mellitus.
W, Maul, L, Müller, J, Pfitzner, E, Rauenbusch, H, Schutt   +4 more
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Positron Emission Tomography Radiosynthesis in Microreactors

Journal of Flow Chemistry, 2012
Positron emission tomography (PET) is a very powerful diagnostic technique routinely used in a variety of medical applications. This review article summarises the developments of using microreactor technology for the radiochemical synthesis of PETagents. The advantages of manufacturing these imaging drugs using microreactors are described, and a review
Paul Watts, Giancarlo Pascali, Piero A. Salvadori   +2 more
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A practical radiosynthesis of a tritium‐labelled fluorocombretastatin

Journal of Labelled Compounds and Radiopharmaceuticals, 2012
Zybrestat (combretastatin A‐4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent, and a radiolabelled version would enable further understanding of its biological activities.
John A. Hadfield, Nicholas Hirst, Keira Gaukroger, Nicholas J. Lawrence, Alan T. McGown   +4 more
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Improved radiosynthesis of 2-[123I]iodomelatonin

Applied Radiation and Isotopes, 1994
Abstract An improved method for the radiosynthesis of [ 123 I]melatonin is presented. The suitability of several oxidizing agents, such as Iodo-Gen, chloramine-T, hydrogen peroxide and in situ generated peracetic acid were evaluated for the oxidative radioiodination reactions.
D. Du T. Rossouw, J.H. Langenhoven
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A radiosynthesis of fluorine-18 fluoromisonidazole.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1989
A new preparation of [18F]fluoromisonidazole [1H-1-(3-[18F] fluoro-2-hydroxypropyl)-2-nitroimidazole] is presented as a two-step, two-pot reaction sequence. The method is useful for the production of 20-30 mCi quantities of this compound from [18F]fluoride, available in 40% radiochemical yield at end of bombardment (EOB) with a specific activity (nca ...
J R, Grierson, J M, Link, C A, Mathis, J S, Rasey, K A, Krohn   +4 more
openaire   +1 more source