Results 91 to 100 of about 829,320 (360)

Recurrence of rectal cancer : a study on patients with rectal cancer referred to Sir Paul Boffa Hospital during 2001-2003 [PDF]

, 2009
Surgery is the mainstay of treatment of rectal cancer. One third of all treatment failures are secondary to local recurrence usually leading to a painful and distressing death.
Brincat, Stephen, Said, Janabel, von Brockdorff, Luisa   +2 more
core  

Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer [PDF]

, 2013
Background : Preoperative radiotherapy (RT) decreases local recurrence rate and improves survival in stage II and III rectal cancer patients. The combination of chemotherapy with RT has a sound radiobiological rationale, and phase II trials of combined ...
Ceelen, Wim, DE CALUWE, LAURA, Van Nieuwenhove, Yves   +2 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Adjuvant Radiotherapy in Breast Cancer [PDF]

Breast Care, 2006
Locoregional external beam radiation therapy using linear accelerators is an essential component of a multimodal treatment concept with a curative intent after primary surgical therapy in non-invasive and locally confined invasive breast cancer. Its important role has been confirmed at the highest level of evidence by recent results of prospective ...
openaire   +1 more source

Role of Adjuvant Radiotherapy in Gastric Cancer

Journal of Gastric Cancer, 2023
Although continuous improvement in the treatment outcome of localized gastric cancer has been achieved through early screening, diagnosis, and treatment and the active application of surgery and adjuvant chemotherapy, the necessity of adjuvant radiotherapy (RT) remains controversial.
openaire   +2 more sources

Severe and prolonged myelosuppression during concomitant temozolomide and radiotherapy treatment in a patient with glioblastoma multiforme [PDF]

, 2015
Aims: We describe the case of a patient with glioblastoma (GBM) who developed severe and prolonged myelosuppression during concomitant daily temozolomide (TMZ) and radiotherapy (RT) treatment.
ALOE SPIRITI, Maria Antonietta, Carnevale, Alessia, Cox, Maria, DE SANCTIS, Vitaliana, Gentile, Giovanna, MAURIZI ENRICI, Riccardo, Minniti, Giuseppe, Porrini, ì Raffaele, Ruco, Luigi, Scaringi, Claudia, Simmaco, Maurizio, Tafuri, Agostino, Valeriani, Maurizio   +12 more
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Postoperative Radiotherapy in High-Risk Premenopausal Women with Breast Cancer Who Receive Adjuvant Chemotherapy

, 1997
Background Irradiation after mastectomy can reduce locoregional recurrences in women with breast cancer, but whether it prolongs survival remains controversial.
M. Overgaard, P. S. Hansen, J. Overgaard, C. Rose, M. Andersson, F. Bach, M. Kjaer, C. Gadeberg, H. Mouridsen, M. Jensen, K. Zedeler   +10 more
semanticscholar   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors

Breast Cancer Research, 2018
Background Adjuvant radiotherapy is the standard of care after breast-conserving surgery for primary breast cancer, despite a majority of patients being over- or under-treated.
Martin Sjöström, Johan Staaf, Patrik Edén, Fredrik Wärnberg, Jonas Bergh, Per Malmström, Mårten Fernö, Emma Niméus, Irma Fredriksson   +8 more
doaj   +1 more source