Results 81 to 90 of about 28,886 (305)

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Effect of replanning boost radiotherapy plan in locally advanced unresectable middle to lower thoracic esophageal cancer

Scientific Reports
Thoracic bulky esophageal cancer shrinks during radiotherapy, changing the location and shape of the surrounding heart and lungs. The current study aimed to explore how replanning by volumetric-modulated arc radiotherapy (VMAT) and three-dimensional ...
Hiroyuki Inoo, Katsuyuki Sakanaka, Takashi Mizowaki   +2 more
doaj   +1 more source

Impact of Treatment Technique on Testicular Dose and Sexual Activity in Rectal Cancer Patients

Brazilian Journal of Oncology
Objective To estimate the incidental radiation dose delivered to the testicles in three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) in rectal cancer patients ...
Poornachandra Tejaswi-Siddappa, Shamsundar Sunkappa, Jagannath Kunigal-Puttaswamy, Aradhana Katke, Nanda Ramanand, Thejaswini Boraiah   +5 more
doaj   +1 more source

Comparison of conformal radiotherapy, intensity-modulated radiotherapy and tomotherapy irradiation techniques in prostate cancers

, 2019
Aim The aim of this study is to compare three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT) and tomotherapy techniques used in the treatment of prostate cancer with target and critical organ doses to be included ...
Olacak, Nezahat, Tugrul, Taylan, Koylu, Murat   +2 more
core   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Feasibility of 2D‑conformal radiotherapy for pancreatic carcinoma

Oncology Letters, 2018
The purpose of the present study was to propose an optimized 2D technique (2D-conformal) for radiotherapy (RT) of pancreatic cancer (CaP). This technique is based on double simulation which resolves the problems of radiographic image distortion. Five patients with locally advanced CaP were identified and enrolled.
Buwenge, Milly, Cilla, Savino, Cammelli, Silvia, Macchia, Gabriella, Arcelli, Alessandra, Farina, Eleonora, Frakulli, Rezarta, Panni, Valeria, Wondemagegnhu, Tigeneh, Kamal Uddin, A. F. M., Sumon, Mostafa A., Deodato, Francesco, Morganti, Alessio G.   +12 more
openaire   +4 more sources

Three-dimensional conformal radiotherapy, static intensity-modulated and helical intensity-modulated radiotherapy in glioblastoma. Dosimetric comparison in patients with overlap between target volumes and organs at risk.

, 2014
Aims and background. Radiotherapy is the standard treatment of glioblastoma. Three-dimensional conformal radiotherapy is the standard technique to treat glioblastoma.
Saiani, Federica, Borghetti, Paolo, Spiazzi Luigi, BUGLIONE DI MONALE E BASTIA, Michela, Triggiani, Luca, Lazzari, Barbara, Costa, Loredana, Shehi, Blerina, MAGRINI, Stefano Maria, Pedretti, Sara, PANCIANI, PIER PAOLO, Pasinetti, Nadia, Uccelli, Chiara, Donadoni, Laura   +13 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

CT-PET guided target delineation in head and neck cancer and implications for improved outcome

, 2010
Aim: Fifty percent of patients with squamous cell carcinoma of the Head and Neck develop loco-regional recurrence after treatment. Factors leading to this failure are most likely altered intra-tumoural glucose metabolism and increased hypoxia ...
Moule, R.N.
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