Results 81 to 90 of about 300,304 (238)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Effect of replanning boost radiotherapy plan in locally advanced unresectable middle to lower thoracic esophageal cancer

Scientific Reports
Thoracic bulky esophageal cancer shrinks during radiotherapy, changing the location and shape of the surrounding heart and lungs. The current study aimed to explore how replanning by volumetric-modulated arc radiotherapy (VMAT) and three-dimensional ...
Hiroyuki Inoo, Katsuyuki Sakanaka, Takashi Mizowaki   +2 more
doaj   +1 more source

Impact of Treatment Technique on Testicular Dose and Sexual Activity in Rectal Cancer Patients

Brazilian Journal of Oncology
Objective To estimate the incidental radiation dose delivered to the testicles in three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and volumetric-modulated arc therapy (VMAT) in rectal cancer patients ...
Poornachandra Tejaswi-Siddappa, Shamsundar Sunkappa, Jagannath Kunigal-Puttaswamy, Aradhana Katke, Nanda Ramanand, Thejaswini Boraiah   +5 more
doaj   +1 more source

Analisys of Conformal Antennas for Avionics Applications [PDF]

, 2007
Conformal antennas might have an important impact on communication and navigation applications on aircraft, ships and other vehicles. This thesis work presents a general study on conformal antennas and their potential application on aircraft structures ...
Redondo Gonzalez, Maria del Carmen
core  

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Spatially Configurable Conformal Sensor Integration on an Ultra‐Fine Metallic Needle for Minimally Invasive Deep‐Tissue Oxygen Monitoring

Advanced Materials Technologies, EarlyView.
A multi‐point oxygen‐sensing ultra‐fine needle (MO‐UFN) is developed by conformally integrating a lithographically patterned flexible electrochemical sensor array onto a clinical acupuncture needle. The platform preserves an approximately 0.3 mm diameter while enabling spatially resolved oxygen profiling along the insertion pathway.
Yeju Seo, Jaeho Park, Yongrok Jeong, Ji‐Hwan Ha, Junseong Ahn, Jimin Gu, Su A Park, Ilwoo Jun, Kichul Lee, Inkyu Park   +9 more
wiley   +1 more source

A numerical conformal transformation method for harmonic mixed boundary value problems in polygonal domains [PDF]

, 1972
A method is given for solving two dimensional harmonic mixed boundary value problems in simply-connected polygonal domains with re-entrant boundaries.
Whiteman, J R, Papamichael, N
core   +4 more sources

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Conventional 3D conformal radiotherapy and volumetric modulated arc therapy for cervical cancer: Comparison of clinical results with special consideration of the influence of patient- and treatment-related parameters

, 2023
Purpose Intensity-modulated radiotherapy (IMRT) for cervical cancer yields favorable results in terms of oncological outcomes, acute toxicity, and late toxicity.
von Sivers, Franziska-Felicitas; Department of Radiotherapy and Radiation Oncology, University Medical Center Göttingen, Göttingen, Germany, Dröge, Leif Hendrik; Department of Radiotherapy and Radiation Oncology, University Medical Center Göttingen, Göttingen, Germany, Schirmer, Markus Anton, von Sivers, Franziska-Felicitas, Wolff, Hendrik Andreas; Department of Radiotherapy and Radiation Oncology, University Medical Center Regensburg, Regensburg, Germany, Schirmer, Markus Anton; Department of Radiotherapy and Radiation Oncology, University Medical Center Göttingen, Göttingen, Germany, Dröge, Leif Hendrik, Wolff, Hendrik Andreas   +7 more
core   +1 more source