Results 61 to 70 of about 28,886 (305)

Quality assurance in conformal radiotherapy: DYNARAD consensus report on practice guidelines [PDF]

, 1997
Background and purpose: Conformal radiotherapy has only recently been widely implemented. Although not all aspects have yet been adequately proven, it is generally recognized that maintaining a high degree of precision throughout the process is critical ...
Chierego, G., Ruden, B.I., Rosenwald, J.C., Kolitsi, Zoi, Rosenwald, Jean Claude, Dahl, Olav, Kolitsi, Z., van Loon, R., Drouard, J., Van Loon, Ronald, van Dijk, J.D.P., Van Dijk, Jan, Ruden, Bengt Inge, Drouard, Jean, Chierego, Giorgio, Dahl, O.   +15 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effects of Conformal Radiotherapy on Thyroid and Parathyroid Functions in Head-and-neck Carcinoma: A Single-institutional, Prospective, and Observational Study

Journal of Radiation and Cancer Research
Introduction: Assessment of acute and late effects of conformal radiotherapy on thyroid and parathyroid functions along with the evaluation of Dosimetric correlation with radiation-induced hypothyroidism (RIH) was the purpose of this study.
Rupasree Pal, Debottam Barman, Bodhisattwa Dutta, Bithi Pal, Snigdha Hazra, Asit Ranjan Deb   +5 more
doaj   +1 more source

Head and neck cancer in young adults treated with 3-D conformal radiotherapy [PDF]

Archive of Oncology, 2010
Background: Purpose of this study was to determine patterns of failure in young adults with head and neck cancer treated with 3-D conformal radiotherapy.
Stojkovski Igor, Krstevska Valentina, Mitreski Nenad, Stojkovska Eleonora, Simonova Daniela   +4 more
doaj   +1 more source

Clinical results of conformal versus intensity-modulated radiotherapy using a focal simultaneous boost for muscle-invasive bladder cancer in elderly or medically unfit patients

, 2016
For elderly or medically unfit patients with muscle-invasive bladder cancer, cystectomy or chemotherapy are contraindicated. This leaves radical radiotherapy as the only treatment option.
Arjan Bel, Rob M. van Os, Lutkenhaus, Lotte J., van Os, Rob M., Maarten C. C. M. Hulshof, Lotte J. Lutkenhaus, Bel, Arjan, Hulshof, Maarten C. C. M.   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

External beam accelerated partial breast irradiation: dosimetric assessment of conformal and three different intensity modulated techniques

Radiology and Oncology, 2019
The aim of the study was to evaluate and compare four different external beam radiotherapy techniques of accelerated partial breast irradiation (APBI) considering target coverage, dose to organs at risk and overall plan quality.
Stelczer Gábor, Major Tibor, Mészáros Norbert, Polgár Csaba, Pesznyák Csilla   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Prognostic factors in radiotherapy of anaplastic thyroid carcinoma: a single center study over 31 years

Radiation Oncology, 2023
Background Anaplastic thyroid carcinoma has a very poor prognosis. We analyzed the effect of surgery, radiotherapy and chemotherapy on survival time and side effects in patients with ATC.
Julia Jacob, Dirk Vordermark, Kerstin Lorenz, Daniel Medenwald   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source