Results 61 to 70 of about 300,304 (238)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Effects of Conformal Radiotherapy on Thyroid and Parathyroid Functions in Head-and-neck Carcinoma: A Single-institutional, Prospective, and Observational Study

Journal of Radiation and Cancer Research
Introduction: Assessment of acute and late effects of conformal radiotherapy on thyroid and parathyroid functions along with the evaluation of Dosimetric correlation with radiation-induced hypothyroidism (RIH) was the purpose of this study.
Rupasree Pal, Debottam Barman, Bodhisattwa Dutta, Bithi Pal, Snigdha Hazra, Asit Ranjan Deb   +5 more
doaj   +1 more source

External beam accelerated partial breast irradiation: dosimetric assessment of conformal and three different intensity modulated techniques

Radiology and Oncology, 2019
The aim of the study was to evaluate and compare four different external beam radiotherapy techniques of accelerated partial breast irradiation (APBI) considering target coverage, dose to organs at risk and overall plan quality.
Stelczer Gábor, Major Tibor, Mészáros Norbert, Polgár Csaba, Pesznyák Csilla   +4 more
doaj   +1 more source

COMPARISON IMPACT OF CONVENTIONAL VERSUS CONFORMAL RADIOTHERAPY TECHNIQUES ON THYROID IN BREAST CANCER IRRADIATION [PDF]

Zagazig University Medical Journal, 2019
Introduction: Adjuvant radiotherapy is considered one of treatment options for treatment of locally advanced breast cancer. Thyroid gland is not considered an organ at risk in supraclavicular (SC) nodal radiation therapy (RT) for breast cancer ...
Wael El-Sawy, Abd El Motaleb Ibrahim, Mohamed Refaat Abdel-Fattah*   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Radiotherapy Induced Thyroid Gland Dysfunction Among Patients With Head and Neck Cancers [PDF]

Zagazig University Medical Journal
Background: During the planning of 3D conformal radiotherapy for head and neck tumors, it is crucial to prioritize the dosage that reaches sensitive organs such as the thyroid gland. This is because there is a significant likelihood of developing thyroid
Nashwa Nawar, Ahmad AL-Hosainy, Sara Amin, Doaa Mandour   +3 more
doaj   +1 more source

Head and neck cancer in young adults treated with 3-D conformal radiotherapy [PDF]

Archive of Oncology, 2010
Background: Purpose of this study was to determine patterns of failure in young adults with head and neck cancer treated with 3-D conformal radiotherapy.
Stojkovski Igor, Krstevska Valentina, Mitreski Nenad, Stojkovska Eleonora, Simonova Daniela   +4 more
doaj   +1 more source

Highly-conformal intensity-modulated radiotherapy reduced toxicity without jeopardizing outcome in patients with paranasal sinus cancer treated by surgery and radiotherapy or (chemo)radiation

, 2012
Objectives: To report oncologic outcomes of patients with paranasal sinus cancer (PNSC) treated by surgery and radiotherapy or (chemo) radiation and to investigate the impact of improving the radiation technique on outcomes and toxicity.
Verduijn, Gerda, Hardillo, JAU (José), Al-Mamgani, Abrahim, Monserez, Dominiek, Levendag, Peter, Rooij, Peter   +5 more
core   +1 more source