Results 81 to 90 of about 1,908,615 (320)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Design of a magnetic-modulated target-selective X-ray tube to improve the energy distribution for intraoperative radiotherapy

Nuclear Engineering and Technology
Intraoperative radiotherapy with low-energy X-rays has potential advantages of high biological effects as well as moving flexibly. In addressing tumors of varying depths, there is a pressing need for adjustable spectral ranges and high emission ...
Limin Jin, Xi Zhang, Li Chen, Xiuli Hu, Yanze Sun   +4 more
doaj   +1 more source

Estimation of Secondary Skin Cancer Risk Due To Electron Contamination in 18-MV LINAC-Based Prostate Radiotherapy [PDF]

Iranian Journal of Medical Physics, 2016
Introduction Accurate estimation of the skin-absorbed dose in external radiation therapy is essential to estimating the probability of secondary carcinogenesis induction Materials and Methods Electron contamination in prostate radiotherapy was ...
Seyed Mostafa Ghavami, Hosein Ghiasi
doaj   +1 more source

microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. [PDF]

, 2017
Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote ...
Cao, Ke, Chen, Jia, Chen, Xiang, Chen, Yao, Chen, Yong, Cheng, Yan, Li, Jingjing, Qian, Li, Tang, Jintian, Tang, Shijie, Wang, Aijun, Xiong, Wei, Zhou, Jianda   +12 more
core   +1 more source

Very High-Energy Electron Therapy Toward Clinical Implementation

Cancers
Simple Summary This paper explores the potential of Very High Energy Electron (VHEE) beams, with energies between 50 and 400 MeV, as a promising option for cancer treatment.
Costanza Maria Vittoria Panaino, Simona Piccinini, M. Andreassi, Gabriele Bandini, Andrea Borghini, Marzia Borgia, Angelo Di Naro, L. Labate, Eleonora Maggiulli, M. Portaluri, L. Gizzi   +10 more
semanticscholar   +1 more source

First demonstration of the FLASH effect with ultrahigh dose-rate high energy X-rays

bioRxiv, 2020
The ultrahigh dose-rate (FLASH) radiotherapy, which is efficient in tumor control while sparing healthy tissue, has attracted intensive attention due to its revolutionary application prospect.
Feng Gao, Yiwei Yang, Hongyu Zhu, Jianxin Wang, D. Xiao, Zheng Zhou, T. Dai, Yu Zhang, G. Feng, Jie Li, B. Lin, G. Xie, Qi Ke, K. Zhou, Peng Li, X. Sheng, Hanbin Wang, Longgang Yan, C. Lao, Ming Li, Yanhua Lu, Menxue Chen, Jianheng Zhao, S. Feng, Xiaobo Du, Dai Wu   +25 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy using MAGAT Polymer Gel Dosimeter

Journal of Biomedical Physics and Engineering, 2019
Background: Numerous unique characteristics of the nanosized gold, including high atomic number, low toxicity, and high biocompatibility make it one of the most appropriate nanostructures to boost radiotherapy efficacy.
Farahani S., Riyahi Alam N., Haghgoo S., Khoobi M., Geraily Gh., Gorji E.   +5 more
doaj  

IPEM code of practice for high-energy photon therapy dosimetry based on the NPL absorbed dose calibration service

Physics in Medicine and Biology, 2020
The 1990 code of practice (COP), produced by the IPSM (now the Institute of Physics and Engineering in Medicine, IPEM) and the UK National Physical Laboratory (NPL), gave instructions for determining absorbed dose to water for megavoltage photon (MV ...
D. Eaton, G. Bass, P. Booker, J. Byrne, S. Duane, J. Frame, M. Grattan, R. Thomas, N. Thorp, A. Nisbet   +9 more
semanticscholar   +1 more source

放射線エネルギーの違いによる喉頭癌における吸収線量の影響 [PDF]

, 2002
We investigated the usefulness of Gafchromic MD-55 film (Nuclear Associates, Inc.) for measuring the radiation doses on the radiotherapy of laryngeal cancers. Since larynx has thin wedge-shaped structure in anterior neck adjacent to airway, the radiation
Aoyama, Hideki, Hiraki, Yoshio, Inamura, Keiji, Inoue, Mitsuhiro, Morioka, Yasuki, Nakagiri, Yoshitada, Tahara, Seiji, Uno, Hirofumi   +7 more
core   +1 more source