Results 41 to 50 of about 530,232 (219)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Hypofractionated stereotactic radiotherapy for brain metastases in lung cancer patients: dose‒response effect and toxicity

Discover Oncology
Background Lung cancer is a common cause of brain metastases, approximately 40% of patients with lung cancer will develop brain metastases at some point during their disease.
Kaicheng Pan, Bing Wang, Xiao Xu, Jiafeng Liang, Yi Tang, Shenglin Ma, Bing Xia, Lucheng Zhu   +7 more
doaj   +1 more source

Intraoperative radiation therapy for the treatment of recurrent retroperitoneal and pelvic tumors: a single-institution analysis

Radiation Oncology, 2018
Background Patients with recurrent retroperitoneal and pelvic region tumors often require multimodal therapies. Intraoperative radiation therapy (IORT) can deliver high-dose radiation to tumor beds, even if first-line external beam radiation therapy ...
Tharcisio Machado Coelho, Ricardo César Fogaroli, Antonio Cassio Assis Pellizzon, Douglas Guedes De Castro, Guilherme Rocha Melo Gondim, Maria Leticia Gobo Silva, Michael Jenwei Chen, Henderson Ramos   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

First-Line Guselkumab Combined with Exclusive Enteral Nutrition in Biologic-Naïve Young‑Onset Crohn’s Disease: A Three-Case Series from China

Journal of Inflammation Research
Sumei Sha,1 Bin Xu,2 Chenyang Qiao,1 Kairuo Wang,1 Le Liu,3 Jie Wu,4 Wenqi Ma,5 Ameng Shi,5 Xin Liu1 1Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of ...
Sha S, Xu B, Qiao C, Wang K, Liu L, Wu J, Ma W, Shi A, Liu X   +8 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Prognostic Significance of TMSB4X in Glioma Patients

International Journal of General Medicine
Sijie Li,1 Tianyi Fan,1 Zengyao Hao,1 Zizhou Zhang,1 Xuetao Han,1 Jiayuan Li,1 Yu Wang,1 Huandi Zhou,1– 3 Xiaoying Xue1,3 1Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of ...
Li S, Fan T, Hao Z, Zhang Z, Han X, Li J, Wang Y, Zhou H, Xue X   +8 more
doaj  

From IB2 to IIIB locally advanced cervical cancers: report of a ten-year experience

Radiation Oncology, 2018
Background Despite screening campaigns, cervical cancers remain among the most prevalent malignancies and carry significant mortality, especially in developing countries. Most studies report outcomes of patients receiving the usual standard of care.
Sophie Espenel, Max-Adrien Garcia, Jane-Chloé Trone, Elodie Guillaume, Annabelle Harris, Amel Rehailia-Blanchard, Ming Yuan He, Sarra Ouni, Alexis Vallard, Chloé Rancoule, Majed Ben Mrad, Céline Chauleur, Guy De Laroche, Jean-Baptiste Guy, Pablo Moreno-Acosta, Nicolas Magné   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Retrospective Analysis Comparing the Dosimetric Parameters of Two Rectum-Sparing Techniques During Intracavitary Brachytherapy with Tandem-Ring Applicators for Cervical Cancer

Cancer Management and Research
Siddharth Vats,1 Shabnum Thakur,2 Manish Gupta,1 Vineet Kumar,3 Lalit Chandrakant,1 Muninder Negi,4 Parul Sharma,1 Vikas Fotedar,1 Purnima Thakur,1 Deepak Tuli,1 Poorva Vias,2 Jyoti Sharma,5 Anup Negi,6 Shilpa Kaushal,7 Mrinalini Upadhyay,1 Naina Negi,1 ...
Vats S, Thakur S, Gupta M, Kumar V, Chandrakant L, Negi M, Sharma P, Fotedar V, Thakur P, Tuli D, Vias P, Sharma J, Negi A, Kaushal S, Upadhyay M, Negi N, Sharma A, Azad A, Parihar N, Verma D   +19 more
doaj