Results 141 to 150 of about 253,625 (250)
Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5787-5802, July 2026.ABSTRACT Aims Young adults (aged ≤ 40 years) are underrepresented in clinical trials that investigate interventions for those living with Type 2 diabetes (T2D). This study evaluated the efficacy of semaglutide treatment in young adults with T2D by examining the effects on HbA1c and body weight (BW) during the SUSTAIN and PIONEER programmes compared to ...
Francesco Zaccardi +8 more
wiley +1 more source
Advances in UrologyRadium-223 and enzalutamide have shown survival benefits in metastatic castration-resistant prostate cancer, and recent trial data suggest a potential synergy in combination.
Kenichi Hata +17 more
doaj +1 more source
New Phytologist, Volume 251, Issue 2, Page 721-736, July 2026.Summary Digitized herbarium specimens and iNaturalist observations provide invaluable plant biodiversity data. Combining these two data sources could create a more holistic representation of local biodiversity; however, understanding biases inherent to each is critical to determine how to best combine and utilize these data.
Rebecca C. Wilcox +5 more
wiley +1 more source
Mechanistic modelling of Radium-223 treatment of bone metastases
, 2018 INTRODUCTION: Despite the effectiveness of 223RaCl2 for treating patients with symptomatic bone metastatic disease, its mechanisms of action are still unclear. Even established dosimetric approaches differ considerably in their conclusions.
O'Sullivan, Joe M; id_orcid +4 more
core +1 more source
Южно-Российский онкологический журналPurpose of the study. Assessment of clinical safety and effectiveness of radium‑223 in patients with bone metastases from castration-resistant prostate cancer.Patients and methods.
O. I. Kit +9 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Schema for patient flow for the radium-223 pharmacodynamic study.
, 2019 Schema for patient flow for the radium-223 pharmacodynamic study.
Colin Rothwell (6743741) +20 more
core +1 more source
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, Volume 36, Issue 44, 1 June 2026.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin +10 more
wiley +1 more source
, 2013 Michael R Harrison, Terence Z Wong, Andrew J Armstrong, Daniel J GeorgeDuke Cancer Institute, Durham, NC, USABackground: Radium-223 chloride (223Ra; Alpharadin) is an alpha-emitting radioisotope that targets areas of osteoblastic metastasis and is ...
Wong TZ +3 more
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