Results 51 to 60 of about 9,194 (267)

Radium-223 in metastatic castration resistant prostate cancer

Asian Journal of Andrology, 2014
In 2004, docetaxel was approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). For the next several years, there was a lull in drug approvals.
Winston Vuong, Oliver Sartor, Sumanta K Pal   +2 more
doaj   +1 more source

Radium-223 in combination with paclitaxel in cancer patients with bone metastases : safety results from an open-label, multicenter phase Ib study [PDF]

, 2017
Purpose Concomitant treatment with radium-223 and paclitaxel is a potential option for cancer patients with bone metastases; however, myelosuppression risk during coadministration is unknown.
Danson, Sarah, Geva, Ravit, Harris, Samuel J., Joensuu, Heikki, Lopez, Juanita, Peer, Avivit, Pereira, Kaline M. C., Perets, Ruth, Souza, Fabricio   +8 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Evaluation of a novel EHR sidecar application to display RA clinical outcomes during clinic visits: results of a stepped‐wedge cluster randomized pragmatic trial

Arthritis Care &Research, Accepted Article.
Objective We developed a novel EHR sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk, Jing Li, Cathy Nasrallah, Cherish Wilson, Alicia Hamblin, Christine Hariz, Cammie Young, Stephen Shiboski, Emma Kersey, Mary Nakamura, Judith F. Ashouri, Mehrdad Matloubian, Andrew J. Gross, Jennifer Barton, Beth Berrean, Jonathan Prugh, Jinoos Yazdany   +16 more
wiley   +1 more source

Retrospective Toxicological Profiling of Radium-223 Dichloride for the Treatment of Bone Metastases in Prostate Cancer Using Adverse Event Data

Medicina, 2019
Background and Objective: Radium-223 dichloride (Xofigo®) is a calcium mimetic agent approved for the treatment of castration-resistant prostate cancer patients with symptomatic bone metastases and no known visceral metastatic disease. This targeted,
Theodoros G. Soldatos, Ioannis Iakovou, Christos Sachpekidis   +2 more
doaj   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, Accepted Article.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Differences in Trial and Real-world Populations in the Dutch Castration-resistant Prostate Cancer Registry [PDF]

, 2016
__Background:__ Trials in castration-resistant prostate cancer (CRPC) treatment have shown improved outcomes, including survival. However, as trial populations are selected, results may not be representative for the real-world population. The aim of this
Beerlage, H.P. (Harrie), Bloemendal, H.J. (Haiko), Boerma, M.O. (Michiel), Bos, M.M.E.M. (Monique ), Coenen, J.L.L.M. (Jules), Cordia, I. (Igor), Eertwegh, A.J.M. (Fons) van den, Geenen, M.M. (Maud M.), Gerritsen, W.R. (Winald), Hendriks, M.P. (Mathijs), Moorselaar, R.J.A. van, Peters, F.P. (Frank), Polee, M.B. (Marco), Spermon, R.J. (Roan), Tick, L.W. (Lidwine), Uyl-de Groot, C.A. (Carin), Van Den Berg, P. (Pieter), Van Den Bergh, H. (Huub), Van Den Bosch, J. (Joan), Vos, A.I. (Aad) de, Westgeest, H.M. (Hans), Wit, R. (Ronald) de, Wouw, A.J. (Agnès) van de   +22 more
core   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐modifying Antirheumatic Drug

Arthritis Care &Research, Accepted Article.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD) Methods PrismRA incorporated 19 gene expression features and 4 clinical features to assess a patient's likelihood of ...
Fenglong Xie, Timothy Beukelman, Nicholas P McCormick, Jeffrey R Curtis   +3 more
wiley   +1 more source

The Curies’ element: state of the art and perspectives on the use of radium in nuclear medicine

EJNMMI Radiopharmacy and Chemistry, 2023
Background The alpha-emitter radium-223 (223Ra) is presently used in nuclear medicine for the palliative treatment of bone metastases from castration-resistant prostate cancer.
Sara Franchi, Mattia Asti, Valerio Di Marco, Marianna Tosato   +3 more
doaj   +1 more source

Transformative Bioactive Wear Resistant Ti3Au:N and Ti3Au:O Coatings for Medical Implants and Devices

Advanced Healthcare Materials, EarlyView.
Coatings of titanium‐gold are grown in nitrogen and oxygen environments via magnetron sputtering to simultaneously enhance their biotribological and antibacterial properties. The coatings are highly crystalline with superhard scratch‐resistant surfaces and wear rates 20 times lower than the bare Ti‐6Al‐4V substrate.
Cecil Cherian Lukose, Ioannis Anestopoulos, Iraklis‐Stavros Panagiotidis, Guillaume Zoppi, Anna M Black, Lynn G. Dover, Leon Bowen, Ángel Serrano‐Aroca, Lorenzo Mendola, Davide Morrone, Mihalis I. Panayiotidis, Martin Birkett   +11 more
wiley   +1 more source