Results 61 to 70 of about 5,929 (217)

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Report on Correlation between Radon Outgassing and Aftershocks Activity along the Bam Fault in Kerman Province of Iran

Brazilian Journal of Radiation Sciences, 2017
After the Earthquake in Bam in December 26, 2003, a team was dispatched to this area to monitor the relationship between Variation in the Radon (222Rn) concentration and the magnitude of aftershocks.
Abdollah Khorshidi, Jamshid Soltani Nabipour   +1 more
doaj   +1 more source

ALDH2 Suppresses Ferroptosis and Promotes Bortezomib Resistance in Multiple Myeloma Through the KEAP1‐NRF2 Feedback Loop

Advanced Science, EarlyView.
ALDH2, which is overexpressed in multiple myeloma, competitively binds KEAP1 to stabilize NRF2 by blocking its ubiquitin‐proteasomal degradation. Stabilized NRF2 translocates into the nucleus to upregulate the expression of GPX4. In parallel, NRF2 binds to the ALDH2 promoter to regulate its transcription, forming a positive feedback loop that represses
Ruonan Shao, Chengcheng Liu, Xinpei Deng, Jindong Xie, Wenjian Liu, Bin Yang, Lingrui Liu, Cailu Song, Lei Li, Hua Wang, Hailin Tang   +10 more
wiley   +1 more source

Study on calibration factor of radon measurement in scintillation chamber at different times

四川大学学报. 自然科学版, 2023
In order to calibrate the concentration of radon in scintillation chamber quickly, this paper proposes a method to calibrate the radon concentration by obtaining the calibration factor of measuring radon in scintillation chamber at different times ...
ZHANG Shu-Yan, LI Zhi-Qiang, XU Yong, ZHANG Mi, LI Wei-Gang, LI Yan-Qiu, ZHANG Deng-Yu   +6 more
doaj  

Spatiotemporally Precise Rheumatoid Arthritis Therapy via a Triple‐Locked Cascaded Nanoplatform With Dual‐Channel Self‐Reporting

Advanced Science, EarlyView.
An orthogonally programmable nanotheranostic (MB@YW NPs) enables precision therapy for rheumatoid arthritis. A triple‐locked (pH, HOCl/ONOO−, light) independently drives the release of methotrexate and sulfasalazine. Trackable by dual‐channel fluorescence, this coordinated drug delivery remodels the inflammatory microenvironment to markedly suppress ...
Jihong Liu, Wendi Zhu, Shiyun Xu, Shichang Liu, Wenjun Tang, Xiaoyu Ma, Ting Yang, Haojian Yang, Hongtong Wang, Lu Cao, Lijie Tan, Qi Wang   +11 more
wiley   +1 more source

MRSA‐Triggered Disassembly of an Immune‐Recruiting NIR Probe for Bacterial Imaging and Clearance

Advanced Science, EarlyView.
A bacteria–immune cell‐bridging supramolecular amphiphile, Dman‐C11, undergoes MRSA membrane‐triggered disassembly to activate NIR fluorescence and photodynamic killing, inducing ferroptosis‐like bacterial death and immune‐assisted clearance in wound infection and keratitis models.
Jiacheng Du, Yongyi Chen, Ling Lei, Yunzhe Tao, Yu Peng, Qingyang Zhang, Qinghua Wang, Hai‐Yu Hu   +7 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

KARAELMAS YERLEŞKESİ MERKEZ KÜTÜPHANESİ RADON ÖLÇÜMLERİ

Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2010
Özet: Bina içindeki doğal radyoaktivitenin başlıca sorumlusu radondur. Radon solunması yoluyla radyasyona maruz kalan kişilerin aldığı dozların hesaplanabilmesi için bina içi radon konsantrasyonunun belirlenmesi önemlidir.
Mehmet KÜRKÇÜOĞLU, Bülent HANER, Alaattin YILMAZ, İhsan TOROĞLU   +3 more
doaj  

Ventilation approaches and radon control in Canadian houses

Frontiers in Public Health
IntroductionBalanced mechanical ventilation with heat (sensible heat only) or energy (sensible and latent heat) recovery has the potential to dilute indoor radon and may be an appropriate first step at reducing moderate indoor radon concentration in a ...
Janet Gaskin, Liang Grace Zhou, Yunyi Ethan Li, Patrique Tardif   +3 more
doaj   +1 more source

Experimental and numerical study of liquid–liquid systems using the Euler–Lagrange/VOF approach

AIChE Journal, EarlyView.
Abstract Achieving stable liquid–liquid dispersions with controlled droplet size remains a challenge due to the complex interplay of dispersed phase viscosity, hydrodynamic conditions and interfacial interactions. This work presents a validated computational framework for droplet breakage and coalescence in liquid–liquid dispersions with variable ...
Pavel Krýsa, Vojtěch Koutník, Simon Kuhn, Miroslav Šoóš   +3 more
wiley   +1 more source