Results 221 to 230 of about 60,399 (263)

Case report: Successful use of MEK inhibitors as an adjuvant approach in the treatment of pediatric MAP4-RAF1 fusion-positive solid tumor. [PDF]

NPJ Precis Oncol
Yang S, Zhang S, Wang J, Zhang N, Wang J, Jiang M, Meng D, Xie J, Chang X, Cheng H, Wang H.   +10 more
europepmc   +1 more source

RAF inhibitors activate the integrated stress response by direct activation of GCN2. [PDF]

Nat Commun
Gilley R, Kidger AM, Neill G, Morrison E, Severson P, Byrne DP, Kenneth NS, Bollag G, Zhang C, Maia de Oliveira T, Eyers PA, Bayliss R, Masson GR, Cook SJ.   +13 more
europepmc   +1 more source

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif-mediated asymmetric BRAF dimer

Kondo Y, Notbohm J, Navas Camacho I, Nagy-Davidescu G, Mason T, Mühle J, Standfuss J, Perica T.   +7 more
europepmc   +1 more source

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RKIP: Much more than Raf Kinase inhibitory protein

Journal of Cellular Physiology, 2013
AbstractFrom its discovery as a phosphatidylethanolamine‐binding protein in bovine brain to its designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical molecule for maintaining subdued, well‐orchestrated cellular responses to stimuli.
Fahd, Al-Mulla, Milad S, Bitar, Zainab, Taqi, Kam C, Yeung   +3 more
openaire   +2 more sources

Raf kinase inhibitory protein inhibits β-cell proliferation

Surgery, 2004
Raf-1 kinase inhibitory protein (RKIP) was recently identified as a physiologic endogenous inhibitor of the extracellular signal-regulated kinase (ERK) pathway. The expression and role of RKIP within the pancreas are unknown.RKIP expression in normal pancreas and human insulinomas was examined by using paraffin-embedded sections.
Lizhi, Zhang, Zheng, Fu, Charles, Binkley, Thomas, Giordano, Charles F, Burant, Craig D, Logsdon, Diane M, Simeone   +6 more
openaire   +2 more sources

Raf-1 Kinase Inhibitory Protein Expression in Thyroid Carcinomas

Endocrine Pathology, 2010
Raf-1 kinase inhibitory protein (RKIP) has been implicated in several fundamental signal transduction pathways that control cellular growth, differentiation, apoptosis and migration. RKIP is reduced in a variety of human carcinomas, but RKIP expression in thyroid carcinomas has not been analyzed at the protein level.
Hyun-Soo, Kim, Gou Young, Kim, Sung-Jig, Lim, Youn Wha, Kim   +3 more
openaire   +2 more sources

Regulation of the MAPK Pathway by Raf Kinase Inhibitory Protein

Critical Reviews in Oncogenesis, 2014
The Raf kinase inhibitor protein 1 (RKIP-1) was the first reported endogenous inhibitor of Raf-1-MEK-ERK/MAPK cascade, by interfering with the phosphorylation of MEK by Raf-1. However, RKIP's functions related to the MAPK signaling are far more complex.
Drieke, Vandamme, Ana, Herrero, Fahd, Al-Mulla, Walter, Kolch   +3 more
openaire   +2 more sources

RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility

Mol. BioSyst., 2011
RKIP-1 is a metastasis suppressor that is frequently downregulated in aggressive cancers. However, the consequences of RKIP loss in primary or immortalized cells have not yet been explored. Using HEK-293 RKIP depleted (termed HEK-499) and Flp-In T-Rex-293 RKIP inducible cell lines combined with whole transcriptome analysis, we show that RKIP-1 ...
Fahd, al-Mulla, Milad S, Bitar, Zainab, Taqi, Oliver, Rath, Walter, Kolch   +4 more
openaire   +2 more sources

Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma

Pathology, 2010
Raf-1 kinase inhibitor protein (RKIP) has emerged as a significant metastatic suppressor in a variety of human cancers. The aim of this study was to evaluate RKIP expression and to determine its association with metastasis and prognostic significance in pancreatic cancer patients.Immunohistochemical staining for RKIP was performed on 63 cases of ...
Hyun-Soo, Kim, Gou Young, Kim, Sung-Jig, Lim, Youn Wha, Kim   +3 more
openaire   +2 more sources