Results 91 to 100 of about 89,257 (292)

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Facile conversion of RAFT polymers into hydroxyl functional polymers: A detailed investigation of variable monomer and RAFT agent combinations

, 2010
We report the systematic investigation of a recently introduced one-pot radical transformation of methacrylate and acrylate-type polymers prepared via reversible addition fragmentation chain transfer (RAFT) polymerization into hydroxyl functional ...
Schmid, C., Schmid, Christina, Falkenhagen, Jana, Gruendling, T., Falkenhagen, J., Dietrich, M., Barner-Kowollik, C., Glassner, M.   +7 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Expansion Microscopy Reveals the Spatial Association of Therapeutic Antibody–Receptor Complexes With Cholesterol‐Rich Membrane Domains

Angewandte Chemie, EarlyView.
We report a super‐resolution strategy that maps cholesterol‐rich membrane domains in whole, intact cells with an effective spatial resolution of ∼40 nm by combining expansion microscopy with a perfringolysin O domain 4 probe. This approach enables direct visualization of the spatial association between CD20 and CD38 complexes and cholesterol‐rich ...
Gang Wen, Nicole Seifert, Patrick Eiring, Johanna Meyer, Hannes Neuweiler, Julia Weingart, Ignacio Vega‐Vásquez, Sören Doose, Philip Kollmannsberger, Markus Sauer   +9 more
wiley   +2 more sources

Food allergy and mass catering: how to better accommodate allergic school children? Taking stock of an experience conducted in Franche-Comté region, France

World Allergy Organization Journal, 2020
Laetitia Pellicer-Garcia, Angélique Doc, Emilie Capelli, Jean-Charles Dalphin, Pauline Roux, Jean- Marc Rame   +5 more
doaj   +1 more source

Designer ligands: The search for metal ion selectivity

South African Journal of Science, 2011
The paper reviews research conducted at Rhodes University towards the development of metal-selective ligands. The research has focused on the rational design, synthesis and evaluation of novel ligands for use in the formation of copper complexes as ...
Perry Kaye
doaj  

RAFT-mediated polymerization-induced self-assembly of poly(ionic liquid) block copolymers in a green solvent

e-Polymers
Synthesis of the poly(N,N-dimethylacrylamide)-b-poly(1-alkyl-3-(4-vinylbenzyl)imidazolium tetrafluoroborate) (PDMA43-b-PILx) block copolymers prepared by RAFT ethanol dispersion polymerization at 70°C.
Yang Yongqi, Ren Zekai, Li Xiawei, Zhao Enhao, Luo Xin, Yan Youjun, Gao Hongyan, Feng Lijuan   +7 more
doaj   +1 more source

Supplementary Materials and Methods; Supplementary Figures S1-S5; and Supplementary Tables S1-S5 from α_Vβ₃ Integrin-Targeted Radionuclide Therapy with ⁶⁴Cu-cyclam-RAFT-c(-RGDfK-)₄

, 2016
The files contain (1) Supplementary Materials and Methods for αVβ3 expression analysis, autoradiography and histological analysis, and hematology and hepatorenal function; (2) Supplementary Tables S1-S5; and (3) Supplementary Figures S1-S5.Table S1â ...
Takako Furukawa (199756), Kazunori Kawamura (136818), Ming-Rong Zhang (136828), Pascal Dumy (8679), Didier Boturyn (32114), Yasuhisa Fujibayashi (416891), Tsuneo Saga (342370), Tomoteru Yamasaki (136789), Mélissa Degardin (5424740), Zhao-Hui Jin (32111), Aya Sugyo (389882), Atsushi B. Tsuji (389880)   +11 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Hydraulicity in Organic Polymers Enabled by Hydrophobization Upon Water‐Triggered Curing of Hydrophilic Chains

Angewandte Chemie, EarlyView.
Cement‐mimetic hydraulicity is realized in an organic polymer through a counterintuitive reaction in which a hydrophilic linear polymer reacts with water to undergo hydrophobization during curing via silatrane sol–gel chemistry. This polarity‐inverting curing process turns a water‐plasticized putty into a water‐tolerant rigid material, enabling ...
Rei Tokumitsu, Shio Uebo, Akira Takahashi, Hideyuki Otsuka   +3 more
wiley   +2 more sources