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RAGE Signaling in Skeletal Biology [PDF]

open access: yesCurrent Osteoporosis Reports, 2019
PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Lilian I Plotkin   +2 more
exaly   +4 more sources

The AGE–RAGE–oxidative stress axis: A paradigm shift in understanding diabetic retinopathy [PDF]

open access: yesIndian Journal of Ophthalmology
Diabetic retinopathy (DR) represents a vision-threatening complication of diabetes, characterized by progressive damage to the retinal neurovascular network in both type 1 and type 2 diabetes.
Riya Srivastava   +5 more
doaj   +2 more sources

阿司匹林和氯吡格雷联合应用 对小鼠脑缺血恢复期RAGE及 sRAGE表达的影响 Effects of Aspirin Combined with Clopidogrel on the Expression of RAGE and sRAGE during the Convalescence of Cerebral Ischemia in Mice

open access: yesZhongguo cuzhong zazhi, 2022
目的 探索阿司匹林和氯吡格雷联合应用对小鼠大脑中动脉远端缺血再灌注模型恢复期晚期糖基化终末产物受体(receptor for advanced glycation end products,RAGE)及可溶性晚期糖基化终末产物受体(soluble receptor for advanced glycation end products,sRAGE)表达的影响及其机制。 方法 60只C57BL/6J雄性小鼠随机分为假手术组、溶剂组、阿司匹林和氯吡格雷联合组(双抗组),每组20只 ...
温少红, 刘向荣, 顺英, 董雯, 陈青芳, 陈文涛, 李子孝, 王春娟
doaj   +1 more source

Electroacupuncture inhibits the expression of HMGB1/RAGE and alleviates injury to the primary motor cortex in rats with cerebral ischemia

open access: yesTranslational Neuroscience, 2023
The high-mobility group box 1 (HMGB1)/receptor for advanced glycation end products (RAGE) signaling pathway holds promise as a potential therapeutic target for ischemic brain injury. The effects of FPS-ZM1 and electroacupuncture (EA) on activation of the
Nie Zeyin   +3 more
doaj   +1 more source

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia [PDF]

open access: yes, 2020
Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy
Chiappalupi, S.   +9 more
core   +1 more source

Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases

open access: yesAntioxidants, 2020
Diets are currently characterized by elevated sugar intake, mainly due to the increased consumption of processed sweetened foods and drinks during the last 40 years. Diet is the main source of advanced glycation endproducts (AGEs).
Vanesa Cepas   +3 more
doaj   +1 more source

Inflammatory signaling of HMGB1 in depressive disorder

open access: yesStress and Brain, 2023
Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang   +4 more
doaj   +1 more source

The receptor for advanced glycation end products (RAGE) contributes to the progression of emphysema in mice [PDF]

open access: yes, 2015
Several recent clinical studies have implied a role for the receptor for advanced glycation end products (RAGE) and its variants in chronic obstructive pulmonary disease (COPD).
Leme, AS   +3 more
core   +10 more sources

Anger: what we know and what we don't want to know. Scientific contributions and social representation.

open access: yesMediterranean Journal of Clinical Psychology, 2020
Introduction: Aggressiveness is an essential component of every living thing and the experience of anger is common to all historical periods, all ages and all mental structures. Different forms and narrative ways of anger can be found in each society and
Paola Manfredi
doaj   +1 more source

Identification of Alpha and Beta Coronavirus in Wildlife Species in France: Bats, Rodents, Rabbits, and Hedgehogs

open access: yesViruses, 2017
Coronaviruses are closely monitored in the context of emerging diseases and, as illustrated with Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-coronavirus (MERS-CoV), are known to cross the species barrier ...
Elodie Monchatre-Leroy   +6 more
doaj   +1 more source

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