Results 11 to 20 of about 498,772 (347)
RAGE signaling regulates the progression of diabetic complications
Frontiers in Pharmacology, 2023 Diabetes, the ninth leading cause of death globally, is expected to affect 642 million people by 2040. With the advancement of an aging society, the number of patients with diabetes having multiple underlying diseases, such as hypertension, obesity, and ...
K. Taguchi, K. Fukami
semanticscholar +1 more source
AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration
Frontiers in Molecular Neuroscience, 2023 Advanced glycation end-products (AGEs; e.g., glyoxal, methylglyoxal or carboxymethyl-lysine) are heterogenous group of toxic compounds synthesized in the body through both exogenous and endogenous pathways.
Reshmee Bhattacharya +4 more
semanticscholar +1 more source
RAGE Inhibitors in Neurodegenerative Diseases
Biomedicines, 2023 Nonenzymatic reactions of reducing sugars with primary amino groups of amino acids, proteins, and nucleic acids, followed by oxidative degradations would lead to the formation of advanced glycation endproducts (AGEs).
Federica Laudisi +4 more
semanticscholar +1 more source
Molecular Medicine, 2023 Objective To elucidate the mechanism whereby advanced glycation end products (AGEs) accelerate atherosclerosis (AS) and to explore novel therapeutic strategies for atherosclerotic cardiovascular disease.
Meng Shu +11 more
semanticscholar +1 more source
Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases
Molecules, 2022 As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high ...
Qing Yue +5 more
semanticscholar +1 more source
Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia.
Cell Reports, 2022 Microglia-mediated neuroinflammation and α-synuclein (α-syn) aggregation, both as pathological hallmarks of Parkinson's disease (PD), crosstalk to exacerbate degeneration of dopaminergic neurons and PD progression. However, the mechanism underlying their
Houfang Long +6 more
semanticscholar +1 more source
Drug development research (Print), 2022 Receptor for advanced glycation end products (RAGE) is a 45 kDa transmembrane receptor of immunoglobulin family that can bind to various endogenous and exogenous ligands and initiate the inflammatory downstream signaling pathways.
Harbinder Singh, D. Agrawal
semanticscholar +1 more source
The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes
International Journal of Molecular Sciences, 2022 There is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood.
M. Snelson, Elisa Lucut, M. Coughlan
semanticscholar +1 more source
RAGE promotes dysregulation of iron and lipid metabolism in alcoholic liver disease
Redox Biology, 2022 Alcoholic liver disease (ALD) is associated with hepatic inflammatory activation and iron overload. The receptor for advanced glycation end products (RAGE) is an important metabolic mediator during the development of ALD.
Yunjia Li +15 more
semanticscholar +1 more source
For a Research Agenda on Negative Politics
Politics and Governance, 2022 This thematic issue deals with the “negative” side of politics, more specifically with dynamics of political aggressiveness and ideological opposition in voters and elites. Why do candidates “go negative” on their rivals?
Alessandro Nai +4 more
doaj +1 more source