Results 31 to 40 of about 78,533 (307)

Marked reduction of SARS-CoV-2 infection and improved recovery following supplementation with a probiotic mix of four strains and two strains of Bifidobacterium breve in hamsters

open access: yesApplied and Environmental Microbiology
Only a few studies have shown that certain probiotics have beneficial effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this study, two strains of Bifidobacterium breve, CNCM I-5644 and CNCM I-5979, selected for their ...
Edgar Torres-Maravilla   +11 more
doaj   +1 more source

Enhanced RAGE Expression and Excess Reactive-Oxygen Species Production Mediates Rho Kinase-Dependent Detrusor Overactivity After Methylglyoxal Exposure

open access: yesFrontiers in Physiology, 2022
Methylglyoxal (MGO) is a highly reactive dicarbonyl compound implicated in diabetes-associated diseases. In vascular tissues, MGO induces the formation of advanced glycation end products (AGEs) that bounds its receptor RAGE, initiating the downstream ...
Akila L. Oliveira   +5 more
doaj   +1 more source

RAGE Architecture for Reusable Serious Gaming Technology Components [PDF]

open access: yes, 2016
For seizing the potential of serious games, the RAGE project - funded by the Horizon-2020 Programme of the European Commission - will make available an interoperable set of advanced technology components (software assets) that support game studios at ...
Georgiev, Atanas   +10 more
core   +1 more source

RAGE signalling in obesity and diabetes: focus on the adipose tissue macrophage

open access: yesAdipocyte, 2020
The advanced glycosylation end product receptor (RAGE) acts as a recognition receptor and interacts with different types of ligands that form and accumulate in the tissues and circulation, such as diabetes, inflammation, insulin resistance, and obesity ...
Ziqian Feng, Luochen Zhu, Jianbo Wu
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

La pasión explosiva: una conceptualización de la ira política

open access: yesRevista de Estudios Sociales
In recent years, anger has emerged as a crucial category for analyzing contemporary political phenomena such as democratic elections, protests, collective violence, social movements, and crises of institutional representation. However, it has also become
Iván Garzón Vallejo
doaj   +1 more source

RAGE-learning ABM extension - model outputs corresponding to ECOMOD publication

open access: yes, 2023
This data repository pertains to outputs of an agent-based model as described and analyzed in the following publication:The data has been generated with the extended agent-based model RAGE-learning, which is available at ComSES (see below). Full citation
Valeria Javalera Rincón (17711812)   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

D1.1 – Applied gaming asset methodology [PDF]

open access: yes, 2017
Together with the intermediate deliverable D1.4 (Month 18), this document explains how the RAGE project defines, develops, distributes and maintains a series of applied gaming software assets through a high-level methodology and infrastructure that are ...
Mascarenhas, Samuel   +16 more
core  

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