Results 201 to 210 of about 1,445 (260)

Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources

The FEBS Journal, Volume 293, Issue 15, Page 4645-4659, August 2026.
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani, Marco Gargiulo, Elia Lio, Enrico Mario Alessandro Fassi, Giovanni Grazioso, Maria Assunta Chiacchio, Barış Binay, Stefania Brocca, Francesco Secundo   +8 more
wiley   +1 more source

Multicolor Mechanochromic Polymer Blends That Can Distinguish between Tensile-Stress States. [PDF]

Macromol Rapid Commun
Ishizuki K, Takahashi A, Otsuka H.
europepmc   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, Volume 293, Issue 15, Page 4724-4743, August 2026.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

PAS-Domain Protein Orientation at a Polyelectrolyte Surface Revealed by Infrared Nanospectroscopy, Chiral Vibrational Spectroscopy, and Molecular Dynamics Simulations. [PDF]

Biomacromolecules
Bogár F, Román Quintero M, Horváth J, Násztor Z, Mero M, Krekic S, Veber A, Puskar L, Dér A, Heiner Z.   +9 more
europepmc   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, Volume 293, Issue 15, Page 4680-4703, August 2026.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

<i>Aeromonas hydrophila</i> RTX adhesin has three ligand-binding domains that give the bacterium the potential to adhere to and aggregate a wide variety of cell types. [PDF]

mBio
Ye Q, Eves R, Vance TDR, Hansen T, Sage AP, Petkovic A, Bradley B, Escobedo C, Graham LA, Allingham JS, Davies PL.   +10 more
europepmc   +1 more source

The Structure of Vertebrate Antigen Receptor Repertoires: An Evolutionary Perspective

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT In vertebrate adaptive immune systems, somatically diversified antigen receptors assume a central role in self/nonself discrimination. Attesting to the presence of a unique but unknown selective environment at early stages of vertebrate evolution, this facility emerged twice, in the ancestors of jawless and jawed vertebrates.
Thomas Boehm, Orlando B. Giorgetti
wiley   +1 more source

Dietary Supplementation with Whole-Fat or Defatted Antarctic Krill Powder Improves the Growth Performance, Body Coloration, and Immune Capability of Red-White Koi Carp (<i>Cyprinus carpio</i> var. koi). [PDF]

Animals (Basel)
Song H, Liang Y, Yang Y, Liu C, Liu Y, Mu X, Wang X.   +6 more
europepmc   +1 more source

Growth and histomorphological responses of Chindongo socolofi to the long‐term replacement of fish meal with defatted Tenebrio molitor meal

Journal of the World Aquaculture Society, Volume 57, Issue 4, August 2026.
Abstract The long‐term suitability of defatted Tenebrio molitor larvae meal (TM) as a substitute for fish meal (FM) protein was evaluated in Chindongo socolofi over a 170‐day feeding period. Six isonitrogenous (38% crude protein) and isoenergetic (4396 kcal kg−1) diets were formulated, in which TM protein replaced FM protein at 0% (control), 20%, 40 ...
Hasan Batuhan Emre Özdoğan
wiley   +1 more source

Synthesis, Molecular Modeling and Assessment of Anticancer Activity of New Potential CYP17A1 Inhibitors. [PDF]

Molecules
Jastrzębski MK, Korga-Plewko A, Iwan M, Kubik J, Stachniuk A, Fornal E, Wróbel TM, Kaczor AA.   +7 more
europepmc   +1 more source