Results 41 to 50 of about 1,927 (159)

A phase IV, open-label three-arm study investigating the impact of a combination of tenofovir disoproxil fumarate/emtricitabine with raltegravir or dolutegravir or elvitegravir/cobicistat on renal function in HIV-1 antiretroviral naïve patients

HIV Research & Clinical Practice, 2021
Objectives: Tenofovir DF (TDF) remains one of the preferred backbone agents for naïve HIV patients starting antiretroviral treatment (ART). The impact of TDF on renal function and metabolic parameters may vary by anchor agent.
Margherita Bracchi, Nicole Pagani, Alessia Dalla Pria, Ana Milinkovic, Nneka Nwokolo, Lervina Thomas, Sundhyia Mandalia, Marta Boffito, Graeme Moyle   +8 more
doaj   +1 more source

Late diagnosis of HIV among Ukrainian refugees in the Czech Republic: A retrospective, observational study

HIV Medicine, EarlyView.
Abstract Objectives This retrospective, observational, non‐interventional study describes the demographics, characteristics, immunological and virological status, coinfections, healthcare unit of HIV diagnosis and follow‐up status of Ukrainian refugees with newly diagnosed HIV in the Czech Republic, with a special focus on those with a late HIV ...
Zofia Bartovská, Ricardo Massmann, David Jilich, Tomáš Groh, Lukáš Fleischhans, Milan Zlámal, Radek Svačinka, David Vydrář, Dalibor Sedláček, Miroslav Kubiska, Jaroslav Kapla, Lucie Nepovímová, Daniela Bartková, Lenka Olbrechtová, Zdeňka Jerhotová, Eva Novotná, Jakub Wnuk, Vratislav Němeček, Pavel Dlouhý, Štěpán Cimrman, Marek Malý   +20 more
wiley   +1 more source

Latest Progress on Tuberculosis and HIV Co‐Infection: A Closer Look at People of Different Ages

Advanced Therapeutics, Volume 8, Issue 4, April 2025.
Tackling the problem of tuberculosis (TB) and human immunodeficiency virus (HIV) co‐infection is a serious global health concern affecting people of all ages. This review presents the characteristics of both diseases, current treatment and diagnostic guidelines, associated problems, innovations in disease management, and overall effects on global ...
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
wiley   +1 more source

Addressing Cardiometabolic Challenges in HIV: Insights, Impact, and Best Practices for Optimal Management—A Narrative Review

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Introduction Since the advent of highly active antiretroviral therapy (HAART), morbidity and mortality rates associated with human immunodeficiency virus (HIV) have significantly decreased leading to prolonged life span of Individuals living with HIV due to the effectiveness of antiretroviral therapy.
Nadine Mugisha, Laura Ghanem, Omar A. I. Komi, Rawan Noureddine, Sanobar Shariff, Magda Wojtara, Mahlagha Mousavi Nanehkeran, Olivier Uwishema   +7 more
wiley   +1 more source

Raltegravir In Vitro Effect on Bilirubin Binding [PDF]

Pediatric Infectious Disease Journal, 2013
Drugs that displace bilirubin from albumin may increase the risk of kernicterus in neonates. We evaluated the effect of raltegravir on bilirubin-albumin binding in pooled neonatal serum using the peroxidase method. Raltegravir had minimal effect on bilirubin-albumin binding at concentrations of 5 and 10 µM, caused a small but statistically significant ...
Larissa Wenning, Mark Mirochnick, David K. Stevenson, Diana F Clarke, Ronald J. Wong   +4 more
openaire   +2 more sources

Physiologically‐based pharmacokinetic modelling of long‐acting injectable cabotegravir and rilpivirine in pregnancy

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 989-1002, April 2025.
Aims Long‐acting cabotegravir and rilpivirine have been approved to manage HIV in adults, but data regarding safe use in pregnancy are limited. Physiologically‐based pharmacokinetic (PBPK) modelling was used to simulate the approved dosing regimens in pregnancy and explore if Ctrough was maintained above cabotegravir and rilpivirine target ...
Shakir Atoyebi, Fazila Bunglawala, Nicolas Cottura, Sandra Grañana‐Castillo, Maiara Camotti Montanha, Adeniyi Olagunju, Marco Siccardi, Catriona Waitt   +7 more
wiley   +1 more source

Extended use of raltegravir in the treatment of HIV-1 infection: optimizing therapy

Infection and Drug Resistance, 2010
Charlotte Charpentier1, Laurence Weiss21Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Laboratoire de Virologie, Université Paris-Diderot, Paris, France; 2Assistance Publique-Hôpitaux de ...
Charlotte Charpentier, Laurence Weiss
doaj  

A programmatic assessment of dolutegravir adverse events and discontinuations in Uganda

HIV Medicine, Volume 26, Issue 4, Page 592-605, April 2025.
Abstract Introduction Dolutegravir is now extensively used in sub‐Saharan Africa as a preferred component of antiretroviral therapy (ART). There is a paucity of large studies using routinely collected data from African people living with HIV on dolutegravir‐based regimens to inform HIV programmes.
Eva Agnes Laker Odongpiny, Melanie Nicol, Elizabeth Katana, Joseph Owori, Allan Buzibye, Kay Sedan, Mike Kesby, Matthew Holden, Noela Owarwo, David Meya, Barbara Castelnuovo, Derek J. Sloan, Christine Sekaggya   +12 more
wiley   +1 more source

HIV/HCV-coinfection: which role can new antiretrovirals such as integrase inhibitors play?

European Journal of Medical Research, 2009
End-stage liver disease has become one of the most frequent causes of death in HIV/HCV-coinfected patients. The role of new antiretrovirals in the progression of liver fibrosis has yet to be defined.
Vogel Martin, Nelson Mark
doaj   +1 more source

Development of HIV Drug‐Resistance Mutations and Antiretroviral Efficacy Among Vietnamese Patients After Failure of 5‐Year First‐Line Therapy

Journal of Clinical Laboratory Analysis, Volume 39, Issue 5, March 2025.
ABSTRACT Background The emergence of drug‐resistant mutations in human immunodeficiency virus (HIV) over time presents a challenge to treatment. We describe the development of drug‐resistance mutations and ART efficacy reduction in Vietnamese patients with failure of first‐line ART during a 5‐year period.
Than Manh Hung, Le Van Nguyen Bang, Le Van Duyet   +2 more
wiley   +1 more source