Results 51 to 60 of about 10,491 (187)

The raltegravir-raltegravir glucuronide (parent-metabolite) compartment model.

, 2016
N1 denotes the first hypothetical transit compartment up to Nn compartment. ktr is the transit rate constant. ka is the absorption rate constant from the hypothetical drug depot compartment to plasma.
Ross Soo (848462), Richie Soong (167983), Ling-Zhi Wang (277888), Soo-Chin Lee (132913), Thomas I. Soh (848458), Lu Fan (155468), Boon C. Goh (848463), Andrea Wong (848459), Pei F. Cheong (848460), Kim-Hor Hee (848457), Nur S. Sapari (848461), Lawrence Soon-U Lee (848455), Kok-Yong Seng (848456), Wei-Peng Yong (114522)   +13 more
core   +1 more source

Treatment durability, satisfaction and quality of life in virologically suppressed HIV‐1 people switching to doravirine: Results from the French study DoraVIH

HIV Medicine, Volume 27, Issue 6, Page 886-895, June 2026.
Abstract Objectives In Europe, most people with HIV‐1(PWH) achieve virologic suppression with effective and well‐tolerated antiretroviral therapies (ART). In this context, patient‐reported outcomes (PRO) are increasingly important for evaluating ART benefits.
Spire Bruno, Robineau Olivier, Pourcher Valérie, Loubet Paul, Palacios Christia, Jacomet Christine, Benachir Haydar, Mariot Philippe, Parienti Jean‐Jacques, Slama Laurence   +9 more
wiley   +1 more source

Raltegravir Pharmacokinetics During Pregnancy

, 2014
OBJECTIVE: We evaluated the pharmacokinetics (PK) of raltegravir in HIV-infected women during pregnancy and postpartum. METHODS: International Maternal Pediatric Adolescent AIDS Clinical Trials 1026s is an ongoing prospective study of antiretroviral PK ...
Watts, DH, Kreitchmann, R, Cressey, TR, Smith, E, Kreitchmann, Regis, Best, Brookie M, Cressey, Tim R, Aweeka, F, Stek, A, Wang, J, Watts, D Heather, Best, BM, Lizak, Patty, Aweeka, Francesca, Capparelli, Edmund V, Stek, Alice, Mirochnick, Mark, Burchett, SK, Burchett, Sandra K, Capparelli, EV, Mirochnick, M, Shapiro, David E, Smith, Elizabeth, Hawkins, Elizabeth, Wang, Jiajia, Shapiro, DE, Lizak, P, Hawkins, E   +27 more
core   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1487-1492, May 2026.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

HIV/HCV-coinfection: which role can new antiretrovirals such as integrase inhibitors play?

European Journal of Medical Research, 2009
End-stage liver disease has become one of the most frequent causes of death in HIV/HCV-coinfected patients. The role of new antiretrovirals in the progression of liver fibrosis has yet to be defined.
Vogel Martin, Nelson Mark
doaj   +1 more source

Effect of Raltegravir on the Total and Unintegrated Proviral HIV Dna during Raltegravir-Based Haart

, 2011
Background Raltegravir is the first approved antiretroviral able to prevent HIV genome integration into the host chromosomes. The aim of the study is to test if raltegravir plasma concentrations can be associated with proviral DNA decline during ...
Alessandra Amendola, Rita Bellagamba, Magdalena Viscione, Giovanni Di Perri, Emanuele Nicastri, Isabella Abbate, Stefano Bonora, Anna L Gallo, Chiara Tommasi, Massimo Tempestilli, Leopoldo Pucillo, Maria R Capobianchi, Gabriella Rozera, Jelena Ivanovic, Pasquale Narciso   +14 more
core   +1 more source

Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Antiretroviral therapy (ART) suppresses HIV replication and protects people living with HIV (PLWH) from progressing to AIDS. However, despite ART, many PLWH experience chronic immune activation, which contributes to premature aging and non‐AIDS‐related comorbidities. One reason for this chronic immune activation (CIA) is HIV and its
Florian Hladik, Sean M. Hughes, Claire N. Levy, Rachel L. Creighton, Romel Mackelprang, Germán G. Gornalusse   +5 more
wiley   +1 more source

Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial

, 2018
BackgroundIn sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART).
Jaika, L, Ennie Chidziva, Kusum Nathoo, Abbas Lugemwa, Mula, S, Matiza, P, Mutsa Bwakura-Dangarembizi (3480167), Tuhirwe, S, James Hakim, Tumsuiime, C, Heyderman, R, Sheila Kabahenda (6041243), Tanui, M, Mwimali, D, Ninsiima, E, James Abach, Kikyonkyo, D, Limbuni, M, Dzabala, N, Ekiru, W, Adong, C, Gibb, DM, Alexander J Szubert, Acen, J, Ocitti, P, Abach, James, Etyang, A, Diana M. Gibb (164420), Nyondo-Mipando, L, Kityo, Cissy, Tusiime, J, Mudenge, B, Ndemera, B, Pett, SL, Anna Griffiths, Sarah L. Pett (283266), Denis, B, Meli, B, Lewa, M Lozi, Spyer, Moira J, Walker, Ann, Njogu, A, Mutsa Bwakura-Dangarembizi, Mwakisha, B, Etyang, T, Acaku, M, Van Oosterhout, J, Kaunda, S, Musoro, Godfrey, Katemba, C, Guti, V, Moyo, C, Mokaya, M, Orido, M Anyango, Diana M Gibb, Sudoi, A, Msuku, H, Heyderman, Robert, Nathoo, Kusum, Baliruno, D, Miles, P, Rashirai, K, Wavamunno, Priscilla, Atwongyeire, D, Ankunda, R, Berkley, J, Gonzalez, C, Agutu, C, Mushahara, F, Shali, A, Phiri, M, Heydermann, R, Abongomera, G, Philliam, A, Mwarumba, S, Gibb, Diana M, Kasozi, M, Nambaziira, F, Abwola, M, Alexander J. Szubert (4591474), Klein, Nigel, Kidega, P, Kusum Nathoo (164465), Kigongo, F, Nemasango, B, Sirikye, S, Abraham Siika (327450), Siika, Abraham, Ayesiga, L, Lugemwa, A, Mwaringa, Shalton, Sarah L Pett, Musiime, A, Lwande, G Omondi, Szubert, AJ, Mutsai, S, Siika, A, Mwalukomo, T, Ndigendawani, M, Musiime, V, Rutto, P, Priscilla Wavamunno (6041261), Immaculate Nkanya (4591471), Moira J Spyer, Spyer, MJ, Simon Wachira (6041246), Wachira, Simon, A. Sarah Walker (145609), Sheha, I, Maitha, S Said, Godfrey Musoro, Griffiths, Anna, Nkanya, Immaculate, Mwebe, S, Ennie Chidziva (164438), Jerotich, H, Apio, F, Kithunga, J, Hakim, James, Nhema, R, Abraham Siika, Cheruiyot, P, Ssennono, F, Mlambo, B, Musodza, Y, Kabaswahili, V, Mallewa, J, Mwanzu, A, Shalton Mwaringa, James Abach (6041258), Baleeta, K, Walker, A Sarah, Pett, S, Mhute, T, Pierre, M, Rweyora, A, Nathoo, K, Kangah, M, Mudzingwa, S, Robert Heyderman, Anna Griffiths (6041240), Chatu Rajapakse (6041252), Priscilla Wavamunno, Mipando, L Nyondo, Mpamize, G, Namisi, R, Cissy Kityo, Aciro, I, Atwine, L, Lugemwa, Abbas, Walker, AS, O'Hare, B, Mboya, C, Nigel Klein (18890), Awuondo, K, Shalton Mwaringa (6041237), Chidziva, Ennie, Abbas Lugemwa (6041234), Linda Nyondo-Mipando (6041264), Njuguna, P, Arach, B, Warambwa, C, Mudogo, A, Noowe, N, Olebo, D, Khadenge, C, Nkomani, S, Maitland, K, Simon Wachira, Szubert, Alexander J, Tinago, GC, Nigel Klein, Timothy Etyang (6041255), Nyondo-Mipanda, L, Nyondo-Mipando, Linda, Mutai, R, Karoney, M, Bwakura-Dangarembizi, Mutsa, Godfrey Musoro (6041249), Natuhurira, T, Shangala, J, Makhaza, L, Nzioka, A, Wale, S, Mwaringa, S, Selemani, G, Immaculate Nkanya, Bwanali, J, Nkanya, I, A Sarah Walker, Kalama, C, Cherutich, S, Nyandiko, W, Wachira, S, Spyer, M, Latham, H, Linda Nyondo-Mipando, Chirwa, E, Fondo, A, Szubert, A, Rajapakse, C, Manda, Y, Mwambingu, G, Otto, B, Kemigisa, M, Musoro, G, Nambi, E, Shikuku, J, Banda, P, Kyomuhangi, J, Hakim, J, Njenga, K, Amone, G, Amone, A, Kutto, I, Etyang, Timothy, James Hakim (164478), Robert Heyderman (3401696), Timothy Etyang, Kityo, C, Chitongo, S, Willard, M, Omongin, J, Cissy Kityo (168842), Bwakura-Dangarembizi, M, Sheila Kabahenda, Mbonye, A, Tukwasibwe, D, Chatu Rajapakse, Wools-Kaloustian, K, Reid, A, Wavamunno, P, Choge, J, Masesa, C, Pett, Sarah L, Gibb, D, Nicholas, S, Vhembo, S, Griffiths, A, Chidziva, E, Berejena, C, Senkindu, T, Bhiri, J, Ziwoya, M, Moira J. Spyer (4591462), Mvula, L, Abach, J, Rajapakse, Chatu, Kabahenda, Sheila, Nankya, A, Steamer, J, Injera, W, Kelly, C, REALITY trial team, Kabahenda, S, Mukuye, A, Okweny, D, Mengich, C, Mugyenyi, P, Klein, N, Ocung, E   +260 more
core   +1 more source

Considerations for the Use of AAV‐based Gene Therapy in HIV‐Positive Individuals With Haemophilia

Haemophilia, Volume 32, Issue 3, Page 584-592, May/June 2026.
ABSTRACT Introduction There is a high prevalence of human immunodeficiency virus (HIV) infection among the haemophilia community due to treatment in the 1970s and 1980s with contaminated clotting factor. Lifelong treatment regimens for haemophilia and HIV are burdensome alone and pose a particular challenge for individuals living with both conditions ...
Jürgen K. Rockstroh, Julia C. Stingl, Marco Stadler, Anja Reichert, Heiner Wedemeyer, Johannes Oldenburg   +5 more
wiley   +1 more source

Modern antiretroviral regimens

Медицинский совет, 2016
The article presents the results of major international studies (STARTMRK, ACTG A5257, SPRING 2, the SINGLE and FLAMINGO), which convincingly demonstrated the effectiveness and safety of drugs from the group of integrase inhibitors (raltegravir and ...
A. V. Kravchenko
doaj   +1 more source