Results 41 to 50 of about 14,372 (211)
Journal of Pharmaceutical Analysis, 2015 A selective and rapid high-performance liquid chromatographyâtandem mass spectrometry method was developed and validated for the quantification of raltegravir using raltegravir-d3 as an internal standard (IS).
Ajay Gupta +5 more
doaj +1 more source
Antimicrobial Resistance and Infection Control, 2020 Sub-Saharan African countries are transitioning to dolutegravir-based regimens, even for patients with extensive previous drug exposure, including first-generation integrase strand-transfer inhibitors (INSTI) such as raltegravir. Such exposure might have
J. Fokam +23 more
semanticscholar +1 more source
Restoring Meropenem Activity Against VIM-1-Producing Klebsiella pneumoniae Through Zinc-Binding Ligands. [PDF]
ChembiochemApproved zinc‐binding drugs and newly synthesized HisPyr ligands were evaluated as adjuvants to meropenem against metallo‐β‐lactamase‐producing Klebsiella pneumoniae. Chlorpropamide and D‐penicillamine restored meropenem activity against the VIM‐1‐producing strain, while computational analyses supported interactions with the enzyme's binuclear zinc ...
Ragusa C +6 more
europepmc +2 more sources
PLoS ONE, 2016 BackgroundIrinotecan toxicity correlates with UGT1A1 activity. We explored whether phenotyping UGT1A1 using a probe approach works better than current genotyping methods.MethodsTwenty-four Asian cancer patients received irinotecan as part of the FOLFIRI ...
Lawrence Soon-U Lee +13 more
doaj +1 more source
The Lancet HIV, 2020 Summary Background While antiretroviral regimens containing integrase inhibitors rapidly suppress HIV viral load in non-pregnant adults, few published randomized trial data have compared the safety and efficacy of any integrase inhibitor to efavirenz ...
E. João +27 more
semanticscholar +1 more source
Raltegravir: penghambat enzim integrase HIV-1 [PDF]
, 2014 Raltegravir efektif digunakan sebagai bagian dari kombinasi ART baik untuk pasien treatment-naive maupun pasien treatmentexperienced; aturan pemberian raltegravir dua kali per hari (BID). Harga raltegravir lebih mahal daripada harga jenis ART lain.
Herawati, Fauna
core +2 more sources
HIV Research & Clinical Practice, 2021 Objectives: Tenofovir DF (TDF) remains one of the preferred backbone agents for naïve HIV patients starting antiretroviral treatment (ART). The impact of TDF on renal function and metabolic parameters may vary by anchor agent.
Margherita Bracchi +8 more
doaj +1 more source
Direct Regioselective para‐Fluorination via I(I)/I(III) Catalysis
Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.A direct, para‐selective fluorination by I(I)/I(III) catalysis is disclosed that does not require substrate pre‐functionalization. This strategy leverages the Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para‐selective sequence. The C3‐side chain maps onto a range of common drug scaffolds and allows the
Christoph Roblick +5 more
wiley +2 more sources
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionSecond-generation integrase strand transfer inhibitors (INSTIs) are preferred treatment options worldwide, and dolutegravir (DTG) is the treatment of choice in resource-limited settings.
José Ramón Santos +64 more
doaj +1 more source
HIV resistance to raltegravir [PDF]
, 2009 Similar to all antiretroviral drugs, failure of raltegravirbased treatment regimens to fully supress HIV replication almost invariably results in emergence of HIV resistance to this new drug.
Clavel, François, Clavel François
core +2 more sources