Results 111 to 120 of about 48,769 (198)
Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeutic applications, this study investigates M4 receptor ...
Madeleine Merz +5 more
wiley +1 more source
Influence of cargo size on Ran and energy requirements for nuclear protein import [PDF]
Previous work has shown that the transport of some small protein cargoes through the nuclear pore complex (NPC) can occur in vitro in the absence of nucleoside triphosphate hydrolysis.
Bednenko, Janna +4 more
core +2 more sources
Multi‐Omic Analysis of Glutamate Excitotoxicity in Primary Neuronal Cultures
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.Our study on rat neuron cells found 250 μM glutamate to be toxic, causing neuron death. We identified genes in pathways linked to apoptosis, neuron plasticity, and cell signaling, along with proteins regulating the cell cycle and tumor proliferation.
Jennifer H. Nguyen +13 more
wiley +1 more source
Adiponectin and gastric fundus: A potential target for gut–brain axis dysfunctions
Physiological Reports, Volume 13, Issue 11, June 2025.Abstract Adiponectin (ADPN) is a pleiotropic hormone produced by adipose tissue involved in the control of body weight, energy expenditure, and feeding behaviors. Alongside a central effect, ADPN acts on peripheral organs such as the stomach, where it can favor gastric fundus relaxation, reinforcing central satiety signals.
R. Garella +7 more
wiley +1 more source
The FASEB Journal, Volume 39, Issue 10, 31 May 2025.Inhibition of focal adhesion kinase autophosphorylation (Y397) in adipocytes is associated with reduced glucose uptake, likely via the disruptions of Arp2/3 and Rac1 activity, leading to impaired cytoskeletal remodeling and consequential impairment of GLUT4 translocation. B = binding, GTP = GTP‐loading, P = phosphorylation.
Franziska Kopietz +4 more
wiley +1 more source
PDBrestore: A Free Web Interface for Processing and Fixing Protein Chains From Raw PDB Files
Journal of Computational Chemistry, Volume 46, Issue 13, May 15, 2025.PDBrestore is a freely accessible web interface to repair raw PDB files fetched from the Protein Data Bank for molecular dynamics applications. The interface, with minimal end‐user intervention, repairs common PDB defects such as missing atoms, incomplete side chains, missing residues, non‐standard residue names or non‐standard atom labels, manages the
Piero Procacci
wiley +1 more source
Chemistry – A European Journal, Volume 31, Issue 27, May 14, 2025.Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Naomi Horiuchi +8 more
wiley +1 more source
RAB family gene expression in breast cancer cells under influence of paclitaxel [PDF]
, 2011 The aim of this study was to investigate the role of paclitaxel on RAB family of genes in primary breast cancer cell lines. The cancer breast cells obtained from 40 women during mastectomy were used to address this issue. The group included patients with
Andrzej Wilkolaski +3 more
core +1 more source
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors
Oncogene, 2004 P. Vargiu +6 more
semanticscholar +1 more source