Results 61 to 70 of about 2,908,473 (291)

Random motion of a circle microswimmer in a random environment

New Journal of Physics, 2020
We simulate the dynamics of a single circle microswimmer exploring a disordered array of fixed obstacles. The interplay of two different types of randomness, quenched disorder and stochastic noise, is investigated to unravel their impact on the transport
Oleksandr Chepizhko, Thomas Franosch
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Quenched invariance principle for random walks in balanced random environment

, 2011
We consider random walks in a balanced random environment in $\mathbb{Z}^d$, $d\geq 2$. We first prove an invariance principle (for $d\ge2$) and the transience of the random walks when $d\ge 3$ (recurrence when $d=2$) in an ergodic environment which is ...
A. De Masi, G. Ben Arous, G. Grimmett, G. Papanicolaou, G.F. Lawler, H.J. Kuo, H.J. Kuo, H.O. Georgii, J.P. Bouchaud, M. Barlow, M. Barlow, M. Fekete, N. Berger, O. Zeitouni, Ofer Zeitouni, P. Mathieu, P. Mathieu, P. Mathieu, U. Krengel, V. Sidoravicius, Xiaoqin Guo   +20 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Symmetric random walks in random environments [PDF]

Communications in Mathematical Physics, 1982
We consider a random walk on thed-dimensional lattice ℤ d where the transition probabilitiesp(x,y) are symmetric,p(x,y)=p(y,x), different from zero only ify−x belongs to a finite symmetric set including the origin and are random.
Anshelevich, V. V., Khanin, K. M., Sina\u{\i}, Ya. G.   +2 more
openaire   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Performance Modeling of Cloud Systems by an Infinite-Server Queue Operating in Rarely Changing Random Environment

Future Internet
This paper considers a heterogeneous queuing system with an unlimited number of servers, where the parameters are determined by a random environment. A distinctive feature is that the parameters of the exponential distribution of the request processing ...
Svetlana Moiseeva, Evgeny Polin, Alexander Moiseev, Janos Sztrik   +3 more
doaj   +1 more source

Random Environment Integer-Valued Autoregressive Process with Discrete Laplace Marginal Distributions

Revstat Statistical Journal, 2023
A new random environment integer-valued autoregressive process of order 1 with discrete Laplace marginal distributions and with r states (abbrev. RrDLINAR1(M, A)) is introduced.
Bogdan A. Pirković , Miroslav M. Ristić, Aleksandar S. Nastić   +2 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Algorithmic Analysis of Queuing System with Varying Number of Servers, Phase-Type Service Time Distribution, and Changeable Arrival Process Depending on Random Environment

Computation
An MAP/PH/N-type queuing system functioning within a finite-state Markovian random environment is studied. The random environment’s state impacts the number of available servers, the underlying processes of customer arrivals and service, and the ...
Alexander Dudin, Olga Dudina, Sergei Dudin   +2 more
doaj   +1 more source