Results 131 to 140 of about 16,565,874 (393)

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Random Responses of Shield Tunnel to New Tunnel Undercrossing Considering Spatial Variability of Soil Elastic Modulus

Applied Sciences
This paper investigates the effect of spatial variability of soil elastic modulus on the longitudinal responses of the existing shield tunnel to the new tunnel undercrossing using a random two-stage analysis method (RTSAM).
Xiaolu Gan, Nianwu Liu, Adam Bezuijen, Xiaonan Gong   +3 more
doaj   +1 more source

Jeffreys Divergence and Generalized Fisher Information Measures on Fokker-Planck Space-Time Random Field. [PDF]

Entropy (Basel), 2023
Zhang J.
europepmc   +1 more source

Cauchy Markov Random Field Priors for Bayesian Inversion [PDF]

, 2021
Neil K. Chada, Lassi Roininen, Jarkko Suuronen   +2 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Efficient and conservative estimation reliability analysis of strip footing on spatially variable c - ϕ soil using random finite element limit analysis

Studia Geotechnica et Mechanica
The study deals with reliability analysis of strip foundation on spatially variable c - ϕ soil. The spatial variability of soil strength parameters, namely cohesion c and friction angle ϕ is modelled using anisotropic uncorrelated random fields ...
Szabowicz Hubert, Kawa Marek, Puła Wojciech   +2 more
doaj   +1 more source

Stochastic Extension of Nonlocal Macro–Mesoscale Consistent Damage Model for Fracture Behaviors of Concrete Materials

Buildings
The nonlinearity and randomness in composite materials such as concrete present challenges regarding the safety analysis and reliability-based design of structures.
Guangda Lu, Jiankang Xie
doaj   +1 more source

Randomized Distributed Configuration Management of Wireless Networks: Multi-layer Markov Random Fields and Near-Optimality [PDF]

, 2008
Chunayi Ji, Sung-eok Jeon
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Hidden Markov random field models for cell-type assignment of spatially resolved transcriptomics. [PDF]

Bioinformatics, 2023
Zhong C, Tian T, Wei Z.
europepmc   +1 more source