Results 71 to 80 of about 1,877,864 (293)
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Transverse confinement of waves in 3D random media
, 2010 We study the transmission of a tightly focused beam through a thick slab of 3D disordered medium in the Anderson localized regime. We show that the transverse profile of the transmitted beam exhibits clear signatures of Anderson localization and that its
B. A. van Tiggelen +5 more
core +3 more sources
Excess noise for coherent radiation propagating through amplifying random media [PDF]
, 1999 A general theory is presented for the photodetection statistics of coherent radiation that has been amplified by a disordered medium. The beating of the coherent radiation with the spontaneous emission increases the noise above the shot-noise level.
Beenakker, C. W. J., Patra, M.
core +4 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Anomalous Fluctuations of Directed Polymers in Random Media
, 1993 A systematic analysis of large scale fluctuations in the low temperature pinned phase of a directed polymer in a random potential is described. These fluctuations come from rare regions with nearly degenerate ``ground states''.
A. J. McKane +46 more
core +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The average transmitted wave in random particulate materials
New Journal of PhysicsMicrowave remote sensing is significantly altered when passing through clouds or dense ice. This phenomenon is not unique to microwaves; for instance, ultrasound is also disrupted when traversing through heterogeneous tissues.
Aristeidis Karnezis +2 more
doaj +1 more source
Homogenization in elastic random media
Computer Assisted Methods in Engineering and Science, 2023 The theoretical foundation and a numerical procedure of deriving stochastic effective properties of linear-elastic periodic fibre composite are presented.
Marcin Kamiński
doaj